Skip to content
2000
Volume 20, Issue 4
  • ISSN: 1574-8855
  • E-ISSN: 2212-3903

Abstract

Mechanistic investigations in both animal models and human subjects have consistently elucidated a causal relationship between obesity, diabetes, and Alzheimer's disease (AD). Alzheimer's disease is the predominant etiology of dementia, marked by progressive cerebral degeneration characterized by the formation of intracellular neurofibrillary tangles and extracellular amyloid beta (Aβ) plaques. Adipose tissue secretes bioactive signaling molecules known as adipokines. Interactions between adipose tissue and the central nervous system serve as the foundational mechanism contributing to the elevated susceptibility of individuals with obesity to the onset of neurologic disorders, including cognitive and mood-related disturbances. Omentin is a recently discovered adipokine that has gained attention for study because of its pleiotropic effects on several disorders. The specific receptor responsible for binding with Omentin remains unidentified thus far. This investigation elucidates the variability in Omentin levels observed in multiple pathological conditions. Therapeutic methods to raise omentin-1 levels may be helpful for the treatment or prevention of several illnesses. Increases in circulating omentin-1 levels can be achieved with weight loss, an olive oil-rich diet, aerobic exercise, atorvastatin therapy, and the use of diabetes medications. It is also possible to use circulating omentin-1 as a biomarker of obesity, diabetes, metabolic syndrome, atherosclerosis, ischemic heart disease, inflammatory disease, cancer, and neurological diseases AMP-activated protein kinase/Akt/nuclear factor-κB/mitogen-activated protein kinase (ERK, JNK, and p38) signaling. This review provides insights into the potential use of omentin-1 as a biomarker for Obesity, Diabetes, and associated metabolic and neurological disorders.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cdth/10.2174/0115748855296758240408040336
2024-04-16
2025-10-03

  • From This Site

    /content/journals/cdth/10.2174/0115748855296758240408040336
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Sosa-OrtizA.L. Acosta-CastilloI. PrinceM.J. Epidemiology of dementias and Alzheimer’s disease.Arch. Med. Res.201243860060810.1016/j.arcmed.2012.11.003 23159715
     [Google Scholar]
  2. KimJ.Y. BaruaS. JeongY.J. LeeJ.E. Adiponectin: The potential regulator and therapeutic target of obesity and Alzheimer’s disease.Int. J. Mol. Sci.20202117641910.3390/ijms21176419 32899357
     [Google Scholar]
  3. AlsubaieN. Al-kuraishyH.M. Al-GareebA.I. Statins use in Alzheimer disease: Bane or boon from frantic search and narrative review.Brain Sci.20221210129010.3390/brainsci12101290 36291224
     [Google Scholar]
  4. WaragaiM. HoG. TakamatsuY. Importance of adiponectin activity in the pathogenesis of Alzheimer’s disease.Ann. Clin. Transl. Neurol.20174859160010.1002/acn3.436 28812049
     [Google Scholar]
  5. KimM.W. AbidN. JoM.H. JoM.G. YoonG.H. KimM.O. Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer’s disease-like pathologies.Sci. Rep.2017711243510.1038/s41598‑017‑12632‑9 28963462
     [Google Scholar]
  6. LaneC.A. HardyJ. SchottJ.M. Alzheimer’s disease.Eur. J. Neurol.2018251597010.1111/ene.13439 28872215
     [Google Scholar]
  7. WanZ. LittleJ.P. Adiponectin and Alzheimer’s disease: Is there a link.Inflamm. Cell Signal.20141
     [Google Scholar]
  8. NgR. ChanK.H. Potential neuroprotective effects of adiponectin in Alzheimer’s disease.Int. J. Mol. Sci.201718359210.3390/ijms18030592 28282917
     [Google Scholar]
  9. AbdullatifY.M.R. AhmedK.Y. El-SenosyF.M. Mohammed Abd El-AzizR.E-S. Serum omentin-1 levels in type II diabetes and its relationship with obesity.Sci. J. Al-Azhar Med. Fac. Girls20226171310.4103/sjamf.sjamf_227_21
     [Google Scholar]
  10. FantuzziG. Adipose tissue, adipokines, and inflammation.J. Allergy Clin. Immunol.2005115591191910.1016/j.jaci.2005.02.023 15867843
     [Google Scholar]
  11. LeeT.H. ChengK.K. HooR.L. SiuP.M. YauS. The novel perspectives of adipokines on brain health.Int. J. Mol. Sci.20192022563810.3390/ijms20225638 31718027
     [Google Scholar]
  12. DecP. Poniewierska-BaranA. ModrzejewskiA. PawlikA. The Role of Omentin-1 in Cancers Development and Progression.Cancers (Basel)20231515379710.3390/cancers15153797 37568613
     [Google Scholar]
  13. SaremiA. AsghariM. GhorbaniA. Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men.J. Sports Sci.201028999399810.1080/02640414.2010.484070 20544489
     [Google Scholar]
  14. ChyraM. RoczniakW. ŚwiętochowskaE. DudzińskaM. OświęcimskaJ. The Effect of the ketogenic diet on adiponectin, omentin and vaspin in children with drug-resistant epilepsy.Nutrients202214347910.3390/nu14030479 35276837
     [Google Scholar]
  15. EscotéX. Gómez-ZoritaS. López-YoldiM. Role of omentin, vaspin, cardiotrophin-1, TWEAK and NOV/CCN3 in obesity and diabetes development.Int. J. Mol. Sci.2017188177010.3390/ijms18081770 28809783
     [Google Scholar]
  16. AugerC. KajimuraS. Adipose tissue remodeling in pathophysiology.Annu. Rev. Pathol.2023181719310.1146/annurev‑pathol‑042220‑023633 36070562
     [Google Scholar]
  17. MancusoP. The role of adipokines in chronic inflammation.ImmunoTargets Ther.20165475610.2147/ITT.S73223 27529061
     [Google Scholar]
  18. MohajanD. MohajanH.K. Obesity and Its Related Diseases: A New Escalating Alarming in Global Health.J Innovations Med Res202323122310.56397/JIMR/2023.03.04
     [Google Scholar]
  19. KiliaanA.J. ArnoldussenI.A.C. GustafsonD.R. Adipokines: a link between obesity and dementia?Lancet Neurol.201413991392310.1016/S1474‑4422(14)70085‑7 25142458
     [Google Scholar]
  20. DewalR.S. WolfrumC. Master of disguise: deconvoluting adipose tissue heterogeneity and its impact on metabolic health.Curr. Opin. Genet. Dev.20238110208510.1016/j.gde.2023.102085 37421902
     [Google Scholar]
  21. Forny-GermanoL. De FeliceF.G. VieiraM.N.N. The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer’s disease.Front. Neurosci.201912102710.3389/fnins.2018.01027 30692905
     [Google Scholar]
  22. LauW.B. OhashiK. WangY. Role of adipokines in cardiovascular disease.Circ. J.201781792092810.1253/circj.CJ‑17‑0458 28603178
     [Google Scholar]
  23. OuchiN. ParkerJ.L. LugusJ.J. WalshK. Adipokines in inflammation and metabolic disease.Nat. Rev. Immunol.2011112859710.1038/nri2921 21252989
     [Google Scholar]
  24. Clemente-SuárezV.J. Redondo-FlórezL. Beltrán-VelascoA.I. The role of adipokines in health and disease.Biomedicines2023115129010.3390/biomedicines11051290 37238961
     [Google Scholar]
  25. ZhouY. ZhangB. HaoC. Omentin-A novel adipokine in respiratory diseases.Int. J. Mol. Sci.20171917310.3390/ijms19010073 29283409
     [Google Scholar]
  26. WatanabeT. Watanabe-KominatoK. TakahashiY. KojimaM. WatanabeR. Adipose tissue‐derived omentin‐1 function and regulation.Compr. Physiol.20177376578110.1002/cphy.c160043 28640441
     [Google Scholar]
  27. LesnáJ. TicháA. HyšplerR. Omentin-1 plasma levels and cholesterol metabolism in obese patients with diabetes mellitus type 1: impact of weight reduction.Nutr. Diabetes2015511e183e310.1038/nutd.2015.33 26524638
     [Google Scholar]
  28. CaiM. ZhaoD. HanX. The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease.Front. Immunol.202314127105110.3389/fimmu.2023.1271051 37822930
     [Google Scholar]
  29. RichardA.J. Adipose tissue: physiology to metabolic dysfunction.Endotext2020[internet]
     [Google Scholar]
  30. ZengiS. ZengiO. KirankayaA. KucukS.H. KutanisE.E. YigitO. Serum omentin-1 levels in obese children.J. Pediatr. Endocrinol. Metab.201932324725110.1515/jpem‑2018‑0231 30817300
     [Google Scholar]
  31. ÇelikM. NarR. NarG. SökmenE. GünverG. Serum omentin-1 levels in hypertensive patients.J. Hum. Hypertens.202135329029510.1038/s41371‑020‑00420‑4 32978495
     [Google Scholar]
  32. CastroC.A. SilvaK.A. RochaM.C. Exercise and omentin: their role in the crosstalk between muscle and adipose tissues in type 2 diabetes mellitus rat models.Front. Physiol.20199188110.3389/fphys.2018.01881 30666216
     [Google Scholar]
  33. SplichalZ. Bienertova-VaskuJ. NovakJ. The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population.Nutr. Neurosci.2015181414810.1179/1476830513Y.0000000100 24552613
     [Google Scholar]
  34. LinX. SunY. YangS. Omentin-1 modulates macrophage function via integrin receptors αvβ3 and αvβ5 and reverses plaque vulnerability in animal models of atherosclerosis.Front. Cardiovasc. Med.2021875792610.3389/fcvm.2021.757926 34796216
     [Google Scholar]
  35. YangR.Z. LeeM.J. HuH. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.Am. J. Physiol. Endocrinol. Metab.20062906E1253E126110.1152/ajpendo.00572.2004 16531507
     [Google Scholar]
  36. SenthilkumarG.P. AnithalekshmiM.S. YasirM. ParameswaranS. PackirisamyR. BobbyZ. Role of omentin 1 and IL-6 in type 2 diabetes mellitus patients with diabetic nephropathy.Diabetes Metab. Syndr.2018121232610.1016/j.dsx.2017.08.005 28864059
     [Google Scholar]
  37. ElsaidN.H. SadikN.A. AhmedN.R. FayezS.E. MohammedN.A.E.G. Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters.J. Clin. Transl. Endocrinol.201813141910.1016/j.jcte.2018.05.003 30023310
     [Google Scholar]
  38. TanY.L. ZhengX.L. TangC.K. The protective functions of omentin in cardiovascular diseases.Clin. Chim. Acta20154489810610.1016/j.cca.2015.05.019 26079253
     [Google Scholar]
  39. NagataS. NishiyamaS. IkazakiY. Bacterial lipopolysaccharides stimulate production of XCL1, a calcium-dependent lipopolysaccharide-binding serum lectin, in Xenopus laevis.Dev. Comp. Immunol.20134029410210.1016/j.dci.2013.02.008 23454582
     [Google Scholar]
  40. HusseinA.A. AhmedN.A. SakrH.I. AtiaT. AhmedO.M. Omentin roles in physiology and pathophysiology: an up-to-date comprehensive review.Arch. Physiol. Biochem.202311410.1080/13813455.2023.2283685 37994431
     [Google Scholar]
  41. RespektaN. PichK. MlyczyńskaE. Plasma level of omentin-1, its expression, and its regulation by gonadotropin-releasing hormone and gonadotropins in porcine anterior pituitary cells.Sci. Rep.20231311932510.1038/s41598‑023‑46742‑4 37935840
     [Google Scholar]
  42. VasamsettiS.B. NatarajanN. SadafS. FlorentinJ. DuttaP. Regulation of cardiovascular health and disease by visceral adipose tissue‐derived metabolic hormones.J. Physiol.2023601112099212010.1113/JP282728 35661362
     [Google Scholar]
  43. TanB.K. AdyaR. FarhatullahS. ChenJ. LehnertH. RandevaH.S. Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome.Diabetes201059123023303110.2337/db10‑0124 20852028
     [Google Scholar]
  44. GuruS.R. AghanashiniS. Estimation and correlation of salivary and serum omentin-1 in chronic periodontitis: an interventional study.J. Dent. Sci.2023152vi10.26463/rjds.15_2_10
     [Google Scholar]
  45. Nosrati-OskouieM. AsghariG. YuzbashianE. Does dietary intake impact omentin gene expression and plasma concentration? A systematic review.Lifestyle Genomics2021142496110.1159/000513885 33626523
     [Google Scholar]
  46. DopytalskaK. KaliszM. LitwiniukA. WaleckaI. BikW. Baranowska-BikA. In the pursuit of metabolic markers of systemic sclerosis—plasma adiponectin and omentin-1 in monitoring the course of the disease.Int. J. Mol. Sci.20232412998810.3390/ijms24129988 37373131
     [Google Scholar]
  47. KhoramipourK. ChamariK. HekmatikarA.A. Adiponectin: Structure, physiological functions, role in diseases, and effects of nutrition.Nutrients2021134118010.3390/nu13041180 33918360
     [Google Scholar]
  48. MohitJ AriG MahendraJ Determination of serum and gingival crevicular fluid levels of omentin in healthy and rheumatoid arthritis subjects with and without periodontitis.Oral Dis2023odi.1469510.1111/odi.14695 37498907
     [Google Scholar]
  49. RizzoM.R. FasanoR. PaolissoG. Adiponectin and cognitive decline.Int. J. Mol. Sci.2020216201010.3390/ijms21062010 32188008
     [Google Scholar]
  50. SperlingM. GrzelakT. PelczyńskaM. BogdańskiP. FormanowiczD. CzyżewskaK. Association of Serum Omentin-1 Concentration with the Content of Adipose Tissue and Glucose Tolerance in Subjects with Central Obesity.Biomedicines202311233110.3390/biomedicines11020331 36830868
     [Google Scholar]
  51. WangY. SunM. WangZ. LiX. ZhuY. LiY. Omentin-1 ameliorates the attachment of the leukocyte THP-1 cells to HUVECs by targeting the transcriptional factor KLF2.Biochem. Biophys. Res. Commun.2018498115215610.1016/j.bbrc.2018.02.012 29408455
     [Google Scholar]
  52. AvilaC. HollowayA.C. HahnM.K. An overview of links between obesity and mental health.Curr. Obes. Rep.20154330331010.1007/s13679‑015‑0164‑9 26627487
     [Google Scholar]
  53. OkamuraY. AdachiK. NiijimaR. Human omentin-1 reduces vascular insulin resistance and hypertension in Otsuka Long-Evans Tokushima Fatty rats.Naunyn Schmiedebergs Arch. Pharmacol.20231910.1007/s00210‑023‑02795‑w 37955693
     [Google Scholar]
  54. LetraL. RodriguesT. MatafomeP. SantanaI. SeiçaR. Adiponectin and sporadic Alzheimer’s disease: Clinical and molecular links.Front. Neuroendocrinol.20195211110.1016/j.yfrne.2017.10.002 29038028
     [Google Scholar]
  55. ZhouH. ZhangZ. QianG. ZhouJ. Omentin‐1 attenuates adipose tissue inflammation via restoration of TXNIP/NLRP3 signaling in high‐fat diet‐induced obese mice.Fundam. Clin. Pharmacol.202034672173510.1111/fcp.12575 32479684
     [Google Scholar]
  56. Moreno-NavarreteJ.M. OrtegaF. CastroA. SabaterM. RicartW. Fernández-RealJ.M. Circulating omentin as a novel biomarker of endothelial dysfunction.Obesity (Silver Spring)20111981552155910.1038/oby.2010.351 21293447
     [Google Scholar]
  57. RothermelJ. LassN. BarthA. ReinehrT. Link between omentin‐1, obesity and insulin resistance in children: Findings from a longitudinal intervention study.Pediatr. Obes.2020155e1260510.1111/ijpo.12605 31840425
     [Google Scholar]
  58. NgR.C.L. ChengO.Y. JianM. Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice.Mol. Neurodegener.20161117110.1186/s13024‑016‑0136‑x 27884163
     [Google Scholar]
  59. NishimuraM. MoriokaT. HayashiM. Plasma omentin levels are inversely associated with atherosclerosis in type 2 diabetes patients with increased plasma adiponectin levels: a cross-sectional study.Cardiovasc. Diabetol.201918116710.1186/s12933‑019‑0973‑3 31805941
     [Google Scholar]
  60. LeeH.J. SeoH.I. ChaH.Y. YangY.J. KwonS.H. YangS.J. Diabetes and Alzheimer’s disease: mechanisms and nutritional aspects.Clin. Nutr. Res.20187422924010.7762/cnr.2018.7.4.229 30406052
     [Google Scholar]
  61. TanB.K. PuaS. SyedF. LewandowskiK.C. O’HareJ.P. RandevaH.S. Decreased plasma omentin‐1 levels in Type 1 diabetes mellitus.Diabet. Med.200825101254125510.1111/j.1464‑5491.2008.02568.x 19046210
     [Google Scholar]
  62. RaoS.S. HuY. XieP.L. Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines.Bone Res.201861910.1038/s41413‑018‑0012‑0 29619269
     [Google Scholar]
  63. KhoshiA. BajestaniM.K. ShakeriH. GoodarziG. AziziF. Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes.Lipids Health Dis.201918114210.1186/s12944‑019‑1085‑5 31200723
     [Google Scholar]
  64. PanX. KamingaA.C. WenS.W. AcheampongK. LiuA. Omentin-1 in diabetes mellitus: A systematic review and meta-analysis.PLoS One20191412e022629210.1371/journal.pone.0226292 31821362
     [Google Scholar]
  65. Al-GareebA. AlrubaiH. SuliamanS. Effects of gliclazide add on metformin on serum omentin-1 levels in patients with type 2 diabetes mellitus.Indian J. Endocrinol. Metab.201620219519810.4103/2230‑8210.176355 27042415
     [Google Scholar]
  66. YasirM. SenthilkumarG.P. JayashreeK. RameshB.K. VadivelanM. PalanivelC. Association of serum omentin-1, apelin and chemerin concentrations with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus patients.Arch. Physiol. Biochem.2022128231332010.1080/13813455.2019.1680698 31686535
     [Google Scholar]
  67. LeandroA. QueirozM. AzulL. SeiçaR. SenaC.M. Omentin: A novel therapeutic approach for the treatment of endothelial dysfunction in type 2 diabetes.Free Radic. Biol. Med.202116223324210.1016/j.freeradbiomed.2020.10.021 33099000
     [Google Scholar]
  68. ZhangD-m Adiponectin, omentin, ghrelin, and visfatin levels in obese patients with severe obstructive sleep apnea.BioMed Res Int2018201810.1155/2018/3410135
     [Google Scholar]
  69. SenaC.M. Omentin: A key player in glucose homeostasis, atheroprotection, and anti-inflammatory potential for cardiovascular health in obesity and diabetes.Biomedicines202412228410.3390/biomedicines12020284 38397886
     [Google Scholar]
  70. ErolM. KaranF. OzelA. Bostan GayretO. ZengiO. Serum Omentin-1 Levels in Obese Adolescents with Vitamin D Deficiency: A Prospective Cross-sectional Study.Iran. J. Pediatr.202333510.5812/ijp‑137958
     [Google Scholar]
  71. Zabetian-TarghiF. MirzaeiK. KeshavarzS.A. Hossein-NezhadA. Modulatory role of omentin-1 in inflammation: cytokines and dietary intake.J. Am. Coll. Nutr.201635867067810.1080/07315724.2015.1126207 27331575
     [Google Scholar]
  72. JiL. ZhangL. LiangZ. Role of omentin-1 in susceptibility to anxiety and depression like behaviors.Mol. Cell. Endocrinol.202357411199010.1016/j.mce.2023.111990 37321286
     [Google Scholar]
  73. KoC.Y. LinY.Y. AchudhanD. Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization.Int. J. Biol. Sci.202319165275528910.7150/ijbs.86701 37928270
     [Google Scholar]
  74. SenaC.M. Omentin: An atheroprotective adipokine for vascular health.Biomedicines20231228410.20944/preprints202311.1733.v1
     [Google Scholar]
  75. AliasghariF. IzadiA. JabbariM. Are vaspin and omentin-1 related to insulin resistance, blood pressure and inflammation in NAFLD patients?J. Med. Biochem.201837447047510.2478/jomb‑2018‑0006 30584407
     [Google Scholar]
  76. AntariA.D. The effect of x-ray radiation to il-10 levels in secretome mesenchymal stem cells cosmeceutical product.International J Cel BiomedSci202324118125
     [Google Scholar]
  77. EderP. AdlerM. DobrowolskaA. Kamhieh-MilzJ. WitowskiJ. The role of adipose tissue in the pathogenesis and therapeutic outcomes of inflammatory bowel disease.Cells20198662810.3390/cells8060628 31234447
     [Google Scholar]
  78. KarampelaI. VallianouN.G. TsilingirisD. Diagnostic and prognostic value of serum omentin-1 in Sepsis: A prospective study in critically ill patients.Medicina202359583310.3390/medicina59050833 37241065
     [Google Scholar]
  79. KazamaK. UsuiT. OkadaM. HaraY. YamawakiH. Omentin plays an anti-inflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth muscle cells.Eur. J. Pharmacol.20126861-311612310.1016/j.ejphar.2012.04.033 22554771
     [Google Scholar]
  80. LinS. LiX. ZhangJ. ZhangY. Omentin-1: Protective impact on ischemic stroke via ameliorating atherosclerosis.Clin. Chim. Acta2021517314010.1016/j.cca.2021.02.004 33607071
     [Google Scholar]
  81. HuangN.Q. JinH. ZhouS. ShiJ. JinF. TLR4 is a link between diabetes and Alzheimer’s disease.Behav. Brain Res.201731623424410.1016/j.bbr.2016.08.047 27591966
     [Google Scholar]
  82. WalterS. LetiembreM. LiuY. Role of the toll-like receptor 4 in neuroinflammation in Alzheimer’s disease.Cell. Physiol. Biochem.200720694795610.1159/000110455 17982277
     [Google Scholar]
  83. MiklossyJ. McGeerP.L. Common mechanisms involved in Alzheimer’s disease and type 2 diabetes: A key role of chronic bacterial infection and inflammation.Aging (Albany NY)20168457558810.18632/aging.100921 26961231
     [Google Scholar]
  84. TrottaT. PorroC. CalvelloR. PanaroM.A. Biological role of Toll-like receptor 4 in the brain.J. Neuroimmunol.20142681-211210.1016/j.jneuroim.2014.01.014 24529856
     [Google Scholar]
  85. MinorettiP. GazzarusoC. VitoC.D. Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer’s disease.Neurosci. Lett.2006391314714910.1016/j.neulet.2005.08.047 16157451
     [Google Scholar]
  86. WątrobaM. GrabowskaA.D. SzukiewiczD. Effects of diabetes mellitus-related dysglycemia on the functions of blood–brain barrier and the risk of dementia.Int. J. Mol. Sci.202324121006910.3390/ijms241210069 37373216
     [Google Scholar]
  87. FormoloD.A. ChengT. YuJ. KranzG.S. YauS.Y. Central adiponectin signaling a metabolic regulator in support of brain plasticity.Brain Plast.202281799610.3233/BPL‑220138 36448043
     [Google Scholar]
  88. MattsonM.P. MoehlK. GhenaN. SchmaedickM. ChengA. Intermittent metabolic switching, neuroplasticity and brain health.Nat. Rev. Neurosci.2018192819410.1038/nrn.2017.156 29321682
     [Google Scholar]
  89. WattsM.E. PocockR. ClaudianosC. Brain energy and oxygen metabolism: emerging role in normal function and disease.Front. Mol. Neurosci.20181121610.3389/fnmol.2018.00216 29988368
     [Google Scholar]
  90. HuberK. SzerenosE. LewandowskiD. ToczylowskiK. SulikA. The role of adipokines in the pathologies of the central nervous system.Int. J. Mol. Sci.202324191468410.3390/ijms241914684 37834128
     [Google Scholar]
  91. RoyP.K. IslamJ. LalhlenmawiaH. Prospects of potential adipokines as therapeutic agents in obesity-linked atherogenic dyslipidemia and insulin resistance.Egypt. Heart J.20237512410.1186/s43044‑023‑00352‑7 37014444
     [Google Scholar]
  92. BloemerJ Role of adiponectin in central nervous system disorders.Neur plast2018201810.1155/2018/4593530
     [Google Scholar]
  93. WatanabeK. WatanabeR. KoniiH. Counteractive effects of omentin-1 against atherogenesis.Cardiovasc. Res.2016110111812810.1093/cvr/cvw016 26790473
     [Google Scholar]
  94. AbduljalalM.H. Al-TalibN.A. MohialdeenS.K. Some biochemical parameters secreted from the adipose tissues.J. Educat. Sci.202332410411110.33899/edusj.2023.136498.1361
     [Google Scholar]
  95. XiangY. ZhouZ. ZhuL. LiC. LuoY. ZhouJ. Omentin-1 enhances the inhibitory effect of endothelial progenitor cells on neointimal hyperplasia by inhibiting the p38 MAPK/CREB pathway.Life Sci.202333112206110.1016/j.lfs.2023.122061 37652153
     [Google Scholar]
  96. LiZ. ZhangY. TianF. Omentin-1 promotes mitochondrial biogenesis via PGC1α-AMPK pathway in chondrocytes.Arch. Physiol. Biochem.2023129229129710.1080/13813455.2020.1819337 32930026
     [Google Scholar]
  97. CasadoM.E. Collado-PérezR. FragoL.M. BarriosV. Recent advances in the knowledge of the mechanisms of leptin physiology and actions in neurological and metabolic pathologies.Int. J. Mol. Sci.2023242142210.3390/ijms24021422 36674935
     [Google Scholar]
  98. LiY.Q. GuoC. A review on lactoferrin and central nervous system diseases.Cells2021107181010.3390/cells10071810 34359979
     [Google Scholar]
  99. FerlazzoN. AndolinaG. CannataA. Is melatonin the cornucopia of the 21st century?Antioxidants2020911108810.3390/antiox9111088 33167396
     [Google Scholar]
  100. DevaraD. ChoudharyY. KumarS. Role of MicroRNA-502-3p in human diseases.Pharmaceuticals202316453210.3390/ph16040532 37111289
     [Google Scholar]
  101. MedeirosR. Baglietto-VargasD. LaFerlaF.M. The role of tau in Alzheimer’s disease and related disorders.CNS Neurosci. Ther.201117551452410.1111/j.1755‑5949.2010.00177.x 20553310
     [Google Scholar]
  102. NasoohiS. ParveenK. IshratT. Metabolic syndrome, brain insulin resistance, and Alzheimer’s disease: Thioredoxin Interacting Protein (TXNIP) and inflammasome as core amplifiers.J. Alzheimers Dis.201866385788510.3233/JAD‑180735 30372683
     [Google Scholar]
  103. SongJ. LeeJ.E. Adiponectin as a new paradigm for approaching Alzheimer’s disease.Anat. Cell Biol.201346422923410.5115/acb.2013.46.4.229 24386594
     [Google Scholar]
  104. KangS. LeeY. LeeJ.E. Metabolism-centric overview of the pathogenesis of Alzheimer’s disease.Yonsei Med. J.201758347948810.3349/ymj.2017.58.3.479 28332351
     [Google Scholar]
  105. WuS-S Omentin-1 stimulates human osteoblast proliferation through PI3K/Akt signal pathway.Int J Endocrinol20132013
     [Google Scholar]
  106. PopaA.D. NițăO. CabaL. From the sun to the cell: Examining obesity through the lens of vitamin d and inflammation.Metabolites2023141410.3390/metabo14010004 38276294
     [Google Scholar]
  107. JoshiT. SinghA.K. HaratipourP. Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications.J. Cell. Physiol.201923410172121723110.1002/jcp.28528 30916407
     [Google Scholar]
/content/journals/cdth/10.2174/0115748855296758240408040336
Loading
Omentin 1: A Promising Regulator and Therapeutic Target in the Battle against Obesity, Diabetes, and Alzheimer’s Disease
Curr Drug Ther 20, 542 (2025); https://doi.org/10.2174/0115748855296758240408040336
/content/journals/cdth/10.2174/0115748855296758240408040336
/content/journals/cdth/10.2174/0115748855296758240408040336
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): adipokines; adipose tissue; Alzheimer's disease; diabetes; obesity; Omentin

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test