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image of Role of Phytoconstituents in Augmenting Hair Growth: A Systematic Review

Abstract

Introduction

Globally, alopecia, or hair loss, affects a significant portion of the population. Although there are synthetic medication-based treatments for alopecia, these have caused several adverse effects in many people. Since ancient times, natural products have been used and have been safe, with few negative effects, making them a suitable and effective solution for treating the condition.

Methods

A literature search was conducted in the scientific database using the keywords

“alopecia, phytoconstituents, and herbals”. This review includes a collection of reports from ScienceDirect, Scholar Google, and PubMed, all searched up to 2024. A total of 240 articles were included, with an exponential growth in the number of articles published from 2000 to 2024.

Results

It discusses different types of alopecia, such as androgenetic alopecia and

alopecia areata, scarring alopecia, delving into their mechanisms and the challenges faced

by those experiencing hair loss, including self-esteem issues and social stigma. The document details both synthetic and herbal hair loss treatments, emphasizing the advantages of herbal remedies, which typically have fewer side effects and encourage a holistic approach to hair health.

Discussion

This document provides a comprehensive overview of phytoconstituents for combating baldness, exploring key phytochemicals such as caffeine, capsaicin, and various essential oils, and highlighting their potential benefits for promoting hair growth and improving overall scalp health.

Conclusion

The document underscores the importance of herbal treatments as sustainable and effective alternatives to synthetic drugs, advocating for a more personalized approach to hair care through the use of natural remedies.

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2026-01-22
2026-02-23
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References

  1. Yu Y. Yang W. Wang B. Meyers M.A. Structure and mechanical behavior of human hair. Mater. Sci. Eng. C 2017 73 152 163 10.1016/j.msec.2016.12.008 28183593
    [Google Scholar]
  2. Cuevas-Diaz Duran R. Martinez-Ledesma E. Garcia-Garcia M. The biology and genomics of human hair follicles: A focus on androgenetic alopecia. Int. J. Mol. Sci. 2024 25 5 2542 10.3390/ijms25052542 38473791
    [Google Scholar]
  3. Kumar A. Shamim H. Nagaraju U. Premature graying of hair: Review with updates. Int. J. Trichology 2018 10 5 198 203 10.4103/ijt.ijt_47_18 30607038
    [Google Scholar]
  4. Bhushan B. Introduction—Human hair, skin, and hair care products. Biophysics of Human Hair. Berlin, Heidelberg Springer 2010 1 19 10.1007/978‑3‑642‑15901‑5_1
    [Google Scholar]
  5. Wasserman D. Guzman-Sanchez D.A. Scott K. McMichael A. Alopecia areata. Int. J. Dermatol. 2007 46 2 121 131 10.1111/j.1365‑4632.2007.03193.x 17269961
    [Google Scholar]
  6. Buffoli B. Rinaldi F. Labanca M. The human hair: From anatomy to physiology. Int. J. Dermatol. 2014 53 3 331 341 10.1111/ijd.12362 24372228
    [Google Scholar]
  7. Pauling L. Corey R.B. The structure of hair, muscle, and related proteins. Proc. Natl. Acad. Sci. USA 1951 37 5 261 271 10.1073/pnas.37.5.261 14834149
    [Google Scholar]
  8. Schlake T. Determination of hair structure and shape. Semin. Cell Dev. Biol. 2007 18 2 267 273 10.1016/j.semcdb.2007.01.005 17324597
    [Google Scholar]
  9. Atkinson P.J. Huarcaya Najarro E. Sayyid Z.N. Cheng A.G. Sensory hair cell development and regeneration: Similarities and differences. Development 2015 142 9 1561 1571 10.1242/dev.114926 25922522
    [Google Scholar]
  10. Huang Y. Mao H. Chen Y. Regeneration of hair cells in the human vestibular system. Front. Mol. Neurosci. 2022 15 854635 10.3389/fnmol.2022.854635 35401109
    [Google Scholar]
  11. Pratt C.H. King L.E. Messenger A.G. Christiano A.M. Sundberg J.P. Alopecia areata. Nat. Rev. Dis. Primers 2017 3 1 17011 10.1038/nrdp.2017.11 28300084
    [Google Scholar]
  12. Natarelli N. Gahoonia N. Sivamani R.K. Integrative and mechanistic approach to the hair growth cycle and hair loss. J. Clin. Med. 2023 12 3 893 10.3390/jcm12030893 36769541
    [Google Scholar]
  13. York K. Meah N. Bhoyrul B. Sinclair R. A review of the treatment of male pattern hair loss. Expert Opin. Pharmacother. 2020 21 5 603 612 10.1080/14656566.2020.1721463 32066284
    [Google Scholar]
  14. Sinclair R. Fortnightly review: Male pattern androgenetic alopecia. BMJ 1998 317 7162 865 869 10.1136/bmj.317.7162.865 9748188
    [Google Scholar]
  15. Hunt N. McHale S. The psychological impact of alopecia. BMJ 2005 331 7522 951 953 10.1136/bmj.331.7522.951 16239692
    [Google Scholar]
  16. Hunt N. McHALE SUE. Reported experiences of persons with alopecia areata. J. Loss Trauma 2004 10 1 33 50 10.1080/15325020490890633
    [Google Scholar]
  17. Harris D.W. Intentionalism and bald-faced lies. Inquiry 2020 1 18 10.1080/0020174X.2020.1775381
    [Google Scholar]
  18. Herman A. Herman A.P. Mechanism of action of herbs and their active constituents used in hair loss treatment. Fitoterapia 2016 114 18 25 10.1016/j.fitote.2016.08.008 27552901
    [Google Scholar]
  19. King N.Y. Mesiano D. Ahmed I. Carr R.A. A common cause of hair loss? Clin. Exp. Dermatol. 2021 46 1 203 206 10.1111/ced.14452 33031596
    [Google Scholar]
  20. Yip L. Sinclair R.D. Antiandrogen therapy for androgenetic alopecia. Expert. Rev. Dermatol. 2006 1 2 261 269 10.1586/17469872.1.2.261
    [Google Scholar]
  21. Harrison S. Sinclair R. Telogen effluvium. Clin. Exp. Dermatol. 2002 27 5 389 395 10.1046/j.1365‑2230.2002.01080.x 12190639
    [Google Scholar]
  22. Larrondo J. McMichael A.J. Traction Alopecia. JAMA Dermatol. 2023 159 6 676 10.1001/jamadermatol.2022.6298 37133879
    [Google Scholar]
  23. Sperling L.C. Scarring alopecia and the dermatopathologist. J. Cutan. Pathol. 2001 28 7 333 342 10.1034/j.1600‑0560.2001.280701.x 11437938
    [Google Scholar]
  24. Chen S. Xie X. Zhang G. Zhang Y. Comorbidities in androgenetic alopecia: A comprehensive review. Dermatol. Ther. 2022 12 10 2233 2247 10.1007/s13555‑022‑00799‑7 36115913
    [Google Scholar]
  25. Guo E.L. Katta R. Diet and hair loss: Effects of nutrient deficiency and supplement use. Dermatol. Pract. Concept. 2017 7 1 1 10 10.5826/dpc.0701a01 28243487
    [Google Scholar]
  26. Rushton D.H. Norris M.J. Dover R. Busuttil N. Causes of hair loss and the developments in hair rejuvenation. Int. J. Cosmet. Sci. 2002 24 1 17 23 10.1046/j.0412‑5463.2001.00110.x 18498491
    [Google Scholar]
  27. Alessandrini A. Bruni F. Piraccini B.M. Starace M. Common causes of hair loss – Clinical manifestations, trichoscopy and therapy. J. Eur. Acad. Dermatol. Venereol. 2021 35 3 629 640 10.1111/jdv.17079 33290611
    [Google Scholar]
  28. Ye Y. Zhao Y. Gong Y. Non-scarring patchy alopecia in patients with systemic lupus erythematosus differs from that of alopecia areata. Lupus 2013 22 14 1439 1445 10.1177/0961203313508833 24132518
    [Google Scholar]
  29. Mubki T. Use of vitamins and minerals in the treatment of hair loss: A cross-sectional survey among dermatologists in Saudi Arabia. J. Cutan. Med. Surg. 2014 18 6 405 412 10.2310/7750.2014.14008 25348762
    [Google Scholar]
  30. Abelan U.S. de Oliveira A.C. Cacoci É.S.P. Potential use of essential oils in cosmetic and dermatological hair products: A review. J. Cosmet. Dermatol. 2022 21 4 1407 1418 10.1111/jocd.14286 34129742
    [Google Scholar]
  31. Rossi A. Anzalone A. Fortuna M.C. Multi-therapies in androgenetic alopecia: Review and clinical experiences. Dermatol. Ther. 2016 29 6 424 432 10.1111/dth.12390 27424565
    [Google Scholar]
  32. Rossi A. Cantisani C. Melis L. Iorio A. Scali E. Calvieri S. Minoxidil use in dermatology, side effects and recent patents. Recent Pat. Inflamm. Allergy Drug Discov. 2012 6 2 130 136 10.2174/187221312800166859 22409453
    [Google Scholar]
  33. Abdel-Raouf H. Aly U.F. Medhat W. Ahmed S.S. Abdel-Aziz R.T.A. A novel topical combination of minoxidil and spironolactone for androgenetic alopecia: Clinical, histopathological, and physicochemical study. Dermatol. Ther. 2021 34 1 14678 10.1111/dth.14678 33320406
    [Google Scholar]
  34. Nemane S.T. Bhusnure O.G. Gholve S.B. Mitakari P.R. Karwa P.N. A review on finasteride: A 5-alpha reductase inhibitor, its mechanism, facts, and benefits. J. Drug Deliv. Ther. 2019 9 3-s 1132 1136 10.22270/jddt.v9i3‑s.3013
    [Google Scholar]
  35. Mysore V. Shashikumar B.M. Guidelines on the use of finasteride in androgenetic alopecia. Indian J. Dermatol. Venereol. Leprol. 2016 82 2 128 134 10.4103/0378‑6323.177432 26924401
    [Google Scholar]
  36. Fields J.R. Vonu P.M. Monir R.L. Schoch J.J. Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review. Dermatol. Ther. 2020 33 1 13202 10.1111/dth.13202 31858672
    [Google Scholar]
  37. Van Tyle J.H. Ketoconazole. Mechanism of action, spectrum of activity, pharmacokinetics, drug interactions, adverse reactions and therapeutic use. Pharmacotherapy 1984 4 6 343 373 10.1002/j.1875‑9114.1984.tb03398.x 6151171
    [Google Scholar]
  38. Arif T. Dorjay K. Adil M. Sami M. Dutasteride in androgenetic alopecia: An update. Curr. Clin. Pharmacol. 2017 12 1 31 35 10.2174/1574884712666170310111125 28294070
    [Google Scholar]
  39. Sinclair R Patel M Dawson TL Hair loss in women: Medical and cosmetic approaches to increase scalp hair fullness. Br J Dermatol 2011 165 12 8.(Suppl. 3) 10.1111/j.1365‑2133.2011.10630.x 22171680
    [Google Scholar]
  40. Efentaki P. Altenburg A. Haerting J. Zouboulis C.C. Medium-dose prednisolone pulse therapy in alopecia areata. Dermatoendocrinol 2009 1 6 311 314 10.4161/derm.1.6.11236 21572877
    [Google Scholar]
  41. Lai V.W.Y. Chen G. Gin D. Sinclair R. Systemic treatments for alopecia areata: A systematic review. Australas. J. Dermatol. 2019 60 1 e1 e13 10.1111/ajd.12913 30191561
    [Google Scholar]
  42. Carmina E. Lobo R.A. Treatment of hyperandrogenic alopecia in women. Fertil. Steril. 2003 79 1 91 95 10.1016/S0015‑0282(02)04551‑X 12524069
    [Google Scholar]
  43. Ellis C.N. Brown M.F. Voorhees J.J. Sulfasalazine for alopecia areata. J. Am. Acad. Dermatol. 2002 46 4 541 544 10.1067/mjd.2002.119671 11907504
    [Google Scholar]
  44. Vincenti M. Kintz P. New challenges and perspectives in hair analysis. Hair Analysis in Clinical and Forensic Toxicology. Elsevier 2015 337 368 10.1016/B978‑0‑12‑801700‑5.00012‑1
    [Google Scholar]
  45. Sharma A.N. Michelle L. Juhasz M. Muller Ramos P. Atanaskova Mesinkovska N. Low‐dose oral minoxidil as treatment for non‐scarring alopecia: A systematic review. Int. J. Dermatol. 2020 59 8 1013 1019 10.1111/ijd.14933 32516434
    [Google Scholar]
  46. Ali S. Nisar M. Iriti M. Biotransformation of Finasteride by Ocimum sanctum L., and tyrosinase inhibitory activity of transformed metabolites: Experimental and computational insights. Steroids 2014 92 20 24 10.1016/j.steroids.2014.07.007 25159102
    [Google Scholar]
  47. Wang C. Du Y. Bi L. Lin X. Zhao M. Fan W. The efficacy and safety of oral and topical spironolactone in androgenetic alopecia treatment: A systematic review. Clin. Cosmet. Investig. Dermatol. 2023 16 603 612 10.2147/CCID.S398950 36923692
    [Google Scholar]
  48. Dhariwala M.Y. Ravikumar P. An overview of herbal alternatives in androgenetic alopecia. J. Cosmet. Dermatol. 2019 18 4 966 975 10.1111/jocd.12930 30980598
    [Google Scholar]
  49. Bansal M. Manchanda K. Pandey S.S. Role of caffeine in the management of androgenetic alopecia. Int. J. Trichology 2012 4 3 185 186 10.4103/0974‑7753.100096 23180935
    [Google Scholar]
  50. Mao Y. Xu Z. Song J. Xie Y. Mei X. Shi W. Efficacy of a mixed preparation containing piperine, capsaicin and curcumin in the treatment of alopecia areata. J. Cosmet. Dermatol. 2022 21 10 4510 4514 10.1111/jocd.14931 35318791
    [Google Scholar]
  51. Yeniay Y. Arca E. Evaluation of the efficacy and safety of topical procyanidin b2 and placebo in the treatment of androgenetic alopecia in men; A randomized, double-blind, placebo-controlled study. Turk Dermatol. Derg. 2022 16 4 108 10.4103/tjd.tjd_41_22
    [Google Scholar]
  52. Sharquie K.E. Al-Obaidi H.K. Onion juice (Allium cepa L.), a new topical treatment for alopecia areata. J. Dermatol. 2002 29 6 343 346 10.1111/j.1346‑8138.2002.tb00277.x 12126069
    [Google Scholar]
  53. Cho Y.H. Lee S.Y. Jeong D.W. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: A randomized, double-blind, placebo-controlled trial. Evid. Based Complement. Alternat. Med. 2014 2014 1 549721 10.1155/2014/549721 24864154
    [Google Scholar]
  54. Evron E. Juhasz M. Babadjouni A. Mesinkovska N.A. Natural hair supplement: Friend or foe? Saw palmetto, a systematic review of alopecia. Skin Appendage Disord. 2020 6 6 329 337 10.1159/000509905 33313047
    [Google Scholar]
  55. Oh G.N. Son S.W. Efficacy of korean red ginseng in the treatment of alopecia areata. J. Ginseng Res. 2012 36 4 391 395 10.5142/jgr.2012.36.4.391 23717141
    [Google Scholar]
  56. Di Lorenzo R. Forgione F. Bernardi A. Sacchi A. Laneri S. Greco G. Clinical studies on topical curcumin. Skin Pharmacol. Physiol. 2023 36 5 235 248 10.1159/000535100 38008088
    [Google Scholar]
  57. Li Y. Sheng Y. Liu J. Hair-growth promoting effect and anti-inflammatory mechanism of Ginkgo biloba polysaccharides. Carbohydr. Polym. 2022 278 118811 10.1016/j.carbpol.2021.118811 34973721
    [Google Scholar]
  58. Wongrakpanich A. Leanpolchareanchai J. Morakul B. Parichatikanond W. Teeranachaideekul V. Extract-loaded transfersomes for hair follicle targeting: Phytoconstituents, characterization, and hair growth promotion. J. Oleo Sci. 2022 71 7 1085 1096 10.5650/jos.ess21425 35781257
    [Google Scholar]
  59. Adamovic M. Adamovic A. Andjic M. The botany, phytochemistry, and the effects of the Juglans regia on healthy and diseased skin. Cosmetics 2024 11 5 163 10.3390/cosmetics11050163
    [Google Scholar]
  60. Padule K. Shinde S. Chitlange S. Giram P. Nagore D. The advancement of herbal-based nanomedicine for hair. Cosmetics 2022 9 6 118 10.3390/cosmetics9060118
    [Google Scholar]
  61. Suman K.G. Kumar B. Mukopadayay S. Herbal hair oil. Int. J. Health Sci. 2022 6 13449 13465 10.53730/ijhs.v6nS2.8537
    [Google Scholar]
  62. Pham C.T. Romero K. Almohanna H.M. Griggs J. Ahmed A. Tosti A. The role of diet as an adjuvant treatment in scarring and non-scarring. Skin Appendage Disord. 2020 6 2 88 96 10.1159/000504786 32258051
    [Google Scholar]
  63. Urysiak-Czubatka I. Kmieć M.L. Broniarczyk-Dyła G. Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia. Postepy Dermatol. Alergol. 2014 4 4 207 215 10.5114/pdia.2014.40925 25254005
    [Google Scholar]
  64. Srivilai J. Phimnuan P. Jaisabai J. Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae; a randomised, double blinded trial. Phytomedicine 2017 25 29 38 10.1016/j.phymed.2016.12.007 28190468
    [Google Scholar]
  65. Hosking A.M. Juhasz M. Atanaskova Mesinkovska N. Complementary and alternative treatments for alopecia: A comprehensive review. Skin Appendage Disord. 2019 5 2 72 89 10.1159/000492035 30815439
    [Google Scholar]
  66. Rebora A. Pathogenesis of androgenetic alopecia. J. Am. Acad. Dermatol. 2004 50 5 777 779 10.1016/j.jaad.2003.11.073 15097964
    [Google Scholar]
  67. Khandagale S.S. Ratnaparkhe C.L. Sayyad S.R. Shelar V.D. Supekar A.V. Sarukh V.S. A review of herbal medications for the treatment of alopecia. Int. J. Ayurveda Pharma Res. 2023 11 7 5 10 10.47070/ijapr.v11iSuppl4.2974
    [Google Scholar]
  68. Ozmen I. Caliskan E. Arca E. Acikgoz G. Koc E. Efficacy of aromatherapy in the treatment of localized alopecia areata: A double-blind placebo controlled study. Gülhane Tip Derg. 2015 57 3 233 10.5455/gulhane.38258
    [Google Scholar]
  69. Ghosh P. Biswas S. Biswas M. Dutta A. Sil S. Chatterjee S. Morphological, ethno-biological and phytopharmacological attributes of Tridax procumbens Linn. (Asteraceae): A review. Int J Sci Res Biol Sci 2019 6 2 182 191 10.26438/ijsrbs/v6i2.182191
    [Google Scholar]
  70. Cho E.C. Kim K. A comprehensive review of biochemical factors in herbs and their constituent compounds in experimental studies on alopecia. J. Ethnopharmacol. 2020 258 112907 10.1016/j.jep.2020.112907 32360043
    [Google Scholar]
  71. Patel S. Sharma V. Chauhan N. Thakur M. Dixit V.K. Hair growth: Focus on the herbal therapeutic agent. Curr. Drug Discov. Technol. 2015 12 1 21 42 10.2174/1570163812666150610115055 26058803
    [Google Scholar]
  72. Gottumukkala V. Annamalai T. Mukhopadhyay T. Phytochemical investigation and hair growth studies on the rhizomes of Nardostachys jatamansi DC. Pharmacogn. Mag. 2011 7 26 146 150 10.4103/0973‑1296.80674 21716625
    [Google Scholar]
  73. Jain N. Valli K.S. Devi V.K. Importance of novel drug delivery systems in herbal medicines. Pharmacogn. Rev. 2010 4 7 27 31 10.4103/0973‑7847.65322 22228938
    [Google Scholar]
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  • Article Type:
    Review Article
Keywords: Hairs ; hair growth ; phytoconstituents ; physiology ; herbals ; alopecia
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