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image of Role of Antioxidants in Diseases and its Impact on Mitochondria with A Focus on Diabetes: An Overview

Abstract

Introduction

This review focuses on the various natural and synthetic antioxidants which affect cellular signalling and mitochondrial dynamics for managing diabetes and its complications including other variety of diseases or traumas.

Methods

Information in the current review was gathered from electronic scientific resources like google scholar, science direct, springer link and the PubMed website using the Boolean Method and a variety of keywords.

Results

The results of the present study revealed that a number of 110 antioxidants have been identified to improve mitochondrial health, offering potential treatments for diabetes and a spectrum of other diseases. Naturally occurring antioxidants such as polyphenols and flavonoids present in fruits and plants, have demonstrated the ability to attenuate oxidative stress and enhance mitochondrial performance thereby helps in the management of diabetes and various other health complications. From among the polyphenol’s resveratrol, mitoQ, quercetin and curcumin has been discussed in the review.

Discussion

The analysis indicates a strong correlation between antioxidant activity and mitochondrial function, underscoring their role in disease prevention and therapy. These antioxidants not only reduce oxidative damage but also regulate signalling pathways involved in inflammation and energy metabolism. Their dual action makes them promising agents in managing diabetes and potentially other chronic diseases.

Conclusion

The conclusion offers a concise yet comprehensive overview for researchers and industries in highlighting the therapeutic promise of antioxidant interventions in addressing diverse health conditions through enhanced mitochondrial function.

© 2025 Bentham Science Publishers
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2025-07-23
2025-09-05

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/content/journals/cdrr/10.2174/0125899775370658250713030329
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Role of Antioxidants in Diseases and its Impact on Mitochondria with A Focus on Diabetes: An Overview
Bentham Science Publishers ; https://doi.org/10.2174/0125899775370658250713030329
/content/journals/cdrr/10.2174/0125899775370658250713030329
/content/journals/cdrr/10.2174/0125899775370658250713030329
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  • Article Type:     Review Article
Keywords: Antioxidants ; polyphenols ; mitochondrial dysfunction ; diabetes

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