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image of Mechanism of Herbal Pairs Modulating Endogenous Melatonin to Ameliorate Sleep Disorders: Data Mining, Network Pharmacology and Meta-Analysis

Abstract

Introduction

Sleep disorders (SD) affect approximately 25% of the global population. Traditional Chinese Medicine (TCM) formulas have been shown to alleviate SD by modulating endogenous melatonin. This study used data mining, network pharmacology, and meta-analysis to identify key herbal pairs from TCM formulas and the mechanism of action.

Methods

Literature was retrieved from PubMed, Web of Science, Embase, Cochrane Library, CNKI, Wanfang Data Information Site, China Science and Technology Journal Database, and SinoMed. R was used for frequency and association rule analysis, SPSS for clustering, and Cytoscape, STRING, Gene Ontology, and KEGG enrichment analyses were utilized to explore targets, protein-protein interactions, and pathways. A meta-analysis using the Metan command was performed to assess the optimal herbal pairs for SD treatment.

Results

Data mining identified 77 commonly used herbs, revealing four advantageous herbal pairs: . Network pharmacology showed that (PRA-BR)-SD, (PA-BR)-SD, (CR-CC)-SD, and (ZSS-MC)-SD targeted CACNA1D, GRIN2A, AGT, and ATP1A1 prion diseases, nicotine addiction, neuroactive ligand-receptor interaction, and cardiac muscle contraction pathways, respectively.

Discussion

Research shows that CACNA1D could regulate Ca2+ inward flow, avoid mitochondrial dysfunction in prion diseases, and reduce ROS generation, thus indirectly maintaining MT levels and sleep. GRIN2A as an amygdala hub gene closely related to daily smoking, combining brain transcriptome analysis and tobacco consumption GWAS data. The sleep regulation mechanism of MT relies on the neuroactive ligand-receptor pathway. As a neuroactive ligand, MT triggers sleep-promoting physiological responses by activating the G-protein-coupled receptors MT and MT and transmitting “night” signals to the relevant neural networks. Insufficient MT secretion or circadian rhythm disruption might lead to abnormal blood pressure rhythms accompanied by sympathetic overactivation, increasing the risk of insomnia and cardiovascular disease. ATP1A1 is a key molecule in the maintenance of electrochemical gradients in cardiac myocytes through the modulation of the Na+/K+ homeostasis affects myocardial excitability, calcium kinetics, and contractile function.

Conclusion

Meta-analysis and network pharmacology suggest that the PA-BR pair might offer superior efficacy by modulating membrane potential and nicotine addiction pathways, targeting GRIN2A, GRIN1, GRIN3A, and GRIN2B to regulate melatonin levels.

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/content/journals/cchts/10.2174/0113862073393993250930120235
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Mechanism of Herbal Pairs Modulating Endogenous Melatonin to Ameliorate Sleep Disorders: Data Mining, Network Pharmacology and Meta-Analysis
Bentham Science Publishers ; https://doi.org/10.2174/0113862073393993250930120235
/content/journals/cchts/10.2174/0113862073393993250930120235
/content/journals/cchts/10.2174/0113862073393993250930120235
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  • Article Type:     Research Article
Keywords: melatonin ; network pharmacology ; Sleep disorders ; traditional chinese medicine ; meta analysis ; data mining

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