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2000
Volume 12, Issue 8
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

The analysis of biomolecular interactions is key in the drug development process. Label-free biosensor methods provide information on binding, kinetics, concentration, and the affinity of an interaction. These techniques provide real-time monitoring of interactions between an immobilized ligand (such as a receptor) to an analyte in solution without the use of labels. Advances in biosensor design and detection using BioLayer Interferometry (BLI) provide a simple platform that enables label-free monitoring of biomolecular interactions without the use of flow cells. We review the applications of BLI in a wide variety of research and development environments for quantifying antibodies and proteins and measuring kinetics parameters.

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/content/journals/cchts/10.2174/138620709789104915
2009-09-01
2024-12-09
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  • Article Type:
    Research Article
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