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2000
Volume 28, Issue 19
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

The discovery of novel counteractive pharmaceuticals, which have recently generated much interest, has played a significant role in the development of drugs derived from herbal medicines or botanical sources. () is one such example of a role in both traditional and traditional medicine. Owing to its popularity in folk medicine, it has been the subject of intense pharmacological and chemical studies for the last 30 years. They are locally known as “Gandhavadulia” or “GandhaPrasarini” (English name “skunkvine”) and belong to the family Rubiaceae. This plant has a broad range of applications in the treatment of several illnesses, including anti-inflammatory, antinociceptive, antitussive, thrombolytic, antidiabetic, antihyperlipidaemic, antioxidant, nephroprotective, anti-inflammatory, hepatoprotective, anthelmintic, and antidiarrheal effects. Additionally, it contains a variety of phytochemicals, such as asperuloside, paederosidic acid, sitosterols, campesterol, lignans, alkaloids, volatile oils, iridoids, methylindooxy substances, stigmasterol, tannins, triterpenoids, ellagic acid, ursolic acid, epifriedelinol, and phenolic compounds. Recently, mounting data on numerous active ingredients have indicated that they may be beneficial for spermatogenesis, wound healing, inflammatory illnesses, and cancer. This review describes the phytochemistry and mechanisms of action of these pharmacological effects and provides insights into potential pharmacological targets. These results highlight the need for additional studies on this medicinal plant and the investigation of new counteractive medications to determine their mode of action before use in healthcare.

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References

  1. WadudM.A. AkhterR. ChowdhuryS.F. NarjishS.N. MannanM.M. NasiruddinM.M. ShahriarM. BhuiyanM.A. In vivo pharmacological investigations of leaf extracts of Paederia foetida (L.).Int. J. Pharm. Sci. Rev. Res.2015312166172
     [Google Scholar]
  2. KhushbuC. AnarP. MayureeP. CarolM. RoshniS. SubodhA. Paederia foetida Linn. As a potential medicinal plant: A Review.J. Pharm. Res.201031231353137
     [Google Scholar]
  3. KumarV. AnwarF. AhmedD. VermaA. AhmedA. DamanhouriZ.A. MishraV. RamtekeP.W. BhattP.C. MujeebM. Paederia foetida Linn. leaf extract: An antihyperlipidemic, antihyperglycaemic and antioxidant activity.BMC Complement. Altern. Med.20141417610.1186/1472‑6882‑14‑76 24564866
     [Google Scholar]
  4. SoniR.K. IrchhaiyaR. DixitV. AlokS. Paederia foetida Linn: Phytochemistry, pharmacological and traditional uses.Int. J. Pharm. Sci. Res.2013412452510.13040/IJPSR.0975‑8232.4(12).4525‑30
     [Google Scholar]
  5. DuttaP.P. MarbaniangK. SenS. DeyB.K. TalukdarN.C. A review on phytochemistry of Paederia foetida Linn.Phytomed. Plus20233110041110.1016/j.phyplu.2023.100411
     [Google Scholar]
  6. YadavV.K. KumarS.P. SinghU.P. BhatH.R. ZamanM.K. Pharmacognostical and phytochemical study on the leaves of Paederia foetida linn.Int. J. Pharmaceut. Res.20092918920
     [Google Scholar]
  7. AfrozS. AlamgirM. KhanM.T.H. JabbarS. NaharN. ChoudhuriM.S.K. Antidiarrhoeal activity of the ethanol extract of Paederia foetida Linn. (Rubiaceae).J. Ethnopharmacol.20061051-212513010.1016/j.jep.2005.10.004 16298094
     [Google Scholar]
  8. KumarV. Al-AbbasiF.A. AhmedD. VermaA. MujeebM. AnwarF. Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE 2 and COX-2 expression via nuclear factor-κB.Food Funct.2015651652166610.1039/C5FO00178A 25893742
     [Google Scholar]
  9. ChungY.C. LeeJ.N. KimB.S. HyunC.G. Anti-melanogenic effects of Paederia foetida L. extract via MAPK signaling-mediated MITF downregulation.Cosmetics2021812210.3390/cosmetics8010022
     [Google Scholar]
  10. SarmaM.K. SahaD. DasB.K. DasT. AzizovS. KumarD. A delve into the pharmacological targets and biological mechanisms of Paederia foetida Linn.: A rather invaluable traditional medicinal plant.Naunyn Schmiedebergs Arch. Pharmacol.2023396102217224010.1007/s00210‑023‑02496‑4 37099165
     [Google Scholar]
  11. PriyantoJ.A. PrastyaM.E. SinarawadiG.S. Datu’salamahW. AvelinaT.Y. YanuarA.I.A. AzizahE. TachrimZ.P. MozefT. The antibacterial and antibiofilm potential of Paederia foetida Linn. leaves extract.J. Appl. Pharm. Sci.2022121011712410.7324/JAPS.2022.121012
     [Google Scholar]
  12. UpadhyayaS. Screening of phytochemicals, nutritional status, antioxidant and antimicrobial activity of Paederia foetida Linn. from different localities of Assam, India.J. Pharm. Res.20137113914110.1016/j.jopr.2013.01.015
     [Google Scholar]
  13. BoseP.K. BanerjeeA.K. GhoshC. Chemical investigation of Paederia foetida Linn.Transac. Bose Res. Inst.1953197778
     [Google Scholar]
  14. HakimA. DasS. KanodiaL. MukherjeeA. Effect of ethanolic extract of leaves of Paederia foetida Linn. on acetic acid induced colitis in albino rats.Indian J. Pharmacol.201345545345710.4103/0253‑7613.117728 24130378
     [Google Scholar]
  15. Rindita, HananiE. SaidahN. Pharmacognostical, preliminary phytochemical evaluation and flavonoids content of Paederia foetida Linn.Res. J. Pharmacog. Phytochem.2019112818610.5958/0975‑4385.2019.00015.3
     [Google Scholar]
  16. DeS. RavishankarB. BhavsarG.C. Investigation of the anti-inflammatory effects of Paederia foetida.J. Ethnopharmacol.1994431313810.1016/0378‑8741(94)90113‑9 7967647
     [Google Scholar]
  17. KarmakarU. AkterS. SultanaS. Investigation of anti-oxidant, analgesic, anti-microbial, and anthelmintic activity of the aerial parts of Paederia foetida (Family: Rubiaceaea).Jordan J. Pharm. Sci.2020132
     [Google Scholar]
  18. ChandaS. DebL. TiwariR.K. SinghK. AhmadS. Gastroprotective mechanism of Paederia foetida Linn. (Rubiaceae) - A popular edible plant used by the tribal community of North-East India.BMC Complement. Altern. Med.201515130410.1186/s12906‑015‑0831‑0 26335308
     [Google Scholar]
  19. MorshedH. IslamM.S. ParvinS. AhmedM.U. IslamM.S. MostofaA.G. SayeedM.S. Anti-microbial and cytotoxic activity of the methanol extract of Paederia foetida Linn.(Rubiaceae).J. Appl. Pharmaceut. Sci.201220127780
     [Google Scholar]
  20. SatapathyS. PattnaikG. Preliminary phytochemical screening and FTIR analysis of an Indian medicinal herb: Paederia Foetida (Prasarini).Indian J. Public Health Res. Dev.202011164164610.37506/v11/i1/2020/ijphrd/193895
     [Google Scholar]
  21. BorgohainM.P. ChowdhuryL. AhmedS. BolshetteN. DevasaniK. DasT.J. MohapatraA. LahkarM. Renoprotective and antioxidative effects of methanolic Paederia foetida leaf extract on experimental diabetic nephropathy in rats.J. Ethnopharmacol.201719845145910.1016/j.jep.2017.01.035 28111217
     [Google Scholar]
  22. GuptaR.C. AnsariM.S. KupoorL.D. Pharmacognostical studies on Paederia foetida Linn.Q. J. Crude Drug Res.19711111697171110.3109/13880207109066243
     [Google Scholar]
  23. BhuyanB. PaulA. PaulB. DharS.S. DuttaP. Paederia foetida Linn. promoted biogenic gold and silver nanoparticles: Synthesis, characterization, photocatalytic and in vitro efficacy against clinically isolated pathogens.J. Photochem. Photobiol. B201717321021510.1016/j.jphotobiol.2017.05.040 28599238
     [Google Scholar]
  24. ChandaS. SarethyI.P. DeB. SinghK. Paederia foetida - A promising ethno-medicinal tribal plant of northeastern India.J. For. Res.201324480180810.1007/s11676‑013‑0369‑2
     [Google Scholar]
  25. TanD.C. QuekA. KassimN.K. IsmailI.S. LeeJ.J. Rapid quantification and validation of biomarker scopoletin in Paederia foetida by qNMR and UV–Vis for herbal preparation.Molecules20202521516210.3390/molecules25215162 33171900
     [Google Scholar]
  26. GamS. DekaD. DasB. SarmaD. KumarS. KushariS. SaikiaA. SarmaH. Ethnobotanical review of medicinal plants used against diarrhea and dysentery in northeast India (Assam).Curr. Tradit. Med.202176e29102119746310.2174/2215083807666211029104102
     [Google Scholar]
  27. OjhaS. RajA. RoyA. RoyS. Extraction of total phenolics, flavonoids and tannins from Paederia foetida L. Leaves and their relation with antioxidant activity.Pharmacogn. J.201810354154710.5530/pj.2018.3.88
     [Google Scholar]
  28. SoniD.K. SharmaV. ChauhanN.S. DixitV.K. Effect of ethanolic extract of Paederia foetida Linn. leaves on sexual behavior and spermatogenesis in male rats.J. Men’s Health20129426827610.1016/j.jomh.2011.12.003
     [Google Scholar]
  29. DwivediJ. SachanP. WalP. KoseyS. Progressive journey of phytosomes: Preparation, characterization, patents, clinical trials & commercial products.J. Res. Pharm.2023275
     [Google Scholar]
  30. RamadhanA. WardaniA.K. DlaminiB.S. ChangC.I. Anthraquinone derivatives and its antibacterial properties from Paederia foetida stems.Nat. Prod. J.202111219319910.2174/2210315510666191224103057
     [Google Scholar]
  31. UddinB. NaharT. KhalilM.I. HossainS. In vitro antibacterial activity of the ethanol extract of Paederia foetida L.(Rubiaceae) leaves. Bangladesh.J. Life Sci.2007192141143
     [Google Scholar]
  32. RoyP. DasH. AliM.S. SarkarP. ChattopadhyayS. A review on Paederia foetida as a medicinal plant and it’s pharmacological activities.World J. Pharm. Pharm. Sci.20211012637647
     [Google Scholar]
  33. RosliN.H. TajuddinN.A. ShafieS. Preliminary study: Vitamin C in Paederia foetida leaves.Open Conf. Proceed. J.20134191110.2174/2210289201304020009
     [Google Scholar]
  34. PakaprotN. KhamphayaT. KwankaewP. NinsuwanS. LaisunthadS. ThonoiK. KuraeiadS. Neuroprotective effects of Paederia foetida Linn. on scopolamine-induced cognitive impairment in rats.Vet. World20241791972198210.14202/vetworld.2024.1972‑1982
     [Google Scholar]
  35. SultanaC. KundoN. IslamS. AhmedR. AfrinS. SaqueebN. Ibne WahedM.I. Antioxidant, analgesic and antimicrobial activities of different fractions from methanolic extract of Psidium guajava L. Leaves.Int. J. Pharm. Sci. Res.2020116273310.13040/IJPSR.0975‑8232.11(6).2733‑38
     [Google Scholar]
  36. BhuyanB. PaulB. PaulA. DharS.S. Paederia foetida Linn. promoted synthesis of CoFe2 O4 and NiFe2 O4 nanostructures and their photocatalytic efficiency.IET Nanobiotechnol.201812323524010.1049/iet‑nbt.2017.0131
     [Google Scholar]
  37. ChandaS. AhmadS. SinghK. TiwariR.K. Targeted metabolite analysis of Iridoids of paederia foetida : A popular tribal edible plant of northeast, India.Asian J. Chem.20172981713171710.14233/ajchem.2017.20585
     [Google Scholar]
  38. SahooM. BhatnagarS. A comparative analysis of phytochemical and antioxidant profile of Paedaria foetida L wild and cultivated varieties.World J. Pharm. Res.20155113291337
     [Google Scholar]
  39. PriyantoJ.A. PrastyaM.E. PrimahanaG. RandyA. UtamiD.T. Paederia foetida Linn leaves-derived extract showed anti-oxidant and cytotoxic properties against breast carcinoma cell.Hayati J. Biosci.202230227128010.4308/hjb.30.2.271‑280
     [Google Scholar]
  40. MiliS. KonwarA. KalitaJ.C. Phytochemical Profile and GC-MS Analysis of Paederia foetida: Unveiling the Bioactive Compounds.Afr. J. Biomed. Res.2024271S22082216
     [Google Scholar]
  41. SottirattanapanP. NantachaiK. DaduangS. FunahashiT. YamadaM. Purification and characterization of amylase from roots of Paederia foetida Linn.Biocatal. Agric. Biotechnol.20171032933510.1016/j.bcab.2017.04.012
     [Google Scholar]
  42. OsmanH. RahimA.A. IsaN.M. BakhirN.M. Antioxidant activity and phenolic content of Paederia foetida and Syzygium aqueum.Molecules200914397097810.3390/molecules14030970 19305354
     [Google Scholar]
  43. SandeepS. DineshK.C. SharmaI.P. AnandarajagopalK. Pharmacognostical profile of Paederia foetida Linn. leaves.Int. J. Pharm. Sci. Res.20123720752081
     [Google Scholar]
  44. KhamphayaT. PouyfungP. YimthiangS. KotepuiM. KuraeiadS. Ameliorative effects of Paederia foetida Linn. on lead acetate-exposed rats.J. Appl. Pharm. Sci.2022123160170
     [Google Scholar]
  45. SharmaM. DwivediJ. KumarB. SinghB. RawatA.K. Plant-Based Secondary Metabolites for Health Benefits: Classification and Processing.Phytochemicals from Medicinal Plants.Apple Academic Press2019336410.1201/9780429203220‑3
     [Google Scholar]
  46. MazumderK. DeyZ.K. DeyS. HossainS. SajonS.R. HossainK.M.D. Phytochemical screening &evaluation of ant diarrheal mode of action of leaves extracts of Paederia foetida linn.Int. J. Complement. Altern. Med.201811430430910.15406/ijcam.2018.11.00416
     [Google Scholar]
  47. RajashekharaN. VasanthP. KumarD.V. A comparative analytical study of Prasarani (Merremia tridentata Hallier. f. and Paederia foetida Linn.).Ayu201233344444610.4103/0974‑8520.108864 23723657
     [Google Scholar]
  48. RutnakornpitukB. BoonlueS. Investigation of anti-oxidant activity of active compounds in ethyl acetate crude extract from stem of Paederia foetida Linn. NU.Int. J. Sci.20131013847
     [Google Scholar]
  49. DasB.P. GhoshA. Medicinal properties of phyto-constituents from Rubiaceae family of Assam: Critical review.Int. J. Appl. Chem. Biolog. Sci.202013125
     [Google Scholar]
  50. DwivediJ. GuptaA. VermaS. PaliwalS. RawatA.K.S. Validated simultaneous high-performance thin-layer chromatographic analysis of ursolic acid, β -sitosterol, lupeol and quercetin in the methanolic fraction of Ichnocarpus frutescens.J. Planar Chromatogr. Mod. TLC201932210310810.1556/1006.2019.32.2.4
     [Google Scholar]
  51. SatapathyS. PattnaikG. Evaluation of antibacterial properties and GCMS analysis of an indian medicinal herb: Paederia foetida (Prasarini).Int. J. Contemp. Microbiol.201952
     [Google Scholar]
  52. KhanS. ZahanD. DasR. NasrinD. AhsanS. AhmedR. SadatA.F. BasharA.B. NaharN. RahmatullahM. Antihyperglycemic activity studies with methanol extract of Madhuca indica JF Gmel. leaves and Paederia foetida L. stems in mice.Adv Nat Appl Sci.201152122126
     [Google Scholar]
  53. HusnaT. Mohi-Ud-DinM. HasanM.M. NazranA. KhanH.I. HassanJ. ShovonM.N.H. GhoshT.K. Comparative analysis of antioxidant potential in leaf, stem, and root of Paederia foetida L.Acta Agric. Slov.202311921510.14720/aas.2023.119.2.13320
     [Google Scholar]
  54. DwivediJ. DwivediM. GuptaS. JadaunV. YadavB. ParasharP. DharP. DwivediP. AhmedH. SinghP. PalA. PaliwalS.K. DwivediA.K. RawatA.K.S. Synthesized phytomolecular hybrids as natural interventions to manage hyperlipidemia and to ameliorate diabetes in streptozotocin induced mice.Polycycl. Aromat. Compd.20224296136615410.1080/10406638.2021.1982731
     [Google Scholar]
  55. BandiyaM. DashoraK. SisodiyaD. Anti-inflammatory activity of Paederia foetida linn in carrageenan induced rat paw edema. AGPE.Res. J. Hist. Sci. Econ. Polit. Social Sci.20223818
     [Google Scholar]
  56. UddinB. NaharT. AhmedB.M. HossanT. ChoudhuryM.S. HossainS. Ameliorative effects of Paederia foetida Linn.(Rubiaceae) extract on hepatotoxin-induced liver damage.Bangladesh J. Life Sci.20102225763
     [Google Scholar]
  57. NayakR. PandaA. PradhanC. SamantaL. SahooS. Characterization of anti-oxidant potential of Abutilon indicum L. and Paederia foetida L.Int. J. Sci. Technol. Manage.20154495104
     [Google Scholar]
  58. SarmaR. GhimireN. RahmanO. JamirL. ChaudharyS.K. SinghS. BhatH.R. GhoshS.K. ShakyaA. Subchronic toxicity study of the characterized hydroalcoholic extract of Paederia foetida (L.) leaves in swiss albino mice.S. Afr. J. Bot.202215154455410.1016/j.sajb.2022.10.037
     [Google Scholar]
  59. SantajitS. TunyongW. HorpetD. BinmutA. Kong-NgoenT. WisessaowapakC. ThavorasakT. PumiratP. IndrawattanaN. Unveiling the antimicrobial, anti-biofilm, and anti-quorum-sensing potential of Paederia foetida Linn. Leaf extract against Staphylococcus aureus: An integrated in vitro–in silico investigation.Antibiotics (Basel)202413761310.3390/antibiotics13070613 39061295
     [Google Scholar]
  60. BeheraB. SinhaP. GoudaS. RathS.K. BarikD.P. JenaP.K. PandaP.C. NaikS.K. In vitro propagation by axillary shoot proliferation, assessment of antioxidant activity, and genetic fidelity of micropropagated Paederia foetida L.J. Appl. Biol. Biotechnol.201862414910.7324/JABB.2018.60207
     [Google Scholar]
  61. MollickM.M.R. BhowmickB. MaityD. MondalD. BainM.K. BankuraK. SarkarJ. RanaD. AcharyaK. ChattopadhyayD. Green synthesis of silver nanoparticles using Paederia foetida L. leaf extract and assessment of their anti-microbial activities.Int. J. Green Nanotechnol.20124323023910.1080/19430892.2012.706103
     [Google Scholar]
  62. IsmawatiI. DestryanaR.A. HuzaimahN. Imunitas udang vanname (Litopenaeus vannamei) yang diberi pakan tambahan daun kasembukan (Paederia foetida Linn.).Indonesian J. Marine Sci. Technol.2019122201206
     [Google Scholar]
  63. UddinB. NaharT. BasuniaM.A. HossainS. Paederia foetida protects liver against hepatotoxin-induced oxidative damage.Adv. Biol. Res.201155267272
     [Google Scholar]
  64. GeJ. XueR. SunW. ChenG. Analyzing fetid odors from Paederia foetida Linn. and chicken manure and deciphering their educational functions.Zhiwu Kexue Xuebao2016346934940
     [Google Scholar]
  65. RoyS. GhoshS. PramanickK. RoyP. MajumdarM. RoyS. Preclinical evaluation of Paederia foetida leaves for burn wound healing activity.Research Journal of Pharmacy and Technology20241741727173010.52711/0974‑360X.2024.00274
     [Google Scholar]
  66. NugrohoR.A. NopriantiD. SudiastutiS. Pengaruh ekstrak air daun sembukan (Paederia foetida linn.) terhadap morfometri dan kelulushidupan fetus mencit (Mus musculus l.).Jurnal Biota201842495310.19109/Biota.v4i2.2109
     [Google Scholar]
  67. MoharanaM. PattanayakS.K. KhanF. Identification of novel potential hepatitis E virus inhibitors as seen from molecular docking, free energy landscape and molecular dynamics simulation studies.Mol. Simul.2023491096798110.1080/08927022.2023.2202764
     [Google Scholar]
  68. SaikiaR.R. BorpuzariT. HazarikaM. NathR. SharmaA.K. Phytoingredients as a natural source of anti-oxidant in masala paneer.IJCS20197545314536
     [Google Scholar]
  69. NopriantiD. NugrohoR.A. Effect of healed leaf water extract (Paederia foetida Linn.) on morphometry and survival of mice fetus (Mus musculus L.). J.Biota.2018424953
     [Google Scholar]
  70. BhuyanB. PaulA. DeviM. DharS.S. A silver NP-dispersed water extract of fly ash as a green and efficient medium for oxidant-free dehydrogenation of benzyl alcohols.RSC Adv.2018831313131910.1039/C7RA12225J 35540896
     [Google Scholar]
  71. RahmanM.I. RipaM. HossanM.S. RahmatullahM. A polyherbal formulation for treatment of anemia, coughs, pain, and loss of appetite.Asian J. Pharmacog.2018222023
     [Google Scholar]
  72. HayatiE.K. Muti’ahR. ChusnaI. Identification of secondary metabolites compounds in n-hexane extract of healing stem (Paederia foetida Linn).ALCHEMY201323290310.18860/al.v0i0.2903
     [Google Scholar]
  73. BoseS. SahaS. GoswamiH. ShanmugamG. SarkarK. Involvement of CCCTC-binding factor in epigenetic regulation of cancer.Mol. Biol. Rep.20235012103831039810.1007/s11033‑023‑08879‑3 37840067
     [Google Scholar]
  74. SutharA.C. ChauhanV.S. KatkarK.V. The chemistry, pharmacologic, and therapeutic applications of Polyalthia longifolia.Pharmacogn. Rev.201047626810.4103/0973‑7847.65329 22228943
     [Google Scholar]
  75. MishraR.O. BishtS.S. Characterization of few medicinal plants from southern Orissa for their free radical scavenging property.Int. J. Pharm. Bio. Sci.201234669675
     [Google Scholar]
  76. JanaJ.C. Use of traditional and underutilized leafy vegetables of sub-himalayan terai region of west bengal.Acta Hortic.2006752571575
     [Google Scholar]
  77. RahmatullahM. HasanA. ParvinW. MoniruzzamanM. KhatunA. KhatunZ. JahanF.I. JahanR. Medicinal plants and formulations used by the Soren clan of the Santal Tribe in Rajshahi district, Bangladesh for treatment of various ailments.Afr. J. Tradit. Complement. Altern. Med.20129335035910.4314/ajtcam.v9i3.8 23983366
     [Google Scholar]
  78. WangL. JiangY. HanT. ZhengC. QinL. phytochemical, pharmacological and clinical profile of Paederia foetida and P. scandens.Nat. Prod. Commun.2014961934578X1400900640
     [Google Scholar]
  79. HabibM.R. Evaluation of analgesic and sedative-anxiolytic potential of Paderia foetida leaf extract.Am. J. Biomed. Sci.20157298104
     [Google Scholar]
  80. DwivediJ. GuptaA. PaliwalS. RawatA.K.S. Validated simultaneous HPTLC analysis of scopoletin and gallic acid in the methanolic fraction of Jatropha glandulifera.J. Planar Chromatogr. Mod. TLC202033545746210.1007/s00764‑020‑00063‑8
     [Google Scholar]
  81. DubeyS. MitraK. DeB.K. MondalA. BishayeeA. Effects of Paederia foetida and its bioactive phytochemical constituent lupeol on hepatic phase i drug metabolism.NPC20171291401140410.1177/1934578X1701200906
     [Google Scholar]
  82. DwivediJ. GuptaA. VermaS. DwivediM. PaliwalS. RawatA.K.S. Validated high-performance thin-layer chromatographic analysis of ursolic acid and β-sitosterol in the methanolic fraction of Paederia foetida L. leaves.J. Planar Chromatogr. Mod. TLC201831537738110.1556/1006.2018.31.5.5
     [Google Scholar]
  83. PradhanN. ParbinS. KausarC. KarS. MawatwalS. DasL. DebM. SenguptaD. DhimanR. PatraS.K. Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.Food Chem. Toxicol.201913016117310.1016/j.fct.2019.05.016 31112703
     [Google Scholar]
  84. KumarV. KaithwasG. AnwarF. RahmanM. PatelD.K. SinghY. VermaA. Effect of variable doses of Paederia foetida L. combat against experimentally-induced systemic and topical inflammation in Wistar rats.Curr. Bioact. Compd.2018141707910.2174/1573407213666161214122912
     [Google Scholar]
  85. HossainN. ChowdhuryM.A. IqbalA.K.M.P. IslamM.S. Sheikh OmarN.Y. SaifullahA.Z.A. Paederia foetida leaves extract as a green corrosion inhibitor for mild steel in hydrochloric acid solution.Curr. Res. Green. Sustain. Chem.2021410019110.1016/j.crgsc.2021.100191
     [Google Scholar]
  86. PouyfungP. KuraeiadS. YimthiangS. KhamphayaT. Long-term oral administration of Paederia foetida decreases cytochrome P450 mRNA expression: The predictive approaches in a rat model.J. Appl. Pharmaceut Sci.20231322128
     [Google Scholar]
  87. ThirupathiM. SrinivasD. RajendarK. RajuD. ReddyK.J. Phytochemical screening of Paederia foetida a rare medicinal plant-A review.J. Atoms and Molecul.20133117
     [Google Scholar]
  88. LiN. ZhouH. ChenX. ChenH. TangH. YaoY. Potential chemoprotective effect of Paederia foetida Linn on benzyo [a] pyrene induced gastric cancer.Lat. Am. J. Pharm.202140834843
     [Google Scholar]
  89. PatelD.K. Paederia foetida Linn.: A potential climbing medicinal herb in central India.Int. J. Environ. Sci. Nat. Resour.20176511812410.19080/IJESNR.2017.06.555699
     [Google Scholar]
  90. TassaB. SahuN. BarmanN. SahuG. Anti-hyperlipidemic and anti-oxidant activities of ethanolic extract of Paederia foetida Leaves (EEPFL) in Albino rats.Sci. Pharm.202321263410.58920/sciphar02010022
     [Google Scholar]
  91. MaheshwariP. An endodermal phellogen in the stem of Paederia foetida Linn.Nature1945156395211611710.1038/156116b0
     [Google Scholar]
  92. PalM.K. DeyY.N. Evaluation of anthelmintic activity of leaves of Paederia foetida.Int. J. Pharma Bio Sci.201121227231
     [Google Scholar]
  93. VicencioM.C. Antibacterial efficacy of leaf extracts of Paederia foetida Linnaeus.J. Chem. Res. Adv.20202115
     [Google Scholar]
  94. FerdousJ. RahmanM.E. SraboniF.S. DuttaA.K. RahmanM.S. AliM.R. SikdarB. KhanA. HasanM.F. Assessment of the hypoglycemic and anti-hemostasis effects of Paederia foetida (L.) in controlling diabetes and thrombophilia combining in vivo and computational analysis.Comput. Biol. Chem.202310710795410.1016/j.compbiolchem.2023.107954 37738820
     [Google Scholar]
  95. MukhrianiM. RifaiY. DjabirY.Y. FawwazM. AlamG. Tyrosinase inhibitory and anti-oxidant activity of Paederia foetida L.Indones. J. Pharm.2023
     [Google Scholar]
  96. BeheraB. BeheraS. JenaP.K. BarikD.P. NaikS.K. Adventitious shoot organogenesis and plant regeneration from internode explants of Paederia foetida L.: A valuable medicinal plant.Biosci. Biotechnol. Res. Asia201714389390010.13005/bbra/2523
     [Google Scholar]
  97. R, A.; Chowdhury, A.; Chowdhury, B. Hepatoprotective activity of paederia foetida in vitro and in vivo studies.J. Evid. Based Med. Healthc.201631873373710.18410/jebmh/2016/166
     [Google Scholar]
  98. ChaityA.S. NasrinT. FerdouseK.J. HaqueM.F. IslamM.A. SikdarB. HasanM.F. Antimicrobial Activity of Kalanchoe blossfeldiana and Paederia foetida plant leaves’ extracts against some selected bacterial strains.Rec. Adv. Biol. Med.202063112141810.18639/RABM.2020.1121418
     [Google Scholar]
  99. HashmiS.S. ShahM. MuhammadW. AhmadA. UllahM.A. NadeemM. AbbasiB.H. Potentials of phyto-fabricated nanoparticles as ecofriendly agents for photocatalytic degradation of toxic dyes and waste water treatment, risk assessment and probable mechanism.J. Indian Chem. Soc.202198410001910.1016/j.jics.2021.100019
     [Google Scholar]
  100. MusS. MaryamF. UtamiY.P. FatimahR. Uji toksisitas subkronis ekstrak etanol daun sembukan (Paederia foetida L.) dengan parameter kadar kreatinin dan bun pada mencit (Mus musculus).Jantan. J. Mandala Pharm. Indonesia20239222122710.35311/jmpi.v9i2.339
     [Google Scholar]
  101. SenapatiM.R. BeheraP.C. BisoiP.C. MaityA. ParijaS.C. HPTLC finger print analysis of phytophenols of Paederia foetida under different extraction regimen.Bioscan201382603609
     [Google Scholar]
  102. DwivediJ. WalP. DashB. OvaisM. SachanP. VermaV. Diabetic pneumopathy-A novel diabetes-associated complication: Pathophysiology, the underlying mechanism and combination medication.Endocrine Metab. Immune Disord. Drug Targ.20242491027105210.2174/0118715303265960230926113201
     [Google Scholar]
  103. MukherjeeA. Purification, characterisation and immobilisation of an acid-stable, raw-starch hydrolysing thiol β-amylase, over produced in the stem of Paederia foetida.Biocatal. Biotransform.202139642944210.1080/10242422.2021.1964484
     [Google Scholar]
  104. GogoiJ.C. MohantaD. BorahP.K. Hepatoprotective activity of Averrhoa carambola, Cajanus cajan and Paederia foetida against acetaminophen and D-galactosamine induced hepatotoxicity in rats.J. Pharm. Res.201092768010.18579/jpcrkc/2010/9/2/79491
     [Google Scholar]
  105. GuptaA. DwivediJ. IrshadS. VermaS. PragyadeepS. DwivediH. RawatA.K. Comparative pharmacognostical evaluation and HPTLC analysis of three different species of bauhinia leaves.Res. J. Pharm. Biol. Chem. Sci.201895347356
     [Google Scholar]
  106. RajashekharaN. SharmaP.P. VasanthP. Comparative study of prasarani [Merremia tridentata Hallier. f.(Convolvulaceae) and Paederia foetida Linn.(Rubiaceae)] in Amavata (rheumatoid arthritis).Ayu2009304503507
     [Google Scholar]
  107. KoleyC. MondalA. DeyS. RawatR. MondalA. RangraN.K. UrolaginD. BeheraP. MohantyD.L. ZafarA. EyupogluV. Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods.Future J. Pharm. Sci.20241016010.1186/s43094‑024‑00633‑1
     [Google Scholar]
  108. ThankhanithikunT. NikomtatJ. The antioxidant properties of skunk vine (Paederia foetida L.) crude extracts and its application in butter cookie.Burapha Sci. J.2023202311101127
     [Google Scholar]
  109. KumarV. PankajkumarS.Y. SinghU. Raj BhattH. ZamanK. AliM.D. Isolation of new racemic sugar (D/L galacturonic acid) from leaves of Paederia foetida Linn.Nat. Preced.20112021575210.1038/npre.2011.5752.1
     [Google Scholar]
  110. BeheraB. BeheraS. Shasmita MohapatraD. BarikD.P. NaikS.K. Regeneration of plants from alginate-encapsulated axenic nodal segments of Paederia foetida L. - A medicinally important and vulnerable plant species.J. Plant Biotechnol.202148425526310.5010/JPB.2021.48.4.255
     [Google Scholar]
  111. MaradaH. PuangsombatP. PromsawanN. Chemical contents and antibacterial activity of volatile oils from Paederia pilifera.J. Essent. Oil-Bear. Plants202427126327110.1080/0972060X.2023.2296997
     [Google Scholar]
  112. NaharL. SarkerS.D. ‘Gandho badali’ (Paederia foetida L.): Horrendous smell, but tremendous medicinal value. Trend.Phytochem. Res.202154166167
     [Google Scholar]
  113. WalP. DwivediJ. WalA. VigH. SinghY. Detailed insight into the pathophysiology and the behavioral complications associated with the Parkinson’s disease and its medications.Future J. Pharm. Sci.2022813310.1186/s43094‑022‑00425‑5
     [Google Scholar]
  114. DwivediJ. SachanP. WalP. DwivediS. SharmaM.C. RaoS.P. Detailed review on phytosomal formulation attenuating new pharmacological therapies.Adv. Tradit. Med.2023202312610.1007/s13596‑023‑00712‑3
     [Google Scholar]
  115. WangW. XuT. SongX. ChenC. LiuD. HanB. YiS. The complete chloroplast genome of the medicinal plant Paederia foetida L.Mitochondrial DNA B Resour.2022771218122010.1080/23802359.2022.2087563 35837498
     [Google Scholar]
  116. WariD. YamashitaJ. KataokaY. KoharaY. HinomotoN. KishimotoH. ToyoshimaS. SonodaS. Population survey of phytoseiid mites and spider mites on peach leaves and wild plants in Japanese peach orchard.Exp. Appl. Acarol.201463331333210.1007/s10493‑014‑9788‑9 24659516
     [Google Scholar]
  117. BhagatM. AnandR. DattR. GuptaV. AryaS. Green synthesis of silver nanoparticles using aqueous extract of Rosa brunonii Lindl and their morphological, biological and photocatalytic characterizations.J. Inorg. Organomet. Polym. Mater.20192931039104710.1007/s10904‑018‑0994‑5
     [Google Scholar]
  118. JhaK.K. Smith-HallC. Three models to illustrate plant-people relationships in the medicinal plant hotspots of North East India.Ethnobot. Res. Appl.20232614810.32859/era.26.7.1‑48
     [Google Scholar]
  119. DwivediJ. SachanP. WalP. A mechanistic approach on structural, analytical and pharmacological potential of beta-sitosterol: A promising nutraceutical.Curr. Nutr. Food Sci.202420893295110.2174/0115734013245468230927042947
     [Google Scholar]
  120. BhuyanB. ChetiaC. An ethnomedicinal study focusing the genus Costus in Assam with emphasis on traditional medicine.J. Med. Plants Stud.201862178188
     [Google Scholar]
  121. DuttaU. DeyS. Bioassay of larvicidal efficacy of selected plant extracts against mosquito larvae Anopheles culicifacies and Aedes aegypti L.Bull. Pure. Appl. Sci. Zool.2023421170189
     [Google Scholar]
  122. Gireesh TripathiK.K. KavithaS. Innovative extraction methods and solvent optimization for Paederia foetida in vitro analysis of antioxidant and neuroprotective properties.Bull. Pure. Appl. Sci. Zool.202426976990
     [Google Scholar]
  123. SavitriL. KasimoE.R. The protective effect of kentut leaf extract (Paederia foetida L.) on gastric histopathology in Escherichia coli-Infected sepsis mice model.Biol. Med. Nat. Prod. Chem.202413122723310.14421/biomedich.2024.131.227‑233
     [Google Scholar]
  124. YUNITAM. Antibacterial activity of Paederia foetida leaves using two different extraction procedures against pathogenic bacteria.Biodiversitas (Surak.)20232411
     [Google Scholar]
/content/journals/cchts/10.2174/0113862073314773241115100620
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Paederia Foetida Linn (Rubiaceae): Chemical Diversity, Phytopharmacological Potential, Quantitative Analysis and Clinical Approaches
Comb Chem High Throughput Screen 28, 3293 (2025); https://doi.org/10.2174/0113862073314773241115100620
/content/journals/cchts/10.2174/0113862073314773241115100620
/content/journals/cchts/10.2174/0113862073314773241115100620
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  • Article Type:     Review Article
Keyword(s): folklore use; P. foetida; pharmacological activity; phytochemicals; phytochemistry; toxicological properties

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