Skip to content
2000
Volume 28, Issue 11
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Aims

This study aims to investigate the effects and mechanism of (MOH), a lianoid shrub with potential therapeutic properties, on Metabolism-Associated Fatty Liver Disease (MAFLD).

Objective

The objective of this study was to construct a MOH-MAFLD network prediction model and explore the effect of MOH on MAFLD and its underlying mechanism .

Methods

Screening of MAFLD targets was performed using the DisGeNET database. Venny database was used to establish the MOH-MAFLD interaction network map, while the STRING database was applied to assess the Protein-Protein Interaction (PPI) network. The central target gene was screened using Gene Ontology (GO) function analysis and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway.

Results

GO function enrichment analysis revealed that MOH affected MAFLD through apoptosis and estrogen-related pathways. KEGG pathway enrichment and PPI network analysis indicated that MOH might mitigate MAFLD by reducing apoptosis and improving lipid metabolism. Additionally, 6 weeks of MOH treatment in rats decreased caspase-3 levels and increased Bcl-2, Estrogen receptor α(Esr1), and JUN proteins, thus ameliorating MAFLD progression.

Conclusion

MOH could delay the progression of MAFLD by affecting estrogen-related pathways, reducing cell stress, and inhibiting apoptosis.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cchts/10.2174/0113862073292973240611055359
2024-06-26
2025-10-15

  • From This Site

    /content/journals/cchts/10.2174/0113862073292973240611055359
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. HanX. CuiZ.Y. SongJ. PiaoH.Q. LianL.H. HouL.S. WangG. ZhengS. DongX.X. NanJ.X. WuY.L. Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver disease via FXR/LXRs-dependent manner.Chem. Biol. Interact.201931110879410.1016/j.cbi.2019.108794 31421115
     [Google Scholar]
  2. GolabiP. RheaL. HenryL. YounossiZ.M. Hepatocellular carcinoma and non-alcoholic fatty liver disease.Hepatol. Int.201913668869410.1007/s12072‑019‑09995‑8 31701393
     [Google Scholar]
  3. Calzadilla BertotL. AdamsL. The natural course of non-alcoholic fatty liver disease.Int. J. Mol. Sci.201617577410.3390/ijms17050774 27213358
     [Google Scholar]
  4. BuzzettiE. PinzaniM. TsochatzisE.A. The multiple-hit pathogenesis of Non-Alcoholic Fatty Liver Disease (NAFLD).Metabolism20166581038104810.1016/j.metabol.2015.12.012 26823198
     [Google Scholar]
  5. KhalafH.M. IbrahimM.A. AminE.F. IbrahimS.A. Abdel-WahabS. FouadY.M. Allopurinol potentiates the hepatoprotective effect of metformin and vitamin E in fructose-induced fatty liver in rats.Clin. Exp. Hepatol.201951657410.5114/ceh.2019.83159 30915409
     [Google Scholar]
  6. ZhangJ. XinH. XuY. ShenY. HeY.Q. Hsien-Yeh; Lin, B.; Song, H.; Juan-Liu; Yang, H.; Qin, L.; Zhang, Q.; Du, J. Morinda officinalis How. – A comprehensive review of traditional uses, phytochemistry and pharmacology.J. Ethnopharmacol.201821323025510.1016/j.jep.2017.10.028 29126988
     [Google Scholar]
  7. LiY.F. GongZ.H. YangM. ZhaoY.M. LuoZ.P. Inhibition of the oligosaccharides extracted from Morinda officinalis, a Chinese traditional herbal medicine, on the corticosterone induced apoptosis in PC12 cells.Life Sci.200372893394210.1016/S0024‑3205(02)02331‑7 12493574
     [Google Scholar]
  8. XiangW. SongQ.S. ZhangH.J. GuoS.P. Antimicrobial anthraquinones from Morinda angustifolia.Fitoterapia2008797-850150410.1016/j.fitote.2008.04.008 18621113
     [Google Scholar]
  9. LongB. XuH. ChenM. ZhangX. HuJ. Effect of Morinda Offieinalis how on free radical metabolism in liver of mice in training.J. Hainan Normal Uni.2012254446448
     [Google Scholar]
  10. HopkinsA.L. Network pharmacology.Nat. Biotechnol.200725101110111110.1038/nbt1007‑1110 17921993
     [Google Scholar]
  11. TangD. Study on pharmacological mechanism of TCM intervention in Type 2 diabetes based on complex network model.Beijing Uni. Chin. Med.2017
     [Google Scholar]
  12. SunW. LiuP. YangB. WangM. WangT. SunW. WangX. ZhengW. SongX. LiJ. A network pharmacology approach: Inhibition of the NF-κB signaling pathway contributes to the NASH preventative effect of an Oroxylum indicum seed extract in oleic acid-stimulated HepG2 cells and high-fat diet-fed rats.Phytomedicine20218815349810.1016/j.phymed.2021.153498 33640247
     [Google Scholar]
  13. RuJ. LiP. WangJ. ZhouW. LiB. HuangC. LiP. GuoZ. TaoW. YangY. XuX. LiY. WangY. YangL. TCMSP: A database of systems pharmacology for drug discovery from herbal medicines.J. Cheminform.2014611310.1186/1758‑2946‑6‑13 24735618
     [Google Scholar]
  14. PanJ. YangH. ZhuL. LouY. JinB. Qingfei Jiedu decoction inhibits PD-L1 expression in lung adenocarcinoma based on network pharmacology analysis, molecular docking and experimental verification.Front. Pharmacol.20221389796610.3389/fphar.2022.897966
     [Google Scholar]
  15. SniderJ. KotlyarM. SaraonP. YaoZ. JurisicaI. StagljarI. Fundamentals of protein interaction network mapping.Mol. Syst. Biol.2015111284810.15252/msb.20156351 26681426
     [Google Scholar]
  16. Escutia-GutiérrezR. Rodríguez-SanabriaJ.S. Monraz-MéndezC.A. García-BañuelosJ. Santos-GarcíaA. Sandoval-RodríguezA. Armendáriz-BorundaJ. Pirfenidone modifies hepatic miRNAs expression in a model of MAFLD/NASH.Sci. Rep.20211111170910.1038/s41598‑021‑91187‑2 34083664
     [Google Scholar]
  17. BoatrightK.M. SalvesenG.S. Mechanisms of caspase activation.Curr. Opin. Cell Biol.200315672573110.1016/j.ceb.2003.10.009 14644197
     [Google Scholar]
  18. RaoG.M.M. RaoC.V. PushpangadanP. ShirwaikarA. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn.J. Ethnopharmacol.2006103348449010.1016/j.jep.2005.08.073 16213120
     [Google Scholar]
  19. GumedeN.M. LembedeB.W. NkomozepiP. BrooksbankR.L. ErlwangerK.H. ChivandiE. β-Sitosterol mitigates the development of high-fructose diet-induced nonalcoholic fatty liver disease in growing male Sprague–Dawley rats.Cancer J. Physiol. Pharmacol.2020981445010.1139/cjpp‑2019‑0295 31560861
     [Google Scholar]
  20. GuicciardiM.E. GoresG.J. Apoptosis: A mechanism of acute and chronic liver injury.Gut20055471024103310.1136/gut.2004.053850 15951554
     [Google Scholar]
  21. XieD. ZhaoH. LuJ. HeF. LiuW. YuW. WangQ. HisatomeI. YamamotoT. KoyamaH. ChengJ. High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling.Am. J. Physiol. Endocrinol. Metab.20213206E1032E104310.1152/ajpendo.00518.2020 33900847
     [Google Scholar]
  22. CzajaM.J. JNK regulation of hepatic manifestations of the metabolic syndrome.Trends Endocrinol. Metab.2010211270771310.1016/j.tem.2010.08.010 20888782
     [Google Scholar]
  23. ShiH. LiC. Research progress on the role of NF-κB and Bcl-2 in apoptosis of hepatocyte in nonalcoholic liver disease.Chongqing Med.2013421618951897
     [Google Scholar]
  24. ChenD.F. WangC.H. [The relationship between the opening of mitochondrial permeability transition pores of cultured hepatocytes with their apoptoses in a non-alcoholic fatty liver disease model].Zhonghua Gan Zang Bing Za Zhi20071511837839 18073067
     [Google Scholar]
  25. TomazL.M. BarbosaM.R. FarahnakZ. LagoeiroC.G. MagossoN.S.S. LavoieJ.M. PerezS.E.A. GLUT2 proteins and PPARγ transcripts levels are increased in liver of ovariectomized rats: Reversal effects of resistance training.J. Exerc. Nutrition Biochem.2016202515710.20463/jenb.2016.06.20.2.7 27508154
     [Google Scholar]
  26. ZhuL. MartinezM.N. EmfingerC.H. PalmisanoB.T. StaffordJ.M. Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity.Am. J. Physiol. Endocrinol. Metab.201430610E1188E119710.1152/ajpendo.00579.2013 24691030
     [Google Scholar]
  27. KurP. Kolasa-WołosiukA. Misiakiewicz-HasK. WiszniewskaB. Sex Hormone-Dependent Physiology and Diseases of Liver.Int. J. Environ. Res. Public Health2020178262010.3390/ijerph17082620 32290381
     [Google Scholar]
/content/journals/cchts/10.2174/0113862073292973240611055359
Loading
Effects and Mechanism of Morinda Officinalis How on Metabolism-Associated Fatty Liver Disease
Comb Chem High Throughput Screen 28, 1861 (2025); https://doi.org/10.2174/0113862073292973240611055359
/content/journals/cchts/10.2174/0113862073292973240611055359
/content/journals/cchts/10.2174/0113862073292973240611055359
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): c-JUN N-terminal kinase; caspase 3; disease; ESR1; fatty liver; Metabolism; Morinda officinalis How

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test