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2000
Volume 28, Issue 5
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Background

Bufei decoction (BFD) is used in clinical practice to treat bronchial asthma (BA), although its molecular mechanism of action remains unclear.

Objective

This study aimed to explore the molecular mechanism of BFD for treating BA.

Methods

Network pharmacology and molecular docking predicted the molecular mechanism and the analysis results were verified using the ELISA kit and RT-qPCR.

Results

There were 58 main active components and 121 potential targets in the BFD from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP), and 11 core targets were obtained from the protein-protein interactions(PPI) network. The gene ontology (GO) analysis found that the treatment of BA with BFD was mainly related to inflammatory reaction, membrane raft, cytokine activity, . The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that it was mainly related to interleukin (IL)-17 signaling pathway, tumor necrosis factor (TNF) signaling pathway, PI3K-Akt signaling pathway, . The molecular docking results showed that the main active ingredients had strong binding ability with core targets. BFD significantly reduced the TNF-α, IL-6, and IL-1β and increased the level of IL-10 in rats with BA. BFD also significantly reduced the mRNA level of PI3K, AKT1, and VEGFA while increasing the mRNA level of TP53 in rats.

Conclusion

This study used network pharmacology methods to predict the potential active ingredients, targets, and pathways of BFD in treating BA and explore its possible molecular mechanism, which provided a theoretical basis for further study.

© 2025 Bentham Science Publishers
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/content/journals/cchts/10.2174/0113862073285566240223144925
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Exploring the Mechanism of Bufei Decoction in the Treatment of Bronchial Asthma Based on Network Pharmacology and Molecular Docking
Comb Chem High Throughput Screen 28, 768 (2025); https://doi.org/10.2174/0113862073285566240223144925
/content/journals/cchts/10.2174/0113862073285566240223144925
/content/journals/cchts/10.2174/0113862073285566240223144925
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  • Article Type:     Research Article
Keyword(s): bronchial asthma; bufei decoction; molecular docking; network pharmacology; pharmacological mechanism; PI3K-Akt signaling pathway

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