Current Cancer Drug Targets - Volume 24, Issue 1, 2024

Lung cancer is one of the most lethal malignancies, with non-small cell lung cancer (NSCLC) being the most common histologic subtype. Metastasis leads to poor prognosis for patients with cancer. Tumor cells leave the tumor lesions, invade the surrounding stroma, and enter the bloodstream as circulating tumor cells (CTCs). The development of CTCs is the beginning of metastasis. The internal environment in which tumor cells gr Read More

Background: Heat shock 70kDa protein 5 (HSPA5), also known as GRP78, is widely expressed in most malignant cells and has been shown to have a significant role in the spread of most malignancies by transferring them to the cell membrane. High-level HSPA5 may serve as an independent prognostic marker for various malignancies due to its ability to accelerate tumor growth and migration, inhibit cell apoptosis and closely Read More

Background: Prostate tumor overexpressed-1 (PTOV1) is a conserved oncogenic adaptor protein associated with cancer progression and may be an independent prognostic marker for several malignancies. Consequently, using pan-cancer research to explore the significance of PTOV1 is valuable, and may reveal novel targets for cancer treatment. Methods: A comprehensive bioinformatics analysis of PTOV1 was perform Read More

Aim: The study aimed to explore the effect of metabolism on lung cancer. Background: The tumor microenvironment is largely influenced by metabolism, tightly involved in tumor progression. Objective: We try to investigate the effect of tumor metabolism terms on non-small cell lung cancer (NSCLC) prognosis, drug and immunotherapy sensitivity, as well as its underlying mechanisms. Methods: All the data was obtaine Read More

Background: Triple-negative breast cancer (TNBC) has the poorest prognosis among all breast cancer subtypes. While several tumor types are excepted to have a curative response to immunotherapy through the AT-rich interaction domain 1A (ARID1A) gene, its role in TNBC remains unclear. Methods: The expression of the ARID1A gene and immune infiltration in TNBC were analyzed by way and function enrichment a Read More

Background: Ubiquitin ligases (E3s) play an important role in multiple cancers. Methods: The open-accessed expression profile and clinical information was downloaded from the TARGET database. The analysis was performed using R software. Results: In this study, we comprehensively investigated the role of E3s in osteosarcomas (OS). We found that among all these E3s, UBR5 is a risk factor for OS. Considering that UB Read More

Background: Necroptosis is correlated with the development, prognosis, and treatment of tumors. However, the function of necroptosis-associated genes (NRGs) in the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC) remains unclear. Methods: In this study, 1210 NSCLC samples were classified into different subtypes based on the expression of 66 NRGs by unsupervised clustering analysis, and further anal Read More

The capacity of cancer cells for abnormal growth and metastasis has made it difficult to find a cure for tumor. Both males and females suffer from lung tumors, and physicians still deem them incurable. The initiation and development of lung tumors can be forced by genomic mutations. Wnt is a critical pathway for regulating growth, differentiation and migration. However, its oncogenic function has been observed in lung cancer. Read More

OSCC (Oral Squamous Cell Carcinoma) is a major health challenge in many parts of the world. It occurs most commonly in males and is associated with tobacco, pan, or areca nut consumption. One of the major challenges associated with the management of OSCC is late diagnosis. As a result, the treatment required is more aggressive, expensive, and has poor prognostic value. On the other hand, early diagnosis of OSCC can b Read More