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2000
Volume 14, Issue 1
  • ISSN: 2211-5447
  • E-ISSN: 2211-5455

Abstract

Introduction

A class of desirable hybrid motifs seen in a number of significant medications includes indoles and coumarins, known as 3-((1H-indol-3-yl)(phenyl)methyl)-4-hydroxy-2H-chromen-2-ones. However, the development of the indole coumarins synthesis technique has many benefits.

Methods

We wish to investigate the significance of 3-((1H-indol-3-yl)(phenyl)methyl)-4-hydroxy-2H-chromen-2-one's molecules and develop a productive method that employs a wider variety of benzaldehydes, 4-hydroxycoumarin, and indoles that react under mild conditions.

Results

As a catalyst, iodine has several advantages over traditional reagents, such as high yields and purity, no toxicity, broad functional group tolerance and simplicity of workup. Molecular iodine has been demonstrated to be a mild, cost-effective and efficient catalyst for the synthesis of 3-((1H-indol-3-yl)(phenyl)methyl)-4-hydroxy-2H-chromen-2-one molecular analogs.

Discussion

Polar protic solvents, such as ethanol, have been found to decrease the synthesis of indole coumarins, and the limited solubility of 4-hydroxycoumarin in nonpolar solvents explains why nonpolar solvents are unwilling to produce biscoumarins and bisindoles.

Conclusion

In conclusion, we discovered a sustainable and effective way to synthesize derivatives of hybrid indole coumarins. Because it employs iodine as a traditional catalyst, it has a clean reaction profile, fast reaction times, and is reasonably priced, the process is truly environmentally friendly.

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Iodine Catalyzed, an Ecofriendly Synthesis of 3-((1H-indol-3-yl) (phenyl)methyl)-4-hydroxy-2H-chromen-2-one’s
Current Catalysis 14, E22115447381679 (2025); https://doi.org/10.2174/0122115447381679250713102708
/content/journals/ccat/10.2174/0122115447381679250713102708
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  • Article Type:     Research Article
Keyword(s): 4-hydroxy coumarin; aldehyde; hybrid indole coumarins; Indole; iodine catalyst; multicomponent reaction

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