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2000
Volume 14, Issue 1
  • ISSN: 2211-5447
  • E-ISSN: 2211-5455

Abstract

Introduction

Many important drugs contain a class of preferred motifs called bisindoles. The development of synthetic approaches for bis(indolyl)methanes (BIMs) offers numerous advantages. However, most methods for synthesizing BIM derivatives require metal catalysts.

Aim

This study aimed to synthesize bisindoles oxidative cleavage of 1,2-diols using periodic. acid.

Methods

For the synthesis of bisindoles oxidative cleavage of 1,2-diols, periodic acid was used. It is a gentle, reasonably priced, and effective testing agent for the synthesis of bisindole analogs from a range of 1,2-diols. Aldehydes were produced by the oxidation of 1,2-diols by periodic acid, and they reacted with indoles to generate a range of bisindoles. The HIO generated from periodic acid accelerated the reaction. The structures of the compounds were confirmed by NMR (1H and 13C), high-resolution mass spectrometry (HRMS), and elemental analysis using a CHNSO analyzer.

Results and Discussion

A variety of BIMs derivatives were produced by oxidatively breaking down 1,2-diols using periodic acid. The appealing aspects of this procedure include its high yield, rapid response time, and catalyst-free conditions.

Conclusion

In this study, a productive and sustainable method for creating BIMs derivatives is presented. The procedure is genuinely green since it uses periodic acid as an oxidizing agent rather than a conventional catalyst, has a clean reaction profile, quick reaction times, and is inexpensive.

© 2025 Bentham Science Publishers
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Synthesis of Bisindoles via Oxidative Cleavage of 1,2-Diols Using Periodic Acid
Current Catalysis 14, E22115447369647 (2025); https://doi.org/10.2174/0122115447369647250526115445
/content/journals/ccat/10.2174/0122115447369647250526115445
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  • Article Type:     Research Article
Keyword(s): 1,2-diol; bisindoles; CHNSO analyzer; conventional catalyst; iodic acid; Oxidizing reagent; periodic acid

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