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2000
Volume 14, Issue 1
  • ISSN: 2211-5501
  • E-ISSN: 2211-551X

Abstract

Introduction

flower aqueous extract is traditionally known for its potential in treating ocular disorders and has been utilized among the local tribal population. In this study, we aimed to evaluate (HC) flower extract for diabetic cataract management using and methods.

Methods

The extract was investigated for phytochemical screening using Fourier Transformed Infrared (FTIR) and Gas Chromatography-Mass Spectrometry (GC/MS) and evaluating total phenolic content, total flavonoid content, antioxidant activity, prediction of drug-likeness activity, and and anti-cataract activity.

Results

The results demonstrated that this plant extract contained significant phenolic compounds and flavonoids, which accelerated the antioxidant activity as estimated in DPPH (IC, 139.67 ± 6.64 µl/mL) and ABTS (IC, 43.87 ± 2.18 µl/mL) assay. GC/MS screened potential compounds, including 4-ethyl-2-methoxyphenol (8.41%), 1-methyl-4-propan-2-ylidenecyclohexene (2.64%), 4-(2-hydroxypropan-2-yl)-1-methylcyclohexan-1-ol (1.9%), Creosol (1.63%), 1h-purin-6-amine, [(2-fluorophenyl) methyl]- (1.45%), Isoborneol (1.36%), (+)-alpha-terpineol (p-menth-1-en-8-ol) (1.24%), Dodec-11-enyl acetate (1.17%), 1, 8-cineol (1.13%), etc. Its therapeutic potential against diabetic cataracts was confirmed through molecular docking with γ-crystallin and aldose reductase inhibitor proteins (1ELP, 1I16, and 4IGS). The ADMET analysis and bioactivity score showed better drug-likeness behavior of identified phytochemicals. results indicated that the flower extract treated group demonstrated a restored reduced glutathione (GSH) level, catalase activity (CAT), and total soluble protein and decreased malondialdehyde (MDA) level in isolated goat lenses, confirming that it could protect from diabetic cataract.

Conclusion

The results indicated that the flower aqueous extract has therapeutic potential for diabetic cataract management and could be further explored for pre-clinical testing.

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Exploring Bioactive Profiling and Anti-cataract Effect of Hedychium coronarium J. Koenig Flower Extract on Glucose-induced Diabetic Cataract Ex vivo Model
Curr. Biotechnol. 14, 29 (2025); https://doi.org/10.2174/0122115501363126250220094448
/content/journals/cbiot/10.2174/0122115501363126250220094448
/content/journals/cbiot/10.2174/0122115501363126250220094448
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  • Article Type:     Research Article
Keyword(s): aldose reductase inhibitor; antioxidant activity; Diabetic cataract; ex vivo study; gas chromatography; Hedychium coronarium

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