Current Bioactive Compounds - Volume 9, Issue 2, 2013

Fungi are far more complex organisms than viruses or bacteria and can develop numerous diseases in plants that cause loss of big portion of the crop every year. Another important aspect is that many filamentous fungi are destructive human pathogens and are thus responsible for enormous diseases in humans. A series of molecules with antifungal activity against different strains of fungi have been found in plants, which are Read More

Enantiomerically pure product synthesis plays a key role in production of pharmaceuticals. The application of biocatalytic approaches represents a convenient and sustainable way for this purpose. The enormous potential of enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity is on increasing awareness. In particular, lipases show a high versatility to recognize non-natural s Read More

The aim of this work is to obtain the bioactive compounds in hydroalcoholic extracts of hawthorn (Crataegus oxyacantha, Fam. Rosaceae), chokeberry (Aronia melanocarpa, Fam. Rosaceae), rosehip (Rosa canina, Fam. Roseaceae) and bilberry (Vaccinium myrtillus L., Fam. Ericaceae) by means of membrane separation process. Fruit extracts were processed by microfiltration at ambient temperature and the bioactive co Read More

Serotonin is a monoamine neurotransmitter and biochemically derived from tryptophan. The present paper examines the in vitro antioxidant and radical scavenging capacity of serotonin using different in vitro methodologies. For the determination of antioxidant activity of serotonin, 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH-) scavenging, 2,2´- azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavengin Read More

Toxoplasma gondii (T. gondii) is the most common cause of secondary central nervous system infection in immunocompromised persons such as AIDS patients. Dihydrofolate reductase and thymidylate synthase enzymes have been studied as attractive targets against parasitic diseases, since they are involved in cell proliferation and influence on DNA synthesis. In this paper, we propose three-dimensional structures of T. gondii Read More

A new and efficient method for the preparation of 3-amino-6-thieno[2,3-b]pyridine-2-carbohydrazides and pyrido[3',2':4,5]thieno[3,2-d]pyramidinones from one-pot synthesis has been accomplished using 3-amino-6-thieno[2,3- b]pyridines with hydrazine hydrate in ethanol under reflux. This new protocol has the advantages of easy availability and high to excellent yields, simple experimental and work-up procedur Read More