Skip to content
2000
Volume 22, Issue 4
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Nanotechnology has emerged as the most active modern research field in the area of science and technology. Various physical, chemical, and biological methods have been used for metal nanoparticle synthesis. Some examples of metal nanoparticles are gold, silver, zinc, and iron nanoparticles, . Physical and chemical methods are costly, require high energy, harsh conditions and toxic chemicals, and generate hazardous compounds. Biological methods using microbes or plant extracts are green processes for the synthesis of nanoparticles. Green synthesis of nanoparticles using plant extracts is a faster, cheaper, eco-friendly bio-catalytic reaction. Plant extracts contain a diverse range of bioactive compounds, including polyphenols, flavonoids, and terpenoids, which possess reducing properties. Iron nanoparticles (INPs), due to their innate and non-toxic properties; have attracted the attention of a lot of researchers. Several researches have been carried out all over the world to explore their role in theranostic, targeted drug delivery, catalysts, antioxidant activity, antimicrobial activity, Magnetic Resonance Imaging (MRI), Magnetic Particle Imaging (MPI), treatment of wastes, degradation of antibiotics and dyes, and remediation of heavy metals and radioactive materials. The present review highlights the biogenic formation of INPs from various plants and summarizes to some degree its role in different applications of the biomedical field. The last section of this review article is dedicated to the summarized perspective on the use of magnetic nanoparticles in medical applications.

© 2026 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cbc/10.2174/0115734072360157250331172042
2025-04-21
2026-03-10

  • From This Site

    /content/journals/cbc/10.2174/0115734072360157250331172042
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. AlbrechtM.A. EvansC.W. RastonC.L. Green chemistry and the health implications of nanoparticles.Green Chem.20068541743210.1039/b517131h
     [Google Scholar]
  2. ZhangF. ChanS.W. SpanierJ.E. ApakE. JinQ. RobinsonR.D. HermanI.P. Cerium oxide nanoparticles: Size-selective formation and structure analysis.Appl. Phys. Lett.200280112712910.1063/1.1430502
     [Google Scholar]
  3. KhanM.F. AnsariA.H. HameedullahM. AhmadE. HusainF.M. ZiaQ. BaigU. ZaheerM.R. AlamM.M. KhanA.M. AlOthmanZ.A. AhmadI. AshrafG.M. AlievG. Sol-gel synthesis of thorn-like ZnO nanoparticles endorsing mechanical stirring effect and their antimicrobial activities: Potential role as nano-antibiotics.Sci. Rep.2016612768910.1038/srep27689 27349836
     [Google Scholar]
  4. SridharaV. AliB. ShaziyaK. SatapathyL.N. KhandelwalP. Biosynthesis and antibacterial activity of silver nanoparticles.Res. J. Biotechnol.2012811117
     [Google Scholar]
  5. DarezereshkiE. Synthesis of maghemite (γ-Fe2O3) nanoparticles by wet chemical method at room temperature.Mater. Lett.201064131471147210.1016/j.matlet.2010.03.064
     [Google Scholar]
  6. AfifiM. AbdelazimA.M. Ameliorative effect of zinc oxide and silver nanoparticles on antioxidant system in the brain of diabetic rats.Asian Pac. J. Trop. Biomed.201551087487710.1016/j.apjtb.2015.06.010
     [Google Scholar]
  7. TreguerM. de CointetC. RemitaH. KhatouriJ. MostafaviM. AmblardJ. BelloniJ. de KeyzerR. Dose rate effects on radiolytic synthesis of gold−silver bimetallic clusters in solution.J. Phys. Chem. B1998102224310432110.1021/jp981467n
     [Google Scholar]
  8. ZhangG. WangD. Fabrication of heterogeneous binary arrays of nanoparticles via colloidal lithography.J. Am. Chem. Soc.2008130175616561710.1021/ja710771j 18384201
     [Google Scholar]
  9. MafunéF. KohnoJ. TakedaY. KondowT. Dissociation and aggregation of gold nanoparticles under laser irradiation.J. Phys. Chem. B2001105389050905610.1021/jp0111620
     [Google Scholar]
  10. ChandrasekaranR. GnanasekarS. SeetharamanP. KeppananR. ArockiaswamyW. SivaperumalS. Formulation of Carica papaya latex-functionalized silver nanoparticles for its improved antibacterial and anticancer applications.J. Mol. Liq.201621923223810.1016/j.molliq.2016.03.038
     [Google Scholar]
  11. ChenW. CaiW. ZhangL. WangG. ZhangL. Sonochemical processes and formation of gold nanoparticles within pores of Mesoporous Silica.J. Colloid Interface Sci.2001238229129510.1006/jcis.2001.7525 11374924
     [Google Scholar]
  12. AgarwalH. Venkat KumarS. RajeshkumarS. A review on green synthesis of zinc oxide nanoparticles: An eco-friendly approach.Resource-Efficient Technol.20173440641310.1016/j.reffit.2017.03.002
     [Google Scholar]
  13. SarataleR.G. SarataleG.D. ShinH.S. JacobJ.M. PugazhendhiA. BhaisareM. KumarG. New insights on the green synthesis of metallic nanoparticles using plant and waste biomaterials: Current knowledge, their agricultural and environmental applications.Environ. Sci. Pollut. Res. Int.20182511101641018310.1007/s11356‑017‑9912‑6 28815433
     [Google Scholar]
  14. PugazhendhiA. BoovaragamoorthyG.M. RanganathanK. NaushadM. KaliannanT. New insight into effective biosorption of lead from aqueous solution using Ralstonia solanacearum: Characterization and mechanism studies.J. Clean. Prod.20181741234123910.1016/j.jclepro.2017.11.061
     [Google Scholar]
  15. HameedA.S.H. KarthikeyanC. AhamedA.P. ThajuddinN. AlharbiN.S. AlharbiS.A. RaviG. In vitro antibacterial activity of ZnO and Nd doped ZnO nanoparticles against ESBL producing Escherichia coli and Klebsiella pneumoniae.Sci. Rep.2016612431210.1038/srep24312 27071382
     [Google Scholar]
  16. LeeS.J. JeongJ.R. ShinS.C. KimJ.C. KimJ.D. Synthesis and characterization of superparamagnetic maghemite nanoparticles prepared by coprecipitation technique.J. Magn. Magn. Mater.200428214715010.1016/j.jmmm.2004.04.035
     [Google Scholar]
  17. MuthukumarH. ChandrasekaranN.I. Naina MohammedS. PichiahS. ManickamM. Iron oxide nano-material: Physicochemical traits and in vitro antibacterial propensity against multidrug resistant bacteria.J. Ind. Eng. Chem.20174512113010.1016/j.jiec.2016.09.014
     [Google Scholar]
  18. KarpagavinayagamP. VedhiC. Green synthesis of iron oxide nanoparticles using Avicennia marina flower extract.Vacuum201916028629210.1016/j.vacuum.2018.11.043
     [Google Scholar]
  19. MohammadT.G. Abd El-RahmanA.F. Environmentally friendly synthesis of silver nanoparticles using Moringa oleifera (Lam) leaf extract and their antibacterial activity against some important pathogenic bacteria.Mycopath201513116
     [Google Scholar]
  20. GovindarajuK. BashaS.K. KumarV.G. SingaraveluG. Silver, gold and bimetallic nanoparticles production using single-cell protein (Spirulina platensis).Geitler. J. Mater. Sci.200843155115512210.1007/s10853‑008‑2745‑4
     [Google Scholar]
  21. NjagiE.C. HuangH. StaffordL. GenuinoH. GalindoH.M. CollinsJ.B. HoagG.E. SuibS.L. Biosynthesis of iron and silver nanoparticles at room temperature using aqueous sorghum bran extracts.Langmuir201127126427110.1021/la103190n 21133391
     [Google Scholar]
  22. MakinoH. EmiH. YamaguchiA. IritaniE. NamikiN. MyojoT. YamamotoK. Environmental and safety issues with nanoparticles. Nanoparticle Technology Handbook.Elsevier200838541710.1016/B978‑044453122‑3.50010‑6
     [Google Scholar]
  23. LiX. ZhaoD. ZhangF. Multifunctional upconversion-magnetic hybrid nanostructured materials: Synthesis and bioapplications.Theranostics20133529230510.7150/thno.5289 23650477
     [Google Scholar]
  24. JeevanandamJ. BarhoumA. ChanY.S. DufresneA. DanquahM.K. Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations.Beilstein J. Nanotechnol.2018911050107410.3762/bjnano.9.98 29719757
     [Google Scholar]
  25. ChavaliM.S. NikolovaM.P. Metal oxide nanoparticles and their applications in nanotechnology.SN Appl. Sci.20191660710.1007/s42452‑019‑0592‑3
     [Google Scholar]
  26. LazarusL.L. RicheC.T. MalmstadtN. BrutcheyR.L. Effect of ionic liquid impurities on the synthesis of silver nanoparticles.Langmuir20122845159871599310.1021/la303617f 23092200
     [Google Scholar]
  27. MigowskiP. MachadoG. TexeiraS.R. AlvesM.C.M. MoraisJ. TraverseA. DupontJ. Synthesis and characterization of nickel nanoparticles dispersed in imidazolium ionic liquids.Phys. Chem. Chem. Phys.20079344814482110.1039/b703979d 17712460
     [Google Scholar]
  28. HuberD.L. Synthesis, properties, and applications of iron nanoparticles.Small20051548250110.1002/smll.200500006 17193474
     [Google Scholar]
  29. PratsinisA. HervellaP. LerouxJ.C. PratsinisS.E. SotiriouG.A. Toxicity of silver nanoparticles in macrophages.Small20139152576258410.1002/smll.201202120 23418027
     [Google Scholar]
  30. RobertsonJ.D. RizzelloL. Avila-OliasM. GaitzschJ. ContiniC. MagońM.S. RenshawS.A. BattagliaG. Purification of nanoparticles by size and shape.Sci. Rep.2016612749410.1038/srep27494 27271538
     [Google Scholar]
  31. SutharJ.K. RokadeR. PratinidiA. KambadkarR. RavindranS. Purification of nanoparticles by liquid chromatography for biomedical and engineering applications.Am. J. Anal. Chem.201781061762410.4236/ajac.2017.810044
     [Google Scholar]
  32. PikulaK. ChaikaV. ZakharenkoA. MarkinaZ. VedyaginA. KuznetsovV. GusevA. ParkS. GolokhvastK. Comparison of the level and mechanisms of toxicity of carbon nanotubes, carbon nanofibers, and silicon nanotubes in bioassay with four marine microalgae.Nanomaterials202010348510.3390/nano10030485 32182662
     [Google Scholar]
  33. DasR. LeoB.F. MurphyF. The toxic truth about carbon nanotubes in water purification: A perspective view.Nanoscale Res. Lett.201813118310.1186/s11671‑018‑2589‑z 29915874
     [Google Scholar]
  34. MukherjeeA. MajumdarS. ServinA.D. PaganoL. DhankherO.P. WhiteJ.C. Carbon nanomaterials in agriculture: A critical review.Front. Plant Sci.2016717210.3389/fpls.2016.00172 26941751
     [Google Scholar]
  35. YangM. ZhangM. Biodegradation of carbon nanotubes by macrophages.Front. Mater.2019622510.3389/fmats.2019.00225
     [Google Scholar]
  36. PattanayakM. NayakP.L. Green synthesis and characterization of zero valent iron nanoparticles from the leaf extract of AzadirachtaIndica (Neem).World J. Nano Sci. Technol.20132169
     [Google Scholar]
  37. SathishkumarG. LogeshwaranV. SarathbabuS. JhaP.K. JeyarajM. RajkuberanC. SenthilkumarN. SivaramakrishnanS. Green synthesis of magnetic Fe3O4 nanoparticles using Couroupita guianensis Aubl.fruit extract for their antibacterial and cytotoxicity activities.Artif. Cells Nanomed. Biotechnol.201846358959810.1080/21691401.2017.1332635 28554257
     [Google Scholar]
  38. FaustJ.J. ZhangW. ChenY. CapcoD.G. Alpha-Fe2O3 elicits diameter-dependent effects during exposure to an in vitro model of the human placenta.Cell Biol. Toxicol.2014301315310.1007/s10565‑013‑9267‑9 24463955
     [Google Scholar]
  39. KanagasubbulakshmiS. KadirveluK. Green synthesis of Iron oxide nanoparticles using Lagenaria siceraria and evaluation of its antimicrobial activity.Def. Life Sci. J.20172442242710.14429/dlsj.2.12277
     [Google Scholar]
  40. YanW. LienH.L. KoelB.E. ZhangW. Iron nanoparticles for environmental clean-up: Recent developments and future outlook.Environ. Sci. Process. Impacts2013151637710.1039/C2EM30691C 24592428
     [Google Scholar]
  41. YangH.M. ParkC.W. ParkS. KimJ.D. Cross-linked magnetic nanoparticles with a biocompatible amide bond for cancer-targeted dual optical/magnetic resonance imaging.Colloids Surf. B Biointerfaces201816118319110.1016/j.colsurfb.2017.10.049 29080502
     [Google Scholar]
  42. ChengF. SuC.H. YangY.S. YehC.S. TsaiC.Y. WuC.L. WuM.T. ShiehD.B. Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications.Biomaterials200526772973810.1016/j.biomaterials.2004.03.016 15350777
     [Google Scholar]
  43. NahaP.C. HsuJ.C. KimJ. ShahS. BouchéM. Si-MohamedS. Rosario-BerriosD.N. DouekP. HajfathalianM. YasiniP. SinghS. RosenM.A. MorganM.A. CormodeD.P. Dextran-coated cerium oxide nanoparticles: A computed tomography contrast agent for imaging the gastrointestinal tract and inflammatory bowel disease.ACS Nano2020148101871019710.1021/acsnano.0c03457 32692538
     [Google Scholar]
  44. Bakhtiari-AslF. DivbandB. MesbahiA. GharehaghajiN. Bimodal magnetic resonance imaging-computed tomography nanoprobes: A review.Nanomed. J.2020711210.22038/nmj.2020.07.01
     [Google Scholar]
  45. HuS. WuX. ZhouB. XuZ. QinJ. LuH. LvL. GaoY. DengL. YinJ. LiG. IMP3 combined with CD44s, a novel predictor for prognosis of patients with hepatocellular carcinoma.J. Cancer Res. Clin. Oncol.2014140688389310.1007/s00432‑014‑1639‑x 24647926
     [Google Scholar]
  46. KimE.H. AhnY. LeeH.S. Biomedical applications of superparamagnetic iron oxide nanoparticles encapsulated within chitosan.J. Alloys Compd.200763363610.1016/j.jallcom.2006.08.311
     [Google Scholar]
  47. HerzS. VogelP. KampfT. DietrichP. VeldhoenS. RückertM.A. KickuthR. BehrV.C. BleyT.A. Magnetic particle imaging–guided stenting.J. Endovasc. Ther.201926451251910.1177/1526602819851202 31131684
     [Google Scholar]
  48. TaleblooN. GudiM. RobertsonN. WangP. Magnetic particle imaging: Current applications in biomedical research.J. Magn. Reson. Imaging20205161659166810.1002/jmri.26875 31332868
     [Google Scholar]
  49. AramiH. TeemanE. TroksaA. BradshawH. SaatchiK. TomitakaA. GambhirS.S. HäfeliU.O. LiggittD. KrishnanK.M. Tomographic magnetic particle imaging of cancer targeted nanoparticles.Nanoscale2017947187231873010.1039/C7NR05502A 29165498
     [Google Scholar]
  50. ZhuX. LiJ. PengP. Hosseini NassabN. SmithB.R. Quantitative drug release monitoring in tumors of living subjects by magnetic particle imaging nanocomposite.Nano Lett.201919106725673310.1021/acs.nanolett.9b01202 31498999
     [Google Scholar]
  51. TewesF. MunnierE. AntoonB. Ngaboni OkassaL. Cohen-JonathanS. MarchaisH. Douziech-EyrollesL. SoucéM. DuboisP. ChourpaI. Comparative study of doxorubicin-loaded poly(lactide-co-glycolide) nanoparticles prepared by single and double emulsion methods.Eur. J. Pharm. Biopharm.200766348849210.1016/j.ejpb.2007.02.016 17433641
     [Google Scholar]
  52. MoghadamtousiS.Z. KadirH.A. HassandarvishP. TajikH. AbubakarS. ZandiK. A review on antibacterial, antiviral, and antifungal activity of curcumin.BioMed Res. Int.20142014186864
     [Google Scholar]
  53. VermaA. StellacciF. Effect of surface properties on nanoparticle-cell interactions.Small201061122110.1002/smll.200901158 19844908
     [Google Scholar]
  54. RoyA. SinghV. SharmaS. AliD. AzadA.K. KumarG. EmranT.B. Antibacterial and dye degradation activity of green synthesized iron nanoparticles.J. Nanomater.202220221363648110.1155/2022/3636481
     [Google Scholar]
  55. NiraimatheeV.A. SubhaV. RavindranR.S.E. RenganathanS. Green synthesis of iron oxide nanoparticles from Mimosa pudica root extract.Int. J. Environ. Sustain. Dev.201615322724010.1504/IJESD.2016.077370
     [Google Scholar]
  56. SubbiahdossG. SharifiS. GrijpmaD.W. LaurentS. van der MeiH.C. MahmoudiM. BusscherH.J. Magnetic targeting of surface-modified superparamagnetic iron oxide nanoparticles yields antibacterial efficacy against biofilms of gentamicin-resistant staphylococci.Acta Biomater.2012862047205510.1016/j.actbio.2012.03.002 22406508
     [Google Scholar]
  57. HajipourM.J. FrommK.M. Akbar AshkarranA. Jimenez de AberasturiD. LarramendiI.R. RojoT. SerpooshanV. ParakW.J. MahmoudiM. Antibacterial properties of nanoparticles.Trends Biotechnol.2012301049951110.1016/j.tibtech.2012.06.004 22884769
     [Google Scholar]
  58. SenthilM. RameshC. Nanoparticles using tridaxprocumbens leaf extract and its antibacterial activity on Pseudomonas aeruginosa.Dig. J. Nanomater. Biostructures201274
     [Google Scholar]
  59. MirzaA.U. KareemA. NamiS.A.A. KhanM.S. RehmanS. BhatS.A. MohammadA. NishatN. Biogenic synthesis of iron oxide nanoparticles using Agrewia optiva and Prunus persica phyto species: Characterization, antibacterial and antioxidant activity.J. Photochem. Photobiol. B201818526227410.1016/j.jphotobiol.2018.06.009 29981488
     [Google Scholar]
  60. YanH. ZhangB. In vitro cytotoxicity of monodispersed hematite nanoparticles on Hek 293 cells.Mater. Lett.201165581581710.1016/j.matlet.2010.12.004
     [Google Scholar]
  61. UrdzíkováL. JendelováP. GlogarováK. BurianM. HájekM. SykováE. Transplantation of bone marrow stem cells as well as mobilization by granulocyte-colony stimulating factor promotes recovery after spinal cord injury in rats.J. Neurotrauma20062391379139110.1089/neu.2006.23.1379 16958589
     [Google Scholar]
  62. TurnovcovaK. RuzickovaK. VanecekV. SykovaE. JendelovaP. Properties and growth of human bone marrow mesenchymal stromal cells cultivated in different media.Cytotherapy200911787488510.3109/14653240903188947 19903100
     [Google Scholar]
  63. PaikS.Y.R. KimJ.S. ShinS. KoS. Characterization, quantification, and determination of the toxicity of iron oxide nanoparticles to the bone marrow cells.Int. J. Mol. Sci.2015169222432225710.3390/ijms160922243 26389886
     [Google Scholar]
  64. NovotnaB. JendelovaP. KapcalovaM. RossnerP.Jr TurnovcovaK. BagryantsevaY. BabicM. HorakD. SykovaE. Oxidative damage to biological macromolecules in human bone marrow mesenchymal stromal cells labeled with various types of iron oxide nanoparticles.Toxicol. Lett.20122101536310.1016/j.toxlet.2012.01.008 22269213
     [Google Scholar]
  65. van BuulG.M. KotekG. WielopolskiP.A. FarrellE. BosP.K. WeinansH. GrohnertA.U. JahrH. VerhaarJ.A.N. KrestinG.P. van OschG.J.V.M. BernsenM.R. Clinically translatable cell tracking and quantification by MRI in cartilage repair using superparamagnetic iron oxides.PLoS One201162e1700110.1371/journal.pone.0017001 21373640
     [Google Scholar]
  66. JendelováP. HerynekV. DeCroosJ. GlogarováK. AnderssonB. HájekM. SykováE. Imaging the fate of implanted bone marrow stromal cells labeled with superparamagnetic nanoparticles.Magn. Reson. Med.200350476777610.1002/mrm.10585 14523963
     [Google Scholar]
  67. JendelováP. HerynekV. UrdzíkováL. GlogarováK. KroupováJ. AnderssonB. BryjaV. BurianM. HájekM. SykováE. Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord.J. Neurosci. Res.200476223224310.1002/jnr.20041 15048921
     [Google Scholar]
  68. GuoJ. ShenJ.K. WangL. XiaoL. ZhangR.J. LuoW.F. GongZ.G. SunJ. XuH. SiroisP. LiK. In vivo evaluation of cerebral transplantation of resovist-labeled bone marrow stromal cells in Parkinson’s disease rats using magnetic resonance imaging.Appl. Biochem. Biotechnol.2011163563664810.1007/s12010‑010‑9069‑y 20821072
     [Google Scholar]
  69. RaduM. MunteanuM.C. PetracheS. SerbanA.I. DinuD. HermeneanA. SimaC. DinischiotuA. Depletion of intracellular glutathione and increased lipid peroxidation mediate cytotoxicity of hematite nanoparticles in MRC-5 cells.Acta Biochim. Pol.201057335536010.18388/abp.2010_2416 20835408
     [Google Scholar]
  70. MohanapriyaV. SakthivelR. PhamN.D.K. ChengC.K. LeH.S. DongT.M.H. Nanotechnology: A ray of hope for heavy metals removal.Chemosphere2023311Pt 113698910.1016/j.chemosphere.2022.136989 36309058
     [Google Scholar]
  71. MohammedL. GomaaH.G. RagabD. ZhuJ. Magnetic nanoparticles for environmental and biomedical applications: A review.Particuology20173011410.1016/j.partic.2016.06.001
     [Google Scholar]
  72. EamegdoolS.S. WeibleM.W.II PhamB.T.T. HawkettB.S. GrieveS.M. Chan-lingT. Ultrasmall superparamagnetic iron oxide nanoparticle prelabelling of human neural precursor cells.Biomaterials201435215549556410.1016/j.biomaterials.2014.03.061 24726535
     [Google Scholar]
  73. KarlssonH.L. GustafssonJ. CronholmP. MöllerL. Size-dependent toxicity of metal oxide particles—A comparison between nano- and micrometer size.Toxicol. Lett.2009188211211810.1016/j.toxlet.2009.03.014 19446243
     [Google Scholar]
  74. DarroudiM. HakimiM. GoodarziE. Kazemi OskueeR. Superparamagnetic iron oxide nanoparticles (SPIONs): Green preparation, characterization and their cytotoxicity effects.Ceram. Int.2014409146411464510.1016/j.ceramint.2014.06.051
     [Google Scholar]
  75. CarreiraC. WalkerL. PaulK. SaundersM. The toxicity, transport and uptake of nanoparticles in the in vitro BeWo b30 placental cell barrier model used within NanoTEST.Nanotoxicology2015916610.3109/17435390.2013.833317
     [Google Scholar]
  76. KebedeA. SinghA.K. RaiP.K. GiriN.K. RaiA.K. WatalG. GholapA.V. Controlled synthesis, characterization, and application of iron oxide nanoparticles for oral delivery of insulin.Lasers Med. Sci.201328257958710.1007/s10103‑012‑1106‑3 22581389
     [Google Scholar]
  77. YanaiA. HäfeliU.O. MetcalfeA.L. SoemaP. AddoL. Gregory-EvansC.Y. PoK. ShanX. MoritzO.L. Gregory-EvansK. Focused magnetic stem cell targeting to the retina using superparamagnetic iron oxide nanoparticles.Cell Transplant.20122161137114810.3727/096368911X627435 22405427
     [Google Scholar]
  78. BrayF. FerlayJ. SoerjomataramI. SiegelR.L. TorreL.A. JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J. Clin.201868639442410.3322/caac.21492 30207593
     [Google Scholar]
  79. YounY.S. BaeY.H. Perspectives on the past, present, and future of cancer nanomedicine.Adv. Drug Deliv. Rev.201813031110.1016/j.addr.2018.05.008 29778902
     [Google Scholar]
  80. ObaidatI.M. NarayanaswamyV. AlaabedS. SambasivamS. Muralee GopiC.V.V. Principles of magnetic hyperthermia: A focus on using multifunctional hybrid magnetic nanoparticles.Magnetochemistry2019546710.3390/magnetochemistry5040067
     [Google Scholar]
  81. PucciC. MartinelliC. CiofaniG. Innovative approaches for cancer treatment: Current perspectives and new challenges.Ecancermedicalscience20191396110.3332/ecancer.2019.961 31537986
     [Google Scholar]
  82. SharmaA. GoyalA.K. RathG. Recent advances in metal nanoparticles in cancer therapy.J. Drug Target.201826861763210.1080/1061186X.2017.1400553 29095640
     [Google Scholar]
  83. SavliwalaS. Chiu-LamA. UnniM. Rivera-RodriguezA. FullerE. SenK. ThreadcraftM. RinaldiC. Magnetic nanoparticles.Nanoparticles for Biomedical Applications.Elsevier202019522110.1016/B978‑0‑12‑816662‑8.00013‑8
     [Google Scholar]
  84. MartínM.J. GentiliC. LassalleV. In vitro biological tests as the first tools to validate magnetic nanotheranostics for colorectal cancer models.ChemMedChem202015121003101710.1002/cmdc.202000119 32365271
     [Google Scholar]
  85. CondeJ. DoriaG. BaptistaP. Noble metal nanoparticles applications in cancer.J. Drug Deliv.2012201211210.1155/2012/751075 22007307
     [Google Scholar]
  86. MartinkovaP. BrtnickyM. KynickyJ. PohankaM. Iron oxide nanoparticles: Innovative tool in cancer diagnosis and therapy.Adv. Healthc. Mater.201875170093210.1002/adhm.201700932 29205944
     [Google Scholar]
  87. FathyM.M. FahmyH.M. BalahA.M.M. MohamedF.F. ElshemeyW.M. Magnetic nanoparticles-loaded liposomes as a novel treatment agent for iron deficiency anemia: In vivo study.Life Sci.201923411678710.1016/j.lfs.2019.116787 31445028
     [Google Scholar]
  88. ArrueboM. VilaboaN. Sáez-GutierrezB. LambeaJ. TresA. ValladaresM. González-FernándezÁ. Assessment of the evolution of cancer treatment therapies.Cancers2011333279333010.3390/cancers3033279 24212956
     [Google Scholar]
  89. SoetaertF. KorangathP. SerantesD. FieringS. IvkovR. Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies.Adv. Drug Deliv. Rev.2020658310.1016/j.addr.2020.06.025 32603814
     [Google Scholar]
  90. van der MeelR. LammersT. HenninkW.E. Cancer nanomedicines: Oversold or underappreciated?Expert Opin. Drug Deliv.20171411510.1080/17425247.2017.1262346 27852113
     [Google Scholar]
  91. DobrovolskaiaM.A. ShurinM. ShvedovaA.A. Current understanding of interactions between nanoparticles and the immune system.Toxicol. Appl. Pharmacol.2016299788910.1016/j.taap.2015.12.022 26739622
     [Google Scholar]
  92. ChoiY.H. HanH.K. Nanomedicines: Current status and future perspectives in aspect of drug delivery and pharmacokinetics.J. Pharm. Investig.2018481436010.1007/s40005‑017‑0370‑4 30546919
     [Google Scholar]
  93. WilsonK. BalaA. SindhuR.K. JeengarM.K. VermaI. SwamiR. DoraC.P. Nanonutraceuticals and their applications. Nanotechnology and Drug Delivery.Jenny Stanford Publishing2024577610
     [Google Scholar]
  94. SinghS.K. LuisiD.L. PakR.H. Antibody-drug conjugates: Design, formulation and physicochemical stability.Pharm. Res.201532113541357110.1007/s11095‑015‑1704‑4 25986175
     [Google Scholar]
  95. FasolatoL. MagroM. CozzaG. SbarraF. MolinariS. NovelliE. VianelloF. VenerandoA. An iron shield to protect epigallocatehin-3-gallate from degradation: Multifunctional self-assembled iron oxide nanocarrier enhances protein kinase CK2 intracellular targeting and inhibition.Pharmaceutics2021138126610.3390/pharmaceutics13081266 34452227
     [Google Scholar]
  96. ŻukM. GawędaW. Majkowska-PilipA. OsialM. WolskiM. BilewiczA. KrysińskiP. Hybrid radiobioconjugated superparamagnetic iron oxide-based nanoparticles for multimodal cancer therapy.Pharmaceutics20211311184310.3390/pharmaceutics13111843 34834258
     [Google Scholar]
  97. HassanA.A. OrabyN.H. El-DahshanE.M.E. AliM.A. Antimicrobial potential of iron oxide nanoparticles in control of some causes of microbial skin affection in cattle.Eur. J. Acad. Essays2015262031
     [Google Scholar]
  98. AmatyaR. KimD. MinK.A. ShinM.C. Iron oxide nanoparticles-loaded hydrogels for effective topical photothermal treatment of skin cancer.J. Pharm. Investig.202252677578510.1007/s40005‑022‑00593‑9
     [Google Scholar]
  99. Khodadadi YazdiM. ZarrintajP. HosseiniamoliH. MashhadzadehA.H. SaebM.R. RamseyJ.D. GanjaliM.R. MozafariM. Zeolites for theranostic applications.J. Mater. Chem. B Mater. Biol. Med.20208285992601210.1039/D0TB00719F 32602516
     [Google Scholar]
  100. BruecklH. ShoshiA. SchrittwieserS. SchmidB. SchneeweissP. MitteramskoglerT. HaslingerM.J. MuehlbergerM. SchotterJ. Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach.Sci. Rep.2021111603910.1038/s41598‑021‑85524‑8 33727602
     [Google Scholar]
  101. MedingerJ. NedyalkovaM. LattuadaM. Solvothermal synthesis combined with design of experiments: Optimization approach for magnetite nanocrystal clusters.Nanomaterials202111236010.3390/nano11020360 33535568
     [Google Scholar]
  102. PetropoulosA.E. SchafferB.K. CheneyM.L. EnochsS. ZimmerC. WeisslederR. MR imaging of neuronal transport in the guinea pig facial nerve: Initial findings.Acta Otolaryngol.1995115451251610.3109/00016489509139358 7572127
     [Google Scholar]
  103. NedyalkovaM. DonkovaB. RomanovaJ. TzvetkovG. MadurgaS. SimeonovV. Iron oxide nanoparticles: In vivo/in vitro biomedical applications and in silico studies.Adv. Colloid Interface Sci.201724919221210.1016/j.cis.2017.05.003 28499604
     [Google Scholar]
  104. CaizerC. CaizerI.S. Study on maximum specific loss power in Fe3O4 nanoparticles decorated with biocompatible gamma-cyclodextrins for cancer therapy with superparamagnetic hyperthermia.Int. J. Mol. Sci.202122181007110.3390/ijms221810071 34576233
     [Google Scholar]
  105. RamzyL. NasrM. MetwallyA.A. AwadG.A.S. Cancer nanotheranostics: A review of the role of conjugated ligands for overexpressed receptors.Eur. J. Pharm. Sci.201710427329210.1016/j.ejps.2017.04.005 28412485
     [Google Scholar]
  106. ToporkiewiczM. MeissnerJ. MatusewiczL. CzogallaA. SikorskiA.F. Toward a magic or imaginary bullet? Ligands for drug targeting to cancer cells: Principles, hopes, and challenges.Int. J. Nanomedicine20151013991414 25733832
     [Google Scholar]
  107. CondeJ. DiasJ.T. GrazúV. MorosM. BaptistaP.V. de la FuenteJ.M. Revisiting 30 years of biofunctionalization and surface chemistry of inorganic nanoparticles for nanomedicine.Front Chem.201424810.3389/fchem.2014.00048 25077142
     [Google Scholar]
  108. NooluB. AjumeeraR. ChauhanA. NagallaB. ManchalaR. IsmailA. BMC complementary and alternative medicine: Murraya koenigii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells.J. Aust. Tradit.-Med. Soc.20131915052
     [Google Scholar]
  109. HuangL. WengX. ChenZ. MegharajM. NaiduR. Synthesis of iron-based nanoparticles using oolong tea extract for the degradation of malachite green.Spectrochim. Acta A Mol. Biomol. Spectrosc.201411780180410.1016/j.saa.2013.09.054 24094918
     [Google Scholar]
  110. Kiruba DanielS.C.G. VinothiniG. SubramanianN. NehruK. SivakumarM. Biosynthesis of Cu, ZVI, and Ag nanoparticles using Dodonaea viscosa extract for antibacterial activity against human pathogens.J. Nanopart. Res.2013151131910.1007/s11051‑012‑1319‑1
     [Google Scholar]
  111. BiruduR.B. NaikJ.M. RevanaS.D. JilaniS.K. JanardhanM. Phytochemical screening of ethanolic extract of Passiflora foetida (Linn) and medicinal importance.Indian J. Res. Pharm. Biotechnol.201534324
     [Google Scholar]
  112. Katata-SeruL. MoremediT. AremuO.S. BahadurI. Green synthesis of iron nanoparticles using Moringa oleifera extracts and their applications: Removal of nitrate from water and antibacterial activity against Escherichia coli.J. Mol. Liq.201825629630410.1016/j.molliq.2017.11.093
     [Google Scholar]
  113. El-KassasH.Y. Aly-EldeenM.A. GharibS.M. Green synthesis of iron oxide (Fe3O4) nanoparticles using two selected brown seaweeds: Characterization and application for lead bioremediation.Acta Oceanol. Sin.2016358899810.1007/s13131‑016‑0880‑3
     [Google Scholar]
  114. KhataeeA. KayanB. KalderisD. KarimiA. AkayS. KonsolakisM. Ultrasound-assisted removal of Acid Red 17 using nanosized Fe3O4-loaded coffee waste hydrochar.Ultrason. Sonochem.201735Pt A728010.1016/j.ultsonch.2016.09.00427637143
     [Google Scholar]
  115. HorstM.F. CoralD.F. Fernández van RaapM.B. AlvarezM. LassalleV. Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments.Mater. Sci. Eng. C20177444345010.1016/j.msec.2016.12.035 28254315
     [Google Scholar]
  116. NahariM.H. Al AliA. AsiriA. MahnashiM.H. ShaikhI.A. ShettarA.K. HoskeriJ. Green synthesis and characterization of iron nanoparticles synthesized from aqueous leaf extract of Vitex leucoxylon and Its biomedical applications.Nanomaterials20221214240410.3390/nano12142404 35889627
     [Google Scholar]
  117. SharmaD. LedwaniL. MehrotraT. KumarN. PervaizN. KumarR. Biosynthesis of hematite nanoparticles using Rheum emodi and their antimicrobial and anticancerous effects in vitro.J. Photochem. Photobiol. B202020611184110.1016/j.jphotobiol.2020.111841 32197209
     [Google Scholar]
  118. DevathaC.P. KJ. PatilM. Effect of green synthesized iron nanoparticles by Azardirachta Indica in different proportions on antibacterial activity.Environ. Nanotechnol. Monit. Manag.20189859410.1016/j.enmm.2017.11.007
     [Google Scholar]
  119. IqbalJ. AbbasiB.A. AhmadR. ShahbazA. ZahraS.A. KanwalS. MunirA. RabbaniA. MahmoodT. Biogenic synthesis of green and cost effective iron nanoparticles and evaluation of their potential biomedical properties.J. Mol. Struct.2020119912697910.1016/j.molstruc.2019.126979
     [Google Scholar]
  120. DwivediS. SiddiquiM.A. FarshoriN.N. AhamedM. MusarratJ. Al-KhedhairyA.A. Synthesis, characterization and toxicological evaluation of iron oxide nanoparticles in human lung alveolar epithelial cells.Colloids Surf. B Biointerfaces201412220921510.1016/j.colsurfb.2014.06.064 25048357
     [Google Scholar]
  121. SaifS. TahirA. ChenY. Green synthesis of iron nanoparticles and their environmental applications and implications.Nanomaterials201661120910.3390/nano6110209 28335338
     [Google Scholar]
  122. BatoolF. IqbalM.S. KhanS.U.D. KhanJ. AhmedB. QadirM.I. Biologically synthesized iron nanoparticles (FeNPs) from Phoenix dactylifera have anti-bacterial activities.Sci. Rep.20211112213210.1038/s41598‑021‑01374‑4 34764312
     [Google Scholar]
/content/journals/cbc/10.2174/0115734072360157250331172042
Loading
Advances in Green Synthesis of Iron Nanoparticles and Theranostic Potentials in Healthcare: A Review
Curr. Bioact. Compd. 22, E15734072360157 (2026); https://doi.org/10.2174/0115734072360157250331172042
/content/journals/cbc/10.2174/0115734072360157250331172042
/content/journals/cbc/10.2174/0115734072360157250331172042
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): anticancer; antimicrobial; green synthesis; Iron nanoparticles; Magnetic Resonance Imaging (MRI); target drug delivery

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test