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2000
Volume 22, Issue 4
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Introduction

Curcumin, one of the main compounds of turmeric (), has been extensively studied for its several bioactivities, notably antibacterial and anti-inflammatory properties. However, the limited bioavailability of curcumin restricts its antibacterial and anti-inflammatory effectiveness. Thus, research on the design and synthesis of new curcumin derivatives is being pursued to enhance the efficacy.

Aim

Our study aims to modify the 1,3-dicarbonyl moiety of curcumin to improve its permanence as an anti-inflammatory and antibacterial mediator.

Methods

Curcumin analogs (C1-C9) were synthesized and characterized by diverse spectroscopic techniques. Furthermore, the synthesized compounds were evaluated for their and anti-inflammatory and antibacterial activities. In addition to this, an workup was carried out against the phospholipase A2 enzyme to confirm its anti-inflammatory profile.

Results and Discussion

The anti-inflammatory study revealed that the curcumin analogs, compounds C1, C3, C6, and C7, showed noteworthy inhibition at the 500 µg/ml concentration. Moreover, both acute and chronic anti-inflammatory activity showed a significant gradual decrease in paw thickness and a significant decrease in the weight of the cotton as compared to the standard drug, diclofenac. Besides, the antibacterial result showed a promising zone of inhibition for the compounds ., C1, C2, C5, C6, and C7 at the concentration of 500 µg/ml, compared to the standard drug Amoxicillin, 250 µg/ml. In addition, the docking study reveals that curcumin analogs under observation, ., C1, C2, C3, C6, and C7, had the highest binding affinity (-27.2249 to -21.1238 kcal/mol) with phospholipase A2 (PDB ID: 3U8I).

Conclusion

In conclusion, the findings of this investigation indicate that synthesized curcumin derivatives are promising candidates for further investigation as therapeutic agents to control inflammatory-associated consequences.

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2026-03-10

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Synthesis, Characterization, and Pharmacological Evaluation of Curcumin Framework Employing a State-of-the-Art Computational Study Addressing Inflammatory Activities
Curr. Bioact. Compd. 22, E15734072358927 (2026); https://doi.org/10.2174/0115734072358927250414054914
/content/journals/cbc/10.2174/0115734072358927250414054914
/content/journals/cbc/10.2174/0115734072358927250414054914
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  • Article Type:     Research Article
Keyword(s): anti-inflammatory; antibacterial; Curcuma longa; curcumin derivatives; molecular docking; phospholipase A2

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