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image of Anti-Alzheimer’s, Anticancer, and Antimicrobial Activities of Transition Metal Complexes of 4-[(E)-(5-chloro-2-hydroxy-3-{(E)-(3-nitrophenyl)
diazenyl}benzylidene)amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one

Abstract

Background

Age-related Alzheimer's disease is a common neurodegenerative disease. The number of Alzheimer's patients worldwide is expected to reach approximately 150 million by 2050. Breast cancer is one of the most common cancers in females, and its prevalence rises each year. Annually, worldwide, almost 500,000 women pass away due to breast cancer. Current treatments for Alzheimer’s disease and cancer aim to stop or slow the progression of the disease. Developing more effective methods of treatment has become a global effort. Many scientists from around the world are busy in finding effective treatment solutions for Alzheimer’s disease and cancer. The metal-ligand chemistry shows a variety of applications, including physiological and pharmacological activities.

Methods

The green and efficient synthesis of coordination complexes of novel azo-Schiff
base ligand 4-[(E)-(5-chloro-2-hydroxy-3-{(E)-(3-nitrophenyl)diazenyl}benzylidene)amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one was performed by grinding technique. Further, metal salts were introduced to this azo-Schiff base ligand, and metal complexes were synthesized. These synthesized products were characterized by 1H-NMR spectra, mass spectra, FTIR spectra, electronic spectra, elemental analysis, thermal analysis, X-ray powder diffraction, molar conductivity, ., and their anti-Alzheimer’s, anticancer, and antimicrobial activities were assessed by MTT assay and disc diffusion method, respectively.

Result

The structures of the azo-Schiff base ligand and its metal complexes were confirmed by using various spectroscopic techniques. In the biological activity study, many complexes showed higher inhibition than the standard reference drug.

Conclusion

The synthesized metal complexes exhibited higher biological activities than the azo-Schiff base ligand. All metal complexes, except for some, served as anti-Alzheimer’s and anticancer agents.

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2025-02-26
2025-03-25

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Anti-Alzheimer’s, Anticancer, and Antimicrobial Activities of Transition Metal Complexes of 4-[(E)-(5-chloro-2-hydroxy-3-{(E)-(3-nitrophenyl)
diazenyl}benzylidene)amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
Bentham Science Publishers ; https://doi.org/10.2174/0115734072349875250224092826
/content/journals/cbc/10.2174/0115734072349875250224092826
/content/journals/cbc/10.2174/0115734072349875250224092826
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  • Article Type:     Research Article
Keywords: MCF-7 ; SHSY-5Y ; inhibition spectra ; grinding technique ; 4-Aminoantipyrine ; bacteria

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