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2000
Volume 21, Issue 8
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

The traditional use of medicinal plants holds a wealth of ancient wisdom that inspires modern research. , generally recognized as betel leaf, is valued in traditional medicine systems across various cultures for its diverse health benefits. The betel leaves have several significant uses as antioxidant, anti-inflammatory, and antiapoptotic activity which help in neuroprotection. Many phytochemicals are present in the betel leaves, including hydroxychavicol, caryophyllene, eugenols, tannins, and polyphenols, which have positive activity on neurological and other cognitive impairments. Some studies have shown that has a cholinergic activity that directly decreases the butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), which are significantly associated with reduced levels of Acetylcholine (Ach) levels in cholinergic dysfunction. This review article delves into the historical significance of traditional medicine and its relevance to contemporary neuropharmacology. By revisiting the age-old wisdom surrounding , we aim to uncover its potential as a valuable source of natural neuropharmacological agents for various neurological conditions.

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2025-12-15

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Piper betle: Ancient Remedies and Modern Neuropharmacological Insights
Curr. Bioact. Compd. 21, E15734072342263 (2025); https://doi.org/10.2174/0115734072342263241115074638
/content/journals/cbc/10.2174/0115734072342263241115074638
/content/journals/cbc/10.2174/0115734072342263241115074638
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  • Article Type:     Review Article
Keyword(s): acetylcholinesterase; Betel leaves; butyrylcholinesterase; neuroprotection; phytochemicals; traditional medicine

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