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2000
Volume 21, Issue 6
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Introduction

Dermatophytes are a class of fungi that invade keratinized tissues in humans and other animals, causing dermatophytoses. The high cost of therapy, side effects of drugs, and occasionally microbial resistance to synthetic drugs are some of the issues that have prompted efforts to find new medicines. This research aimed to study the antifungal properties of ethanolic and methanolic extracts of and plants against and and to ascertain the phenol content of these plants.

Methods

Following the collection and identification of , , and for this descriptive comparative study, they were washed and dried in the shade. Next, the Soxhlet apparatus was used to obtain methanolic and ethanolic extracts from these plants. The antifungal activity of these extracts was examined against and using the diffusion and agar dilution method according to CLSI guidelines. The Minimum Inhibitory Concentration (MIC) and the Minimum Fungicidal Concentration [MFC] of the extracts were also determined compared to griseofulvin. Additionally, the phenol content of these extracts was measured by an optical spectrophotometer.

Results

The methanolic extract of at 200 mg/ml led to the maximum inhibition zones of PTCC 5054, PTCC 5069, and PTCC 5070 that were 23.41, 23.45, and 25.30 mm, respectively. The highest growth rates of , , and in agar dilution method were found in 2.5 mg/ml of ethanolic extract at 19.07, 18.32, and 17.81 mm, respectively. The smallest growth of , , and were observed in the plate containing 40 mg/ml of the methanolic extract of with 5.62, 3.72, and 5.41 mm diameters, respectively. MIC was less than 6.25 mg/ml for methanolic extract of . The tannic acid in the ethanolic and methanolic extracts of and were 227.33 and 482.89 μg/ml, 94 and 475.48 μg/ml, and 27.33 and 60.67 μg/ml, respectively.

Conclusion

The results revealed that methanolic extracts of the plants under study, particularly had a stronger inhibitory impact than ethanolic extracts. Following rigorous toxicity testing and research, methanolic extracts of these plants may prove to be effective options as adjuvants or alternatives to chemical drugs.

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2025-09-03

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Medicinal Plants Antifungal Agents against Pathogenic Dermatophytes and Phenol Content Measurement
Curr. Bioact. Compd. 21, e15734072321198 (2025); https://doi.org/10.2174/0115734072321198240729100051
/content/journals/cbc/10.2174/0115734072321198240729100051
/content/journals/cbc/10.2174/0115734072321198240729100051
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  • Article Type:     Research Article
Keyword(s): antifungal drugs; Dermatophytes; Glycyrrhiza glabra; minimum fungicidal concentration (MFC); minimum inhibitory concentration (MIC); Rumex acetosella; Teucrium polium

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