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2000
Volume 21, Issue 6
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Introduction

As per the literature survey, the pyrimidine-based molecules display prominent antibacterial, anti-inflammatory, antioxidant, anticancer, analgesic, anticonvulsant, anti-tubercular and antimalarial properties. The biological relevance of pyrimidine-based pharmacophore structures encourages us to synthesize some novel imines derived from 2-amino pyrimidine and substituted benzaldehydes.

Objective

The present communication describes the synthesis of six imines derived from 2-aminopyrimidine. The tri-potassium phosphate catalyst used in the current study optimizes the microwave-assisted synthesis of these novel Schiff bases. The reported method for the synthesis of imines is found to be eco-friendly in terms of the effective use of catalyst AlO-KPO with microwave in the synthesis of pyrimidine-based Schiff bases.

Methods

Different spectroscopic methods, such as 1H NMR, IR, GCMS and elemental analysis, were used to determine the structure of all synthesized Schiff bases. Further, the imines were screened for antibacterial properties to check their inhibitory potency against and .

Results

The biological potency of imines was also studied for their antioxidant and anti-inflammatory activity. The obtained results reveal that Schiff base showed potent anti-inflammatory activity with a 31.538% ± 2.055 inhibition of inflammation. Moreover, the synthesized imines have been screened and studied for their antioxidant activity by DPPH and nitric oxide radical scavengers. Some of these, like show potency to scavenge DPPH radicals as compared to standard. In the antimicrobial investigation, most of the Schiff bases showed good inhibitory activity against various tested pathogens. The current study, therefore, contributes to investigate a new class of imines with structurally modified anti-inflammatory and antioxidant drugs.

Conclusion

The outcome of the study revealed that compound showed promising anti-inflammatory activity with inhibition of inflammation. All imines display antibacterial potency in compounds , , and . The antibacterial properties of these imines are attributed to - and as primary bioactive substituents present in the moiety of imines, which enhance inhibitory properties against tested pathogens. The antioxidant scavenging activity of imines indicates that compounds and represent better anti-oxidants as DPPH scavengers than standard ascorbic acid.

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2024-07-03
2025-10-30

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Synthesis, Spectroscopic Characterization and Study of Antibacterial Potency, Antioxidant Scavenging and In-vitro Anti-inflammatory Properties of Pyrimidine-based Schiff Bases
Curr. Bioact. Compd. 21, E030724231542 (2025); https://doi.org/10.2174/0115734072297463240614075754
/content/journals/cbc/10.2174/0115734072297463240614075754
/content/journals/cbc/10.2174/0115734072297463240614075754
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  • Article Type:     Research Article
Keyword(s): anti-inflammatory; Biological relevance; green chemistry; imines; pyrimidine; tri-potassium phosphate

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