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2000
Volume 21, Issue 4
  • ISSN: 1573-4110
  • E-ISSN: 1875-6727

Abstract

Background

It is well-known that essential oils are a rich source of bioactive components and are traditionally used as one of the alternatives to conventional medicines for treating various diseases and symptoms. Like other natural products, they are safe but should be used with care since all substances have potential toxicity depending on the conditions of exposure, the dose, and the route of administration.

Methods

This manuscript studies the chemical composition and antimicrobial properties of essential oil derived from . The essential oil was extracted from fresh fruits using steam distillation and subsequently subjected to Fourier Transform Infrared Spectroscopy (FT-IR) and Gas Chromatography-Mass Spectrometry (GC-MS) analyses. The antimicrobial potential of the essential oil was evaluated against a panel of microorganisms, namely , and .

Results

The GC-MS analysis unveiled a diverse array of compounds within the essential oil, with the notable constituents being linalool, benzyl nitrile, benzene (2-nitroethyl), bicyclo(4.2.0)octa-1,3,5-triene, 1,3,7-Octatrien-5-yne, styrene, butylated hydroxytoluene, and Nerolidol 2. essential oil significantly inhibits the microbial activities of all the tested organisms. It exhibits inhibitory activity against and at a MIC value of 12.5%, and at a MIC value of 25%, at a MIC value of 50%, and at MIC value 25%. The strongest inhibition of the oil is against at a MIC value of 3.12%.

Conclusion

This research posits that the ethnomedicinal value ascribed to the essential oil of can be attributed to the presence of the identified compounds, some of which are already recognized for their biological activities. The essential oil presents promising potential as a source of lead compounds for developing anti-infective drugs, particularly those targeted against .

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2024-07-03
2025-09-30

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References

  1. ObiL.K. OkwuteS.K. Chemical and biological investigations of the leaf extracts of Andrographis paniculata (Acanthaceae).J. Biomed. Res. Environ. Sci.20234335036210.37871/jbres1683
     [Google Scholar]
  2. BakkaliF. AverbeckS. AverbeckD. IdaomarM. Biological effects of essential oils: A review.Food Chem. Toxicol.200846244647510.1016/j.fct.2007.09.106 17996351
     [Google Scholar]
  3. UdouriohG.A. EtokudohM.F. Essential oils and fatty acids composition of dry fruits of tetrapleura tetraptera.J. Appl. Sci. Environ. Manag.20141841942410.4314/jasem.v18i3.8
     [Google Scholar]
  4. ManciantiF. EbaniV.V. Biological activity of essential oils.Molecules202025367810.3390/molecules25030678
     [Google Scholar]
  5. LeherbauerI. StappenI. Selected essential oils and their mechanisms for therapeutic use against public health disorders. An overview.Z. Naturforsch. C J. Biosci.2020757-820522310.1515/znc‑2020‑0007 32623381
     [Google Scholar]
  6. OformaC.C. UdouriohG.A. OjinnakaC.M. Characterization of essential oils and fatty acids composition of stored Ginger (Zingiber officinale Roscoe).J. Appl. Sci. Environ. Manag.202023122231223810.4314/jasem.v23i12.22
     [Google Scholar]
  7. SunW. ShahrajabianM.H. Therapeutic potential of phenolic compounds in medicinal plants-natural health products for human health.Molecules2023284184510.3390/molecules28041845
     [Google Scholar]
  8. Emily ChristieM.F. LanaliceR.F. Antidepressant effects of essential oils: A review of the past decade (2012-2022) and molecular docking study of their major chemical components.Int. J. Mol. Sci.20232411924410.3390/ijms24119244
     [Google Scholar]
  9. MordiJ.C. Ichipi-IfukorP.C. KwekiG.R. Ichipi-IfukorR.N. OyemJ.C. Dennis-EbohU. Preliminary toxicology profile of Dennettia tripetala (Pepper Fruit) methanolic leaves extract.Clin Phytosci202176110.1186/s40816‑021‑00298‑w
     [Google Scholar]
  10. SalawuK. NjokuO.U. OguguaV. SalawuK. NjokuO.U. OguguaV.N. Selected phytochemical, nutritional and anti-nutritional content of fresh ripe fruits of dennettia tripetala and toxicological studies of its alkaloid rich fraction in albino rats.BEST J.2022191121137Available from: https://www.researchgate.net/publication/361197111
    [Google Scholar]
  11. AdesidaS.A. IyebeyeM.I. AinaO.O. PetersR.F. EzeakuC.C. AmosunE.A. Chemical composition and healing potential of essential oil of Dennettia tripetala on methicillin-resistant Staphylococcus aureus: Infected wound model.Beni. Suef Univ. J. Basic Appl. Sci.20221111210.1186/S43088‑022‑00272‑6/FIGURES/6
     [Google Scholar]
  12. OyemitanI.A. IwalewaE.O. AkanmuM.A. OlugbadeT.A. Antinociceptive and antiinflammatory effects of essential oil of Dennettia tripetala G.Baker (Annonaceae) in rodents.Afr. J. Tradit. Complement. Altern. Med.20085435536210.4314/ajtcam.v5i4.31290 20161957
     [Google Scholar]
  13. Dele AkinbulumaM. Tejumade AdepetunM. YeyeE.O. Insecticidal effects of ethanol extracts of capsicum frutescens and dennettia tripetala against sitophilus zeamais motschulsky on stored maize.Int. J. Res. Agricul. Forest.201521117
     [Google Scholar]
  14. MuhammedD. AdebiyiY.H. OdeyB.O. AlawodeR.A. LawalA. OkunlolaB.M. IbrahimJ. BerinyuyE.B. MuhammedD. AdebiyiY.H. OdeyB.O. AlawodeR.A. LawalA. OkunlolaB.M. IbrahimJ. BerinyuyE.B. Dennettia tripetala (Pepper Fruit), a review of its ethno-medicinal use, phytoconstituents, and biological properties.GSC Adv. Res. Rev.2021060303504310.30574/gscarr.2021.6.3.0024
     [Google Scholar]
  15. Philip-AttahT.M. Evaluation of ethanolic extracts of Piper guineense, Dennettia tripetala, and Capsicum frutescens as protectant of smoked fish, Clarias gariepinus (Pisces: Clariidea) against Dermestes maculatus (Coleoptera: Dermestidae).JoBAZ201980710.1186/s41936‑019‑0079‑1
     [Google Scholar]
  16. OluwasinaO.O. EzenwosuI.V. OgidiC.O. OyetayoV.O. Antimicrobial potential of toothpaste formulated from extracts of Syzygium aromaticum, Dennettia tripetala and Jatropha curcas latex against some oral pathogenic microorganisms.AMB Express2019912010.1186/s13568‑019‑0744‑2 30715633
     [Google Scholar]
  17. OyemitanI.A. ElusiyanC.A. AkinkunmiE.O. ObuotorE.M. AkanmuM.A. OlugbadeT.A. Memory enhancing, anticholinesterase and antimicrobial activities of β-phenylnitroethane and essential oil of Dennettia tripetala Baker f.J. Ethnopharmacol.201922925626110.1016/j.jep.2018.10.017 30342196
     [Google Scholar]
  18. AkeemS. JosephJ. KayodeR. KolawoleF. Comparative phytochemical analysis and use of some Nigerian spices. Croat. J. Food.Technol.Biotechnol. Nutrit.201611145151
     [Google Scholar]
  19. AbdallaM.U.E. TaherM. SanadM.I. TadrosL.K. Chemical properties, phenolic profiles and antioxidant activities of pepper fruits.J.Agricul. Chem.Biotechnol.201910713314010.21608/jacb.2019.53475
     [Google Scholar]
  20. BaurF.J. EnsmingerL.G. The association of official analytical chemists (AOAC).J. Am. Oil Chem. Soc.197754417117210.1007/BF02670789
     [Google Scholar]
  21. Sáez-PlazaP. MichałowskiT. NavasM.J. AsueroA.G. WybraniecS. An overview of the kjeldahl method of nitrogen determination. Part I. early history, chemistry of the procedure, and titrimetric finish.Crit. Rev. Anal. Chem.201343417822310.1080/10408347.2012.751786
     [Google Scholar]
  22. da CruzV.H.M. PrioriR.L.G. SantosP.D.S. FerreiraC.S.F. Evaluation of different conventional lipid extraction techniques’ efficiency in obtaining oil from oleaginous seeds.Chem. Pap.20217551552210.1007/s11696‑020‑01324‑w
     [Google Scholar]
  23. StashenkoE.E. JaramilloB.E. MartínezJ.R. Comparison of different extraction methods for the analysis of volatile secondary metabolites of Lippia alba (Mill.) N.E. Brown, grown in Colombia, and evaluation of its in vitro antioxidant activity.J. Chromatogr. A2004102519310310.1016/j.chroma.2003.10.058 14753676
     [Google Scholar]
  24. SowndhararajanK. ChoH. YuB. KimS. Comparison of essential oil compositions of fresh and dried fruits of Magnolia kobus DC.J. Appl. Pharm. Sci.2016614614910.7324/JAPS.2016.60420
     [Google Scholar]
  25. BhatK.G. NalawadeT.M. SogiS. Antimicrobial activity of endodontic medicaments and vehicles using agar well diffusion method on facultative and obligate anaerobes.Int. J. Clin. Pediatr. Dent.20169433534110.5005/jp‑journals‑10005‑1388 28127166
     [Google Scholar]
  26. CheesbroughM. District laboratory practice in tropical countries.2nd edDistrict Laboratory Practice in Tropical Countries2006143410.1017/CBO9780511543470
     [Google Scholar]
  27. JorgensenJ.H. TurnidgeJ.D. Susceptibility test methods: Dilution and disk diffusion methods.Manual of Clinical Microbiology.Wiley Online Library201510.1128/9781555817381.ch71
     [Google Scholar]
  28. HassanL.G. OnwuasoanyaA. KolawoleS.I. CyrilO. Nutritional composition, physicochemical and functional properties of peeled and unpeeled Dennettia tripetala (Pepper fruit).Glob. Scient. J.20197332349Available from: https://www.researchgate.net/publication/338067753
    [Google Scholar]
  29. IhemejeA. OjinnakaM.C. ObiK.C. EkweC.C. Biochemical evaluation of pepper fruit (Dennettia tripetala) and its use as substitute for ginger in Zobo drink production.Acad. Res. Int.20134513521Available from: www.savap.org.pkwww.journals.savap.org.pk
    [Google Scholar]
  30. OkwuD.E. MorahF.N.I. Mineral and nutritive value of Dennettia tripetala fruits.Fruits200459643744210.1051/fruits:2005006
     [Google Scholar]
  31. NdelekwuteE.K. EnyenihiG.E. UnahU.L. MaduH.C. Dietary effects of different organic acids on growth and nutrient digestibility of broiler.Bangladesh J. Anim. Sci.2016452101710.3329/bjas.v45i2.29802
     [Google Scholar]
  32. ElsharifS.A. BanerjeeA. BuettnerA. Structure-odor relationships of linalool, linalyl acetate and their corresponding oxygenated derivatives.Front Chem.201535710.3389/fchem.2015.00057 26501053
     [Google Scholar]
  33. AlaeboP.O. AnumuduG.C. UgwuO.F. AnyadikeN.N. UdensiC.G. IloanusiD.U. DikeV.C. Evaluation of the biochemical and toxicological profile of methanol extract of Dennetti a tripetala (pepper fruit) fresh leaves on some selected parameters in male Albino rats.Anim. Res. Int.20221945714580Available from: www.zoo-unn.org
    [Google Scholar]
  34. Agatonovic-KustrinS. RistivojevicP. GegechkoriV. LitvinovaT.M. MortonD.W. Essential oil quality and purity evaluation via FT-IR spectroscopy and pattern recognition techniques.Appl. Sci.202010729410.3390/app10207294
     [Google Scholar]
  35. MączkaW. Duda-MadejA. GrabarczykM. WińskaK. Natural compounds in the battle against microorganisms-linalool.Molecules20222720692810.3390/molecules27206928
     [Google Scholar]
  36. ZenginH. BaysalA.H. Antibacterial and antioxidant activity of essential oil terpenes against pathogenic and spoilage-forming bacteria and cell structure-activity relationships evaluated by SEM microscopy.Molecules20141911177731779810.3390/molecules191117773
     [Google Scholar]
  37. LiuX. CaiJ. ChenH. ZhongQ. HouY. ChenW. ChenW. Antibacterial activity and mechanism of linalool against Pseudomonas aeruginosa.Microb. Pathog.202014110398010.1016/j.micpath.2020.103980 31962183
     [Google Scholar]
  38. GhoshT. SrivastavaS.K. GauravA. KumarA. KumarP. YadavA.S. PathaniaR. NavaniN.K. A Combination of linalool, vitamin c, and copper synergistically triggers reactive oxygen species and DNA Damage and Inhibits Salmonella enterica subsp. enterica Serovar Typhi and Vibrio fluvialis.Appl. Environ. Microbiol.2019854e02487e1810.1128/AEM.02487‑18 30552187
     [Google Scholar]
  39. PrakashA. VadivelV. RubiniD. NithyanandP. Antibacterial and antibiofilm activities of linalool nanoemulsions against Salmonella Typhimurium.Food Biosci.201928576510.1016/j.fbio.2019.01.018
     [Google Scholar]
  40. ChanW.K. TanL.T.H. ChanK.G. LeeL.H. GohB.H. Nerolidol: A sesquiterpene alcohol with multi-faceted pharmacological and biological activities.Molecules201621552910.3390/molecules21050529
     [Google Scholar]
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Chemical Compositions, Antimicrobial and Therapeutic Properties of Essential Oils of Dennettia tripetala
Current Analytical Chemistry 21, 335 (2025); https://doi.org/10.2174/0115734110313735240624074507
/content/journals/cac/10.2174/0115734110313735240624074507
/content/journals/cac/10.2174/0115734110313735240624074507
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  • Article Type:     Research Article
Keyword(s): biological activities; chemical composition; Dennettia tripetala; essential oils; pepper fruits; therapeutic properties

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