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2000
Volume 21, Issue 5
  • ISSN: 1573-4110
  • E-ISSN: 1875-6727

Abstract

Background

A simple and effective method to separate chlorogenic acid from leaves with macroporous resin was studied in this paper.

Methods

In order to optimize the separation process of chlorogenic acid from leaves, dynamic adsorption and desorption experiments were carried out on a glass column filled with XDA-8 resin. Based on the First-principles calculation, the possible adsorption models were simulated.

Results

Among the six macroporous resins, XDA-8 showed good adsorption/desorption capacity and a high adsorption/desorption ratio for chlorogenic acid. After being treated with XDA-8 resin once, the content of chlorogenic acid from the extraction increased by 525%, and the recovery of chlorogenic acid reached 85.36%.

Conclusion

At 25°C, the adsorption behavior of chlorogenic acid on XDA-8 resin was consistent with the Langmuir isotherm model and pseudo-second-order kinetic model. Furthermore, by calculating the charge changes of the O atom at each position in the chlorogenic acid molecule and the H atom at the adsorption site in polystyrene molecule with resin skeleton, and combining with the electron cloud density distribution diagram of chlorogenic acid and resin skeleton, the adsorption of chlorogenic acid by XDA-8 resin is mainly due to the charge transfer, which causes the electron cloud to overlap.

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2024-09-04
2025-10-03

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Purification and Kinetics of Chlorogenic Acid from Eucommia ulmoides Oliver Leaves by Macroporous Resins Combined with First-principles Calculation
Current Analytical Chemistry 21, 467 (2025); https://doi.org/10.2174/0115734110313275240820100255
/content/journals/cac/10.2174/0115734110313275240820100255
/content/journals/cac/10.2174/0115734110313275240820100255
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  • Article Type:     Research Article
Keyword(s): adsorbent; chlorogenic acid; Eucommia ulmoides; first-principles calculation; macroporous resins; mechanism

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