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2000
Volume 21, Issue 8
  • ISSN: 1573-4110
  • E-ISSN: 1875-6727

Abstract

Background

The transmission of hantaviruses through rodents has been associated with the development of severe illnesses, including Cardiopulmonary Syndrome (CPS) and Hemorrhagic Fever with Renal Syndrome (HFRS). Environmental changes impacting rodent populations affect their global distribution. These are severe diseases, potentially lethal, and widespread, making them a public health issue.

Objective

Computational studies were conducted to better understand the envelope glycoproteins that are expressed by Hantavirus, which produce the cardiopulmonary syndrome and the hemorrhagic fever with renal syndrome.

Methods

The glycoprotein sequences were found through the utilization of specific computational tools, including the Intrinsic Disorder Predisposition (PIDP), Polarity Index Method Profile 3.0v (PIM 3.0v), and genomics software.

Results

Examining the PIM 3.0v profile and the PIDP profile revealed distinct patterns in the envelope glycoproteins of different genotypes of Hantavirus. These patterns allowed for structural and morphological similarities to be identified. In particular, the PIM 3.0v profile shows that it is possible to discriminate between CPS and HFRS groups, and the PIDP profile shows the existence of an overlaid disorder profile of glycoproteins N and C from Hantavirus strains associated with CPS and HFRS.

Conclusion

Using the PIM 3.0v profile, our computer programs were able to identify isolates of Hantavirus envelope glycoproteins associated with cardiopulmonary syndrome and hemorrhagic fever with renal syndrome. We believe this research contributes to a deeper comprehension of these emerging viruses.

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A Bioinformatics Analysis of the Envelope Glycoproteins Expressing the Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever with Renal Syndrome
Current Analytical Chemistry 21, 936 (2025); https://doi.org/10.2174/0115734110297618240703113456
/content/journals/cac/10.2174/0115734110297618240703113456
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  • Article Type:     Research Article
Keyword(s): Cardiopulmonary syndrome; hantavirus envelope glycoproteins; hemorrhagic fever with renal syndrome; intrinsic disorder predisposition; mutant glycoproteins; polarity index method; polarity index method 3.0v profile; structural proteomics

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