Bentham Science Publishers

This book provides an in-depth and comprehensive overview of andrographolides and their analogues, highlighting their botanical origins, phytochemistry, pharmacological properties, and biotechnological applications. It explores the isolation, purification, and spectroscopic characterization of andrographolides from natural sources, emphasizing their therapeutic potential in antidiabetic studies and other medicinal uses. The book also explains cultivation techniques, agronomic strategies for Andrographis species, genetic improvements, and in vivo extraction methods aimed at enhancing andrographolide yields, with a focus on commercial cultivation and export strategies.

Dedicated chapters, contributed by experts, discuss the ethnobotanical significance of Andrographis species, traditional medicinal formulations, and advanced biotechnological interventions for conservation and utilization. Recent breakthroughs in understanding andrographolides'biosynthesis, metabolism, safety aspects, and promising applications in treating diabetes, cancer, inflammation, liver diseases, and neurological disorders are also covered. Readers will gain insight into how andrographolide analogues can be developed as "lead molecules" for creating next-generation phytodrugs.

Key Features

- Provides a comprehensive account of andrographolide-producing plant sources and their phytochemical and pharmacological properties.

- Explores the role of biotechnology in enhancing andrographolide production through in vivo and in vitro methods.

- Highlights the therapeutic efficacy of andrographolides and analogues in antidiabetic, anticancer, hepatoprotective, and anti-inflammatory drug development.

- Discusses cutting-edge advancements in the biosynthesis and semisynthetic derivatives of andrographolides.

- Covers cultivation, agronomic techniques, and genetic improvements to optimize andrographolide production for commercial applications.

This book is a valuable resource for researchers, pharmacologists, biotechnologists, and biomedical professionals focused on natural product-based drug discovery involving andrographolide.

This book provides an updated information about major systems for anesthesia in patients with concomitant diseases. Book chapters are designed to allow anesthesia providers to refresh their knowledge, and be able to focus on the current issues in these subspecialty areas. Readers will be able to approach anesthesia cases more effectively with the information provided. The chapters are written by eminent clinicians who are also outstanding teachers in their respective anesthesia training programs.

Topics covered in this volume include: thoracic anesthesia, cardiac anesthesia, anesthesia in the ENT patient, neuroanesthesia, intensive care / ICU medicine, medical ethics, and interesting cases.

The book serves as a handbook for advanced anesthesia professionals and a textbook for medical students.

Individuals with Angelman Syndrome (AS) present many unique challenges to professionals, parents and others who are committed to maximizing individuals’ competence while ensuring them the best possible quality of life. Angelman Syndrome: Communication, Educational, and Related Considerations is a unique, exhaustive compilation of existing material related to understanding the nature of AS and how individuals’ communication and related skills can be fostered most effectively. It provides readers with a comprehensive understanding of the background of Angelman Syndrome along with an in-depth exploration of communication (with a focus on augmentative and alternative communication), educational, and related issues that should be addressed when attempting to meet the needs of individuals with AS at home, school, work, and elsewhere in the community.

Key features of the book include:

• Extensive background information about medical and related factors behind AS and how they influence individuals’ learning

• A series of prologues written by the parents of individuals with AS

• Contributions from internationally recognized experts on AS, communication disorders, psychology and education

• Numerous practical, evidence-based strategies for conducting assessments and carrying out interventions among AS affected individuals

Speech-language pathologists, allied healthcare providers and educators providing support to affected individuals should benefit from the information provided in the book by being able to identify appropriate communication, behavioral and educational goals. Laypersons, particularly parents, will also find the information highly useful in advocating for best practices for their children (which is partly fostered by the series of parental prologues).

Angelman Syndrome: Communication, Educational, and Related Considerations will not only serve as a valuable reference for improving the learning experience for AS affected individuals but will also embolden both professionals and parents to maintain higher expectations for them.

This reference presents information about models utilized in experimental medicine and pharmaceutical research and development for several human diseases. Written by experts in immunology, cancer biology and pharmacology, the book provides readers with handy notes and updated data on animal models that are critical to research planning and lab execution.

The main feature of the book is a set of 12 structured chapters that focus on a specific disease such as cancer, infectious diseases, autism, autoimmune diseases, Alzheimer's disease and anemia. The contributors have gathered information on a wide range of genetic and physiological animal models that are employed in research with comparative charts that highlight their main differences. The book also includes chapters for special topics like food allergies and dentistry. Additional features of the book are an explanation of disease mechanisms that give an easy understanding, notes for idiopathic models and specific clinical conditions, and a list of references for advanced readers.

Animal Models In Experimental Medicine is essential reading for scholars, graduate students and senior researchers in life sciences and clinical medicine. It also serves as a resource for professionals involved in bench-to-bedside pharmaceutical projects.

Anthocyanins are a diverse group of phytochemicals used for the treatment and management of acute and chronic ailments. This book is a comprehensive guide to anthocyanins and their importance as pharmaceutical and nutraceutical agents. The book provides detailed information about anthocyanin sources and their application in the treatment of diseases including cancer, gastric disorders, infertility, metabolic diseases, and neurological disorders.

Key features

· Explains the importance of phytochemicals and nutraceuticals

· Provides details of anthocyanin sources and mechanisms of action

· Includes chapters dedicated to the use of anthocyanins to treat specific diseases

· Provides a summary of the market for anthocyanins as a pharmaceutical and nutraceutical product

· Includes scientific references

Following the post 9/11 distribution of anthrax spores through the U.S. mail, and the resulting deaths of five individuals - primarily due to initial misdiagnosis - there has been a renewed interest in anthrax among clinicians and intelligence agencies, particularly as a biological warfare agent. This monograph brings forth essential knowledge about anthrax. Included in this volume, are, the early history, non-natural outbreaks of anthrax, characteristics of the causative organism Bacillus anthracis and its relationship to other members of the B. cereus family. Also included are reports on extensive clinical findings, mechanisms of anthrax virulence and the genetics responsible for these virulence factors. The extensive studies over the years regarding the development of veterinary and human vaccines, and molecular studies, including conventional PCR and real-time PCR are explained in comprehensive detail, with the help of tables, figures and extensive references. This eBook serves as an advanced presentation and reference work for individuals seeking detailed information regarding anthrax and as a primary guide for individuals pursuing studies on anthrax.

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides is an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two recent decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

The second volume of this ebook series covers topics including:

-Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis

-Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer

-Anti-Angiogenic Therapy and Cardiovascular Diseases

… and more.

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

This volume brings together 5 reviews on the following topics:

- Retinal angiogenesis

- Effects of brief daily EMF therapy on tumor growths

- Evolution of the role of angiogenesis in cancer treatments over six decades

- Anti-angiogenesis drugs

- Anti-angiogenesis therapy for multiple sclerosis

- Update on the link between angiogenesis and portal hypertension