Bentham Science Publishers

This book represents a novel approach for the trigonometry and an original scientific work in this field, by using the ensemble structure composed of the real analysis and the axiomatic fundaments of geometry. Throughout this e – book one presents, in a proper manner, definitions, properties, formulae and applications more specific of the subject title and its immediate connections. The book is recommended not only as a pertinent introduction for the high school students, being also very useful for the university students, mathematics teachers and anyone who is interested in the major elements regarding the essence of real mathematics.

This update on SARS-CoV-2 focuses on basic knowledge about the virus and COVID-19 treatment. Chapters present basic information about the disease and its treatment. The virology, epidemiology, etiology, and damage response framework of SARS-CoV-2 are also discussed in detail. The book also covers recent topics of interest to pharmacology scholars such as the immunopathogenesis of SARS-CoV2, nanotechnology, repurposed drug treatments, COVID-19 vaccines, and phytomedicine for COVID-19 therapeutics. Readers in pharmacology, virology and medicine will find the book a simple, yet informative update on SARS-CoV-2 and COVID-19 treatment.

All developments in mathematics and computer science facilitate development of industrial applications. This e-book approaches the subject in a profoundly interdisciplinary manner. The spectrum of subjects covered in this e-book includes mathematics, computer science, materials science and industrial applications. Specifically, the e-book elaborates on mathematical models of phase-field transitions. Nonlinear parabolic systems represent the core of this book.

Mathematically speaking, it presents methods related to existence, uniqueness and regularity of solution, fractional steps, analysis of some boundary optimal control problems governed by phase-field transition system, conceptual algorithms to compute the approximate solution and boundary control.

Sample treatment has been the focus of intensive research in the last 20 years since it still remains a bottleneck in precise analytical procedures. The low concentration of the target analytes, the large amount of potential interfering agents and the incompatibility of the sample matrix with the instrumental techniques are the main reasons for these bottlenecks. In most of these methods, sample treatment is an unavoidable step and it has a clear influence on the quality (sensitivity, selectivity, and accuracy) of the final analytical results.

While the usefulness of microextraction techniques has been established, their complete acceptance in analytical laboratories (including official methods of analysis) depends on their successful automation and integration with conventional analytical instrumentation.

Analytical Microextraction Techniques presents comprehensive information about several analytical methods that are useful in the laboratory. These include: sorptive microextraction, solid and liquid phase microextraction, packed sorbent microextraction, miniaturized dispersive solid-phase extraction, thin film and nanoparticle based techniques, and membrane-based techniques.

This is a vital reference on microextraction and sample preparation techniques for applied chemistry students, analytical chemists and laboratory technicians.

Ceramics have been used as biomaterials for oral and maxillofacial applications due to their excellent bioactivity, high hardness and wear resistance. One of the key drawbacks of synthetic implants is their failure to adapt to the local tissue environment. Improvements in reliability and biocompatibility of implants and prostheses can be achieved through surface modifications including the use of biomaterial thin films and nanocoatings.

This book provides readers with information about dental implants and biomaterial fabrication for maxillofacial procedures and dental bone / tissue repair. It is an ideal reference for medical and dental students and professionals (dentists, oral and maxillofacial surgeons, orthopedic surgeons, prosthodontics) who are involved in implantology and tissue engineering. It will also provide valuable insights into the application and production of bioactive materials for any researchers and apprentices in materials science and biomedical engineering.

This book provides an in-depth and comprehensive overview of andrographolides and their analogues, highlighting their botanical origins, phytochemistry, pharmacological properties, and biotechnological applications. It explores the isolation, purification, and spectroscopic characterization of andrographolides from natural sources, emphasizing their therapeutic potential in antidiabetic studies and other medicinal uses. The book also explains cultivation techniques, agronomic strategies for Andrographis species, genetic improvements, and in vivo extraction methods aimed at enhancing andrographolide yields, with a focus on commercial cultivation and export strategies.

Dedicated chapters, contributed by experts, discuss the ethnobotanical significance of Andrographis species, traditional medicinal formulations, and advanced biotechnological interventions for conservation and utilization. Recent breakthroughs in understanding andrographolides'biosynthesis, metabolism, safety aspects, and promising applications in treating diabetes, cancer, inflammation, liver diseases, and neurological disorders are also covered. Readers will gain insight into how andrographolide analogues can be developed as "lead molecules" for creating next-generation phytodrugs.

Key Features

- Provides a comprehensive account of andrographolide-producing plant sources and their phytochemical and pharmacological properties.

- Explores the role of biotechnology in enhancing andrographolide production through in vivo and in vitro methods.

- Highlights the therapeutic efficacy of andrographolides and analogues in antidiabetic, anticancer, hepatoprotective, and anti-inflammatory drug development.

- Discusses cutting-edge advancements in the biosynthesis and semisynthetic derivatives of andrographolides.

- Covers cultivation, agronomic techniques, and genetic improvements to optimize andrographolide production for commercial applications.

This book is a valuable resource for researchers, pharmacologists, biotechnologists, and biomedical professionals focused on natural product-based drug discovery involving andrographolide.

This book provides a quick update on key aspects of current anesthesia practice. Book chapters are written in a concise manner to enable readers (anesthesia providers and medical students) to quickly refresh their knowledge, and understand the essential points about key topics. The chapters are written by eminent clinicians who are also outstanding teachers in their respective anesthesia training programs.

Topics covered in this volume include: trauma, trauma anesthesia, regional anesthesia, upper extremity blocks, lower extremity blocks, ultrasound, the use of ultrasound for blocks and vascular access, coagulation, hemostasis, transfusion, anticoagulants and their reversal, issues in pediatric anesthesia, and pediatric trauma, as well as obstetrical anesthesia.

The book serves as a handbook for advanced anesthesia professionals and a textbook for medical students.

Angiogenesis plays rate limiting roles in tumor growth and invasion. Angiogenesis inhibition has been proposed as a general strategy to fight against cancers. This book covers different therapeutic targets for angiogenesis interventions with emphasis on clinical development of antiangiogenic drugs that target antiangiogenic cascade in different forms of cancers like breast cancer, multiple myeloma, renal carcinoma, gastrointestinal, prostate and lung cancer. Surrogate predictive markers of antiangiogenic therapy in novel preclinical models recapitulating tumor microenvironment together with genomic studies are special features of this book. Gene therapy approaches with emphasis on viral vectors have been explored in preclinical model with direct and indirect angiogenesis inhibitors. Recent advances in clinical application with antiangiogenic therapy resulted in encouraging clinical results are also detailed. It includes chapters that bridge the gap between basic science and clinical application of current knowledge of cancer. Different chapters are contributed by distinguished scientists and clinicians around the world making it an important addition to the bookshelves of clinicians, academics, researchers, students and institutions.

Animal disease models are a vital tool to study diseases and associated conditions. Studies on animal models can, in some cases, be used as a basis for modeling and understanding human diseases. Biomedical scientists face a challenge to choose the correct animal model to study disease pathology, and neurological diseases are no exception to this rule.

Animal Models for Neurological Disorders covers different animal models which have been used for studying neurological disorders. 13 topical chapters have been contributed by a group of experts on the subject with an aim to cover emerging experimental models of a range of neurological diseases encountered in the clinic including Alzheimer’s disease, psychosis, Parkinson’s, Huntington’s disease, vascular dementia, schizophrenia, multiple sclerosis and brain tumors, among others. The chapters also inform readers about relevant clinical correlations in each disease model where appropriate.

Animal Models for Neurological Disorders is intended for all scholarly researchers and students of biomedical sciences, pharmacology, medicine (oncology, neurology, psychiatry), pharmacy, biochemistry, and biotechnology. The organized contents of the book also serve as a quick reference point for scientists working in applied areas of neuroscience including the study of neurodegenerative diseases and cognitive dysfunction in living organisms.

Bentham Briefs in Biomedicine and Pharmacotherapy (Volume 3): Anthraquinones: Bioactive Multifaceted Therapeutic Agents discusses the expansive realm of anthraquinones, pivotal aromatic compounds in medicine, biotechnology, and industry. This comprehensive volume integrates traditional knowledge with cutting-edge research, covering biosynthesis, analytical methodologies, therapeutic applications, and industrial uses.

Key Features:

- Detailed exploration of anthraquinone biosynthesis and bioactivity.

- Advanced insights into nanotechnology-driven drug delivery.

- Modern extraction techniques and analytical methodologies.

- Contributions from leading experts, ensuring rigorous, research-driven content.