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2000
Volume 20, Issue 4
  • ISSN: 1574-8928
  • E-ISSN: 2212-3970

Abstract

Background

Evodiamine (EVO) is an alkaloid extracted from the dried and nearly ripe fruits of and used as an anti-cancer, anti-inflammatory and anti-obesity agent. However, robust evidence of preclinical experiments has been lacking so far. Therefore, the purpose of this article was to investigate the effect of EVO in combination with other treatments on tumors in animal experiments.

Methods

A systematic review and meta-analysis were conducted to assess the anti-tumor effect of evodiamine-combined therapy. The search engine and electronic databases included PubMed, Scopus, China Knowledge Resource Integrated Database (CNKI), and SinoMed. The research method was based on the PRISMA checklist.

Results

A total of 7 studies and 108 animals were included. As a result, EVO combined therapy was found to be more effective than EVO monotherapy. The SMD was -25.64(95% CI: -5.77 -3.13) in tumor growth. In tumor weight, the SMD was -8.91(95% CI: -16.37, -1.44).

Conclusion

EVO has the potential to alleviate the toxicity of chemotherapeutic agents, which increases the translatability to the clinical situation.

© 2025 Bentham Science Publishers
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2025-07-02
2025-12-22

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The Synergistic Anti-tumor Effects of Evodiamine based on Animal Model Experiments: A Systematic Review and Meta-analysis
Recent Patents on Anti-Cancer Drug Discovery 20, 655 (2025); https://doi.org/10.2174/0115748928303602240610063501
/content/journals/pra/10.2174/0115748928303602240610063501
/content/journals/pra/10.2174/0115748928303602240610063501
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Supplements

PRISMA checklist is available as supplementary material on the publisher’s website along with the published article. Supplementary material is available on the publisher’s website along with the published article.

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  • Article Type:     Research Article
Keyword(s): animal model experiment; combined therapy; Euodia rutaec; Evodiamine; meta-analysis; systematic review

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