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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Inhibitory Effects of β-Cyclodextrin and Trehalose on Nanofibril and AGE Formation During Glycation of Human Serum Albumin
- Source: Protein and Peptide Letters, Volume 16, Issue 6, Jun 2009, p. 653 - 659
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- 01 Jun 2009
Abstract
The effects of β-cyclodextrin (β-CyD) and trehalose on glycation of human serum albumin (HSA) were studied. These additives reduced AGEs and nanofibril formation of HSA under in vitro glycation conditions and improved its helical structure. These were accomplished through direct interactions of them with HSA and alterations in solute-protein interactions.
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