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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Reduced NGF Secretion by HT-29 Human Colon Cancer Cells Treated with a GRPR Antagonist
- Source: Protein and Peptide Letters, Volume 16, Issue 6, Jun 2009, p. 650 - 652
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- 01 Jun 2009
Abstract
The gastrin-releasing peptide receptor (GRPR) is a therapeutic target in colon cancer. Here we show that the GRPR antagonist RC-3095 (10-3, 10-6, or 1 μM) decreases nerve growth factor (NGF) secretion measured by enzymelinked immunosorbent assay (ELISA) in HT-29 human colon carcinoma cells. The results suggest that decreased secretion of neurotrophins might be a novel mechanism by which GRPR antagonists exert their antiproliferative effects in cancer cells.
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