Pharmacological Comparison of Two Different Insect Models Using the Scorpion α-Like Toxin BmK M1 from Buthus martensii Karsch

Frank Bosmans; Bert Brone; Yan-Mei Sun; Rong-Huan Zhu; Yu-Mei Xiong; Da-Cheng Wang; Emmy V. Kerkhove; Jan Tytgat

doi:10.2174/0929866053765635

ISSN: 0929-8665
E-ISSN: 1875-5305

Pharmacological Comparison of Two Different Insect Models Using the Scorpion α-Like Toxin BmK M1 from Buthus martensii Karsch
Authors: Frank Bosmans¹, Bert Brone², Yan-Mei Sun³, Rong-Huan Zhu⁴, Yu-Mei Xiong⁵, Da-Cheng Wang⁶, Emmy V. Kerkhove⁷ and Jan Tytgat⁸
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¹ Laboratory of Toxicology, University of Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium. ² Laboratory of Toxicology, University of Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium. ³ Laboratory of Toxicology, University of Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium. ⁴ Laboratory of Toxicology, University of Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium. ⁵ Laboratory of Toxicology, University of Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium. ⁶ Laboratory of Toxicology, University of Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium. ⁷ Laboratory of Toxicology, University of Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium. ⁸ Laboratory of Toxicology, University of Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium.
Source: Protein and Peptide Letters, Volume 12, Issue 4, May 2005, p. 363 - 367
DOI: https://doi.org/10.2174/0929866053765635
- Available online: 01 May 2005

Abstract

In this study, the effect of the scorpion a-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.

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2005-05-01

2025-10-15

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Article Type: Review Article

Keyword(s): bmkm; locust dum neurons; para/tipe; voltage-gated na channels

Pharmacological Comparison of Two Different Insect Models Using the Scorpion α-Like Toxin BmK M1 from Buthus martensii Karsch

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