Vatairea Macrocarpa Lectin Induces Paw Edema With Leukocyte Infiltration.

Nylane M.N. Alencar; Ana M.S. Assreuy; David N. Criddle; Emmanuel P. Souza; Pedro M.G. Soares; Alexandre Havt; Karoline S. Aragao; Daniel P. Bezerra; Ronaldo A. Ribeiro; Benildo S. Cavada

doi:10.2174/0929866043478284

ISSN: 0929-8665
E-ISSN: 1875-5305

Vatairea Macrocarpa Lectin Induces Paw Edema With Leukocyte Infiltration.
Authors: Nylane M.N. Alencar¹, Ana M.S. Assreuy², David N. Criddle³, Emmanuel P. Souza⁴, Pedro M.G. Soares⁵, Alexandre Havt⁶, Karoline S. Aragao⁷, Daniel P. Bezerra⁸, Ronaldo A. Ribeiro⁹ and Benildo S. Cavada¹⁰
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¹ Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. ² Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. ³ Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. ⁴ Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. ⁵ Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. ⁶ Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. ⁷ Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. ⁸ Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. ⁹ Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. ¹⁰ Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil.
Source: Protein and Peptide Letters, Volume 11, Issue 2, Apr 2004, p. 195 - 200
DOI: https://doi.org/10.2174/0929866043478284
- Available online: 01 Apr 2004

Abstract

A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400μg / paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.

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2004-04-01

2025-10-13

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Article Type: Review Article

Keyword(s): leukocyte infiltration; paw edema; Vatairea macrocarpa lectin

Vatairea Macrocarpa Lectin Induces Paw Edema With Leukocyte Infiltration.

Abstract

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