Crystallization and Preliminary X-Ray Crystallographic Analysis of Plasmodium Falciparum S-Adenosyl-L-Homocysteine Hydrolase

S-adenosyl-L-homocysteine hydrolase from a malaria parasite Plasmodium falciparum (PfSAHH) has been crystallized by the vapor diffusion method. The crystals belong to an orthorhombic space group P212121 with the cell dimensions of a = 76.66 Å, b = 86.31 Å, and c = 335.6 Å. There are four subunits (one tetramer) per asymmetric unit. X-ray diffraction data have been collected up to 2.8 Å resolution. Selfrotation function studies suggest that the tetrameric PfSAHH molecule has the 222 point group symmetry.