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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Flexible Crosslinked Benzhydry Support for Gel-Phase Peptide Synthesis
- Source: Protein and Peptide Letters, Volume 9, Issue 2, Apr 2002, p. 167 - 172
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- 01 Apr 2002
Abstract
An amphiphilic support was developed by the suspension polymerization of styrene and 1,4-butanediol dimethacrylate. The copolymer was converted to benzhydryl resin, BDDMA-PS-BH, by a two-step polymer analogous reaction. This resin was employed as a support for the synthesis of delta sleep inducing peptide (DSIP), Trp-Ala-Gly-Gly-Asp-Ala-Ser- Gly-Glu, in high yield and purity by Fmoc / t-Bu tactics.
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