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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Inhibition of Fungal Aldose Reductase
- Source: Protein and Peptide Letters, Volume 8, Issue 5, Oct 2001, p. 407 - 412
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- 01 Oct 2001
Abstract
Aldose reductase (AR) was cloned from the fungal pathogen, Magnaporthe grisea, expressed in Escherichia coli and purified to homogeneity. An experimental fungicide inhibits the M. grisea AR uncompetitively with respect to its aldehyde substrate with a Ki of 130 nM, the potency suggesting that AR is a biochemical target of the fungicide. The M. grisea AR has a high kcat and large differences in substrate specificities.
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