Pharmaceutical Nanotechnology - Online First

Breast cancer poses a formidable challenge due to its inherent difficulty in treatment. Recognizing the imperative need for new therapeutic approaches, this study focuses on a groundbreaking technique that has the potential to reshape breast cancer treatment: siRNA formulations based on lipid nanoparticles (LNPs). This novel method holds promise for transforming the landscape of breast cancer therapy. The primary objective of this research is to conduct a comprehensive assessment of the current state of the art in the field, specifically exploring the potential applications of siRNA treatments encapsulated in LNPs for breast cancer. The research methodology involves a detailed literature review covering breast cancer, siRNA therapy, and lipid nanoparticles. The study investigates the fundamental principles of siRNA therapy, highlighting its capacity to selectively silence genes critical to breast cancer development. Additionally, the application of LNPs in delivering therapeutic siRNA payloads is explored, with an emphasis on the benefits of LNPs, including their biocompatibility and effective siRNA incorporation. Safety and effectiveness characteristics of LNP-based siRNA formulations are also assessed to pave the way for potential therapeutic applications. Findings from the study illuminate the promising characteristics of LNP-siRNA formulations in the treatment of breast cancer. The investigation provides insights into targeting strategies, such as the enhanced permeability and retention (EPR) effect and the utilization of ligand-conjugated nanoparticles. The study outlines potential avenues for therapeutic use, drawing attention to the safety and effectiveness of LNP-based siRNA formulations. In summary, this study aims to reveal intricate interactions between lipid nanoparticle-based siRNA formulations and breast cancer treatment, fostering a transformation in the field by highlighting current developments, future trends, and innovative strategies for next-gen LNP-based siRNA formulations.

Lipid-based nanocarriers have emerged as promising vehicles for the delivery of various therapeutic agents, owing to their biocompatibility, stability, and ability to encapsulate both hydrophilic and hydrophobic drugs. Among these lipid-based nanocarriers, Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) have gained significant attention in the field of drug delivery. This comparative review aims to provide a comprehensive analysis of SLNs and NLCs, focusing on their formulation, physicochemical properties, drug-loading capacity, stability, and drug release profiles. The review highlights the differences in preparation techniques, particle size, zeta potential, drug encapsulation efficiency, stability, drug delivery, cosmetic and personal care, and food industry applications between SLN and NLC. Furthermore, the review discusses the toxicity and safety profiles of these nanoparticles, including cytotoxicity, genotoxicity, acute toxicity, and long-term toxicity. Finally, the review identifies the potential applications, limitations, and future research directions of SLN and NLC.In summary, this comparative review provides valuable insights into the formulation, physicochemical properties, drug-loading capacity, stability, and drug release profiles of SLNs and NLCs. By understanding the similarities and differences between these lipid-based nanocarriers, researchers and pharmaceutical scientists can make informed decisions regarding the selection of the most suitable nanocarrier for specific therapeutic applications.

The exploration of hydrogel materials has gained significant attention due to the ongoing period of collaborative interdisciplinary advancements. Silk fibroin (SF) possesses remarkable attributes, such as less immunogenicity, sterilization efficacy, processability without chemical crosslinkers, excellent biocompatibility, low immunogenicity, non-toxicity, mechanical strength, thermal stability, non-carcinogenicity, and adjustable biodegradability make it a highly valuable biomaterial. Silk fibroin hydrogel (SFH), a versatile biomaterial, has garnered significant attention due to its unique properties. Its biocompatibility, tunable mechanical properties, water retention capacity, and bioactive nature offer a unique combination of features that can effectively promote tissue regeneration and enhance wound healing. The utilization of SF for hydrogel production presents a valuable opportunity to leverage natural resources and promote eco-friendly production practices. With their exceptional properties and versatile applications in biomedicine, silk protein-based hydrogels hold promise for various research fields. This review aims to discuss the potential properties and recent advancements in the application of SF-based hydrogels for preclinical skin wound healing.

Nanoparticles are a significant topic due to their applications in various fields, including biology, optics, catalysis, pharmaceutics, health, agriculture, and industry, with biosynthesis processes being quick, easy, and environmentally friendly. Due to their applications across multiple industries, silver nanoparticles, or AgNPs, have become the most desired nanoparticles with the recent development of nanotechnology. The physical, chemical, and biological characteristics of AgNPs are being studied. These characteristics are crucial for limiting the hazards associated with silver nanoparticles while optimizing their potential applications in many fields. A higher degree of toxicity in both the environment and living things could arise from the increasing use of silver nanoparticles in the product. Silver nanoparticles find application in wound care, anti-infective therapy, food, pharmaceutical, and cosmetic industries. As antioxidant, antiviral, anticancer, antifungal, anti-inflammatory, and microbiological agents, silver nanoparticles are widely used. Not only must the particles be nanoscale in order for silver nanoparticles to be present, but their production must also be simple and inexpensive to achieve. This paper aims to review the different methods of synthesis of silver nanoparticles, properties, characterization, and their applications. In specific, several chemical and green synthesis approaches for synthesising silver nanoparticles have been discussed. The morphology, size, thermal properties, toxicity properties, electrical properties, catalytic properties, and applications of silver nanoparticles are focused. The main focus is on the effective and efficient synthesis of pure silver nanoparticles and their potential applications.

A nanocarrier is a novel colloidal system whose particle size ranges between 1-100 nm. It is extensively utilized in drug delivery and various other sectors, such as the pharmaceutical, food, and dairy industries. The nanocarrier systems, including solid lipid nanoparticles, micelles, liposomes, and other encapsulated compounds, have improved stability, solubility, bioavailability, and quality. Nanocarriers offer therapeutic effectiveness with low toxicity because of their biocompatibility and ability to cross body barriers. Various analytical techniques, such as chromatography and spectroscopy, are crucial in qualitative and quantitative analysis of nanocarrier-based formulations. Molecular identification and drug content determination require chromatographic techniques, particularly HPLC. Spectroscopic techniques such as LC-MS, NMR, GC-MS, CE-MS, Raman, and IR are used to analyze the interaction and molecular structure of the sample. Nanocarriers have several benefits but face various challenges like stability, drug loading, regulatory standards, and biocompatibility. Future surface engineering and nanocarrier design advancements could improve targeted drug delivery and sustained diagnostic applications, significantly impacting healthcare.

The emergence of lipid-based nanoparticulate systems has significantly reshaped the landscape of drug delivery. This review aims to encapsulate the advancements, challenges, and potential of lipid-based nanoparticulate drug delivery in modern therapeutics. Lipid-based nanoparticles, including liposomes, lipid nanoparticles, and solid lipid nanoparticles, harness the biocompatibility and biodegradability of lipids to encapsulate and deliver a diverse range of therapeutic agents. This platform offers solutions to various drug delivery challenges, such as enhancing drug solubility and bio- availability, achieving controlled and sustained release, targeted delivery, and co-delivery of multi-agents. These nanoparticles have demonstrated potential in overcoming biological barriers, including the blood-brain barrier, mucosal barriers, and cellular barriers, enabling the delivery of drugs to previously inaccessible sites. Biocompatibility and reduced toxicity are intrinsic attributes of lipid-based nanoparticles, minimizing immune responses and systemic toxicity while promoting personalized medicine possibilities. However, challenges in formulation, stability, and regulatory approval underscore the need for ongoing research and innovation in this field.

The infusion of nanotechnology into cosmetic formulations marks a transformative shift in beauty science. Although Raymond Reed originally used the word “cosmeceutical,” Dr. Albert Kligman popularised the idea in the late 1970s. Cosmetic Nano Wonders are redefining skincare by leveraging nanomaterials to enhance the stability, delivery, and efficacy of active ingredients. The paradigm shift holds promise for overcoming longstanding challenges in traditional cosmetic formulations. This article aims to explore and showcase the revolutionary impact of nanotechnology on the cosmetic industry. Focusing on key nanocarriers, such as liposomes and nanoparticles, our objective is to illuminate how nanotechnology elevates the performance of beauty products, providing advanced solutions for skincare concerns. This revolution promotes sustainability through green synthesis techniques and enables more accurate and effective therapies for a variety of skin issues, including acne and ageing that raises the bar for safety and innovation in the cosmetics business by enhancing product performance and environmental impact. Conducting a thorough literature review, we analyze recent scientific studies and industry reports to unveil the mechanisms and applications of nanotechnology in cosmetics. Special attention is given to the role of nanocarriers in stability enhancement, targeted delivery, and controlled release, unraveling the methods that drive the transformative potential of Cosmetic Nano Wonders. The database sources are Scopus, PubMed, Google Scholar, and Google Patents. The examination of recent research underscores the tangible benefits of nanotechnology in cosmetics. Cosmetic Nano Wonders demonstrate superior stability, enhanced penetration into skin layers, and controlled release mechanisms, showcasing their potential to revolutionize beauty science and address longstanding challenges in skincare. Cosmetic Nano Wonders represent a groundbreaking shift in beauty science, offering unprecedented possibilities for formulators and consumers. As nanotechnology continues to reshape cosmetic formulations, the future holds the promise of safer, more effective, and personalized skincare solutions, ushering in a new era in beauty science.