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2000
Volume 12, Issue 1
  • ISSN: 2211-7385
  • E-ISSN: 2211-7393
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Abstract

Mahkota Dewa () seed has various phytochemical compounds and low pharmacological activities, including antioxidant and anti-inflammatory activities.

This research aimed to study nanoemulsion preparations of Mahkota Dewa seed (NE-BMD) for their anti-oxidant and anti-inflammatory properties.

The nanoemulsion was prepared using an ultrasonication probe and followed by selecting two formulations, F7 and F8. The anti-oxidant activity test was carried out using the DPPH method, meanwhile, the anti-inflammatory activity test was conducted using the protein denaturation method with Bovine Serum Albumin (BSA) for studies. In addition, for studies, the plethysmometer method was used with 1% carrageenan as an inducer.

The characterization of NE-BMD preparations showed that the particle size and polydispersity index were 26,83 ± 1,27 nm (PI: 0.36 ± 0.03) and 30.73 ± 1.50 nm (PI: 0.32 ± 0.06) for NE-BMD F7 and F8 formulation, respectively. In addition, the anti-oxidant activity test revealed that the IC values of NE_BMD F7 and F8 were 15.62 ± 1.40 µg/ml and 28.39 ± 4.69 µg/ml, respectively. The protein denaturation test showed that the IC values for NE-BMD F7 and F8 were 94.39 ± 1.24 µg/ml and 196.63 ± 1.61 µg/ml, respectively. Meanwhile, the study of anti-inflammatory for NE-BMD F7 with a 1 g/kg BW dose showed a significant improvement in anti-inflammatory activity compared to BMD extract.

This research suggests that due to the smaller drug particle size, the nanoemulsion dosage form of Mahkota Dewa seed extract has anti-oxidant and anti-inflammatory activities, thus emerging as an adjunct alternative treatment for inflammation.

© 2024 The Author(s). Published by Bentham Science Publisher. 
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2024-02-01
2025-09-24

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Improvement in Pharmacological Activity of Mahkota Dewa (Phaleria macrocarpa (Schef. Boerl)) Seed Extracts in Nanoemulsion Dosage Form: In vitro and In vivo Studies
Pharm. Nanotechnol. 12, 90 (2024); https://doi.org/10.2174/2211738511666230602100045
/content/journals/pnt/10.2174/2211738511666230602100045
/content/journals/pnt/10.2174/2211738511666230602100045
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  • Article Type:     Research Article
Keyword(s): anti-inflammatory; anti-oxidant; inflammation; Mahkota Dewa seed; nanoemulsion; plethysmometer method

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