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image of Nano-Pickering Emulsion using Solid Particles of Typhonium flagelliforme Extract as a Stabilizer: Optimization using Response Surface Methodology and Elucidation of Antioxidant and Antibacterial Activities

Abstract

Background

(TF) is a plant known for its high polyphenol content, making it a good option for stabilizing nano-Pickering emulsion systems. Nano-Pickering emulsions use solid particles for better stability and functional properties than conventional ones.

Objective

This study aimed to develop a nano-Pickering emulsion stabilized by TF particles using the Response Surface Methodology (RSM).

Methods

The RSM was used to determine the best formulation and manufacturing process for TF-based nano-Pickering emulsion (TFNPE). The optimal formula was tested for physical stability, antioxidant activity, and antibacterial activity using the agar diffusion method against several bacteria.

Results

The droplet size and distribution of TFNPE were affected by solid particle content, chitosan concentration, and sonication intensity. The optimal formula had 1.84% solid particles, 0.26% chitosan, and 50% sonication intensity. TFNPE remained stable at 4 ± 2°C for six months and showed increased antioxidant capacity (204.76 ± 3.57 mg AEAC/g) relative to TF extract (176.65 ± 2.86 mg AEAC/g). TFNPE also exhibited antibacterial activity against , , and , with inhibition zones of 12.9 ± 0.5 mm, 14.81 ± 0.1 mm and 16.27 ± 0.3 mm, respectively.

Conclusion

The experimental results were well fitted with the selected statistical model. These findings confirmed TFE's ability to act as a stabilizer for Pickering emulsions and determined its significant anti-acne potential due to its antioxidant and antibacterial properties.

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2025-05-22
2025-09-01

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/content/journals/pnt/10.2174/0122117385368118250217051038
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Nano-Pickering Emulsion using Solid Particles of Typhonium flagelliforme Extract as a Stabilizer: Optimization using Response Surface Methodology and Elucidation of Antioxidant and Antibacterial Activities
Bentham Science Publishers ; https://doi.org/10.2174/0122117385368118250217051038
/content/journals/pnt/10.2174/0122117385368118250217051038
/content/journals/pnt/10.2174/0122117385368118250217051038
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  • Article Type:     Research Article
Keywords: anti-acne ; Response Surface Methodology ; Nano-Pickering emulsion ; antibacterial ; antioxidant ; Typhonium flagelliforme

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