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Abstract

Background

This study aimed to develop and optimize a cilostazol-loaded nanomicelle transdermal patch to enhance solubility, stability, and controlled drug release.

Objective

To improve cilostazol bioavailability by formulating a stable, nanomicelle-loaded transdermal patch.

Methods

Nanomicelles were prepared using the thin-film hydration method with Soluplus and Poloxamer 188 as the polymer and surfactant. The transdermal patch was fabricated using the solvent casting method and evaluated for tensile strength, folding endurance, and drug diffusion.

Results

The optimized formulation showed 97.71% entrapment efficiency, 48.86% drug loading, a particle size of 129.07 nm, and a zeta potential of −21.5 mV. The patch exhibited a tensile strength of 141.83 MPa, folding endurance of over 300 folds, and sustained drug diffusion.

Conclusion

The developed transdermal patch offers a promising strategy to enhance cilostazol bioavailability by bypassing first-pass metabolism, promoting better penetration, and ensuring improved patient compliance.

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2025-07-16
2025-11-04

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/content/journals/pnt/10.2174/0122117385362916250630053000
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Development and Optimization of a Cilostazol-Loaded Nanomicelle Transdermal Patch for Hypertension Management
Bentham Science Publishers ; https://doi.org/10.2174/0122117385362916250630053000
/content/journals/pnt/10.2174/0122117385362916250630053000
/content/journals/pnt/10.2174/0122117385362916250630053000
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  • Article Type:     Research Article
Keywords: film forming polymer ; transdermal patch ; Nanomicelles ; cilostazol ; poloxamer 188 ; soluplus

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