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2000
Volume 16, Issue 1
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

L., also known as “Adhomukhi or Gojihva” in Hindi or Sanskrit. It is native to tropical and subtropical Asia and grows in grasslands, wastelands, at forest boundaries. Due to its therapeutic properties, the plant has been traditionally used worldwide as a curative measure for treating various disorders, including menstrual disorders (amenorrhea, dysmenorrhea), respiratory problems (asthma, bronchitis), cancer, heart issues, leukorrhea, and others. It has also been reported to possess various pharmacological properties such as anti-cancerous, anti-diabetic, anti-inflammatory, anti-microbial, anti-oxidant, analgesic, and emmenagogue properties. The entire plant is used medicinally, and due to the presence of anti-cancerous and anti-oxidant activity, it may be a ray of hope for combating the pre and post-menopausal consequences. Herbal drugs are currently in high demand, and their acceptance is growing each passing day due to their efficacy, lack of adverse effects, and low cost. The active phytochemical components found in the roots of L. must first be investigated to justify their therapeutic application in herbal preparations for human use. This review describes L. conventional medicinal uses and presents information on its chemical constituents as well as its pharmacological activity. It also offers plausible hypotheses and mechanistic insights into various phytochemicals, specifically deoxyelephantopin, triterpenoid lupeol, δ- truxinate, elescabertopin A & B, epifriedelinol, germacranolide sesquiterpene lactones, stigmasterol alone or in group and extracts, which might be the reason behind the curative perspective for the treatment of alarming complications, including the treatment for menopausal problems and its consequences such as osteoporosis, cardiovascular diseases, cognition, and breast cancer.

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References

  1. IlankoonI.M.P.S. SamarasingheK. ElgánC. Menopause is a natural stage of aging: A qualitative study.BMC Womens Health20212114710.1186/s12905‑020‑01164‑6 33522914
     [Google Scholar]
  2. GanithaG. PremalathaP.B. KannanI. A study of the age of menopause and menopausal symptoms among women in a rural area of Tamil Nadu, India.J. SAFOMS201752879110.5005/jp‑journals‑10032‑1113
     [Google Scholar]
  3. Menopause2022Available from: https://www.who.int/news-room/fact-sheets/detail/menopause#:~:text=Most%20women%20experience%20menopause%20between,changes%20in%20the%20menstrual%20cycle
  4. AfshariF. BahriN. SajjadiM. MansoorianM. TohidinikH. Menopause uncertainty: The impact of two educational interventions among women during menopausal transition and beyond.Prz. Menopauzanly2020191182410.5114/pm.2020.95305 32508552
     [Google Scholar]
  5. ZamaniyanM. MoosazadehM. PeyvandiS. JaefariK. GoudarziR. MoradinazarM. KheradmandM. Age of natural menopause and related factors among the tabari cohort.J. Menopausal Med.2020261182310.6118/jmm.19004 32307946
     [Google Scholar]
  6. CeylanB. ÖzerdoğanN. Factors affecting age of onset of menopause and determination of quality of life in menopause.J. Turk Soc. Obstet. Gynecol.2015121434910.4274/tjod.79836 28913040
     [Google Scholar]
  7. PeacockK. CarlsonK. KetvertisK.M. Menopause.Treasure Island, FLStatPearls2024
     [Google Scholar]
  8. CarterE. BruinvelsG. TimminsK. PedlarC. MartinD. Menopausal symptoms, exercise practices, and advice received in active women: A multi-country survey of strava app users.Women Health2024641233110.1080/03630242.2023.2284730 37996389
     [Google Scholar]
  9. HuangK.E. Menopause perspectives and treatment of Asian women.Semin. Reprod. Med.201028539640310.1055/s‑0030‑1262899 20845238
     [Google Scholar]
  10. DalalP. AgarwalM. Postmenopausal syndrome.Indian J. Psychiatry2015576S222S23210.4103/0019‑5545.161483 26330639
     [Google Scholar]
  11. EcheverriaV. EcheverriaF. BarretoG.E. EcheverríaJ. MendozaC. Estrogenic plants: To prevent neurodegeneration and memory loss and other symptoms in women after menopause.Front. Pharmacol.20211264410310.3389/fphar.2021.644103
     [Google Scholar]
  12. LuJ. LiK. ZhengX. LiuR. ChenM. XianJ. TuS. XieL. Prevalence of menopausal symptoms and attitudes towards menopausal hormone therapy in women aged 40–60 years: A cross-sectional study.BMC Womens Health202323147210.1186/s12905‑023‑02621‑8 37667324
     [Google Scholar]
  13. RainaP.M. ParmarM. Bazedoxifene.Treasure Island, FLStatPearls Publishing2024
     [Google Scholar]
  14. ZhuX. LiewY. LiuZ.L. Chinese herbal medicine for menopausal symptoms.Cochrane Libr.201620165CD00902310.1002/14651858.CD009023.pub2 26976671
     [Google Scholar]
  15. MohapatraS. IqubalA. AnsariM.J. JanB. ZahiruddinS. MirzaM.A. AhmadS. IqbalZ. Benefits of black cohosh (Cimicifuga racemosa) for women health: An up-close and in-depth review.Pharmaceuticals202215327810.3390/ph15030278 35337076
     [Google Scholar]
  16. KargozarR. AziziH. SalariR. A review of effective herbal medicines in controlling menopausal symptoms.Electron. Physician20179115826583310.19082/5826 29403626
     [Google Scholar]
  17. NguyenT.M. DoT.T.T. TranT.N. KimJ.H. Exercise and quality of life in women with menopausal symptoms: A systematic review and meta-analysis of randomized controlled trials.Int. J. Environ. Res. Public Health20201719704910.3390/ijerph17197049 32993147
     [Google Scholar]
  18. TodorovaL. BonassiR. Guerrero CarreñoF.J. HirschbergA.L. YukselN. ReaC. ScrineL. KimJ.S. Prevalence and impact of vasomotor symptoms due to menopause among women in Brazil, Canada, Mexico, and Nordic Europe: A cross-sectional survey.Menopause202330121179118910.1097/GME.0000000000002265 37847872
     [Google Scholar]
  19. O’NeillS. EdenJ. The pathophysiology of menopausal symptoms.Obstetrics, Gynaecol. Reprod. Med.2017271030331010.1016/j.ogrm.2017.07.002
     [Google Scholar]
  20. BrintonR.D. YaoJ. YinF. MackW.J. CadenasE. Perimenopause as a neurological transition state.Nat. Rev. Endocrinol.201511739340510.1038/nrendo.2015.82 26007613
     [Google Scholar]
  21. GianniniA. CarettoM. GenazzaniA.R. SimonciniT. Neuroendocrine changes during menopausal transition.Endocrines20212440541610.3390/endocrines2040036
     [Google Scholar]
  22. DavisS.R. LambrinoudakiI. LumsdenM. MishraG.D. PalL. ReesM. SantoroN. SimonciniT. Menopause.Nat. Rev. Dis. Primers2015111500410.1038/nrdp.2015.4 27188659
     [Google Scholar]
  23. XiangD. LiuY. ZhouS. ZhouE. WangY. Protective effects of estrogen on cardiovascular disease mediated by oxidative stress.Oxid. Med. Cell. Longev.202120211552351610.1155/2021/5523516 34257804
     [Google Scholar]
  24. VerdeL. BarreaL. VetraniC. Frias-ToralE. ChapelaS.P. JayawardenaR. de AlteriisG. DocimoA. SavastanoS. ColaoA. MuscogiuriG. Chronotype and sleep quality in obesity: How do they change after menopause?Curr. Obes. Rep.202211425426210.1007/s13679‑022‑00479‑9 36053414
     [Google Scholar]
  25. JanickiS.C. SchupfN. Hormonal influences on cognition and risk for Alzheimer’s disease.Curr. Neurol. Neurosci. Rep.201010535936610.1007/s11910‑010‑0122‑6 20535591
     [Google Scholar]
  26. SarmentoA.C.A. CostaA.P.F. Vieira-BaptistaP. GiraldoP.C. EleutérioJ. GonçalvesA.K. Genitourinary syndrome of menopause: Epidemiology, physiopathology, clinical manifestation and diagnostic.Front Reprod. Health.2021377939810.3389/frph.2021.779398 36304000
     [Google Scholar]
  27. KundakovicM. RocksD. Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms.Front. Neuroendocrinol.20226610101010.1016/j.yfrne.2022.101010 35716803
     [Google Scholar]
  28. KerlikowskeK. CookA.J. BuistD.S.M. CummingsS.R. VachonC. VacekP. MigliorettiD.L. Breast cancer risk by breast density, menopause, and postmenopausal hormone therapy use.J. Clin. Oncol.201028243830383710.1200/JCO.2009.26.4770 20644098
     [Google Scholar]
  29. Tropicos: Elephantopus L2019Available from: http://www.tropicos.org/Name/40002032
  30. GBIF (Global Biodiversity Information Facility)Elephantopus scaber L.Available at: https://www.gbif.org/species/5395925 (Accessed July 14, 2025).
     [Google Scholar]
  31. MartinA.B. The vocabulary of orchids: An amateur perspective.2005Available from: (Accessed May 27, 2024).https://nossaorg.files.wordpress.com/2014/02/martin.pdf.
     [Google Scholar]
  32. GledhillD. The names of plants.Cambridge, EnglandCambridge University Press200810.1017/CBO9780511550898
     [Google Scholar]
  33. Flowers of india2023Available from:(Accessed May 28, 2024).https://www.flowersofindia.net/catalog/slides/Elephant%20Foot.html
  34. Encyclopedia of life (EOL): Elephantopus scaber.2023Available from: http://eol.org/pages/2895957/names/common_namesr
    [Google Scholar]
  35. JainD. DhamdarT.S. NisarahmedE.M. PrasadS. MishraA.D. MishraS. KumarS. Adhomukha (Elephantopus scaber L): A medicinal herb of India.Med. Aster.: India2024111010.5281/zenodo.10709847
     [Google Scholar]
  36. DeshpandeD.J. A hand book of medicinal herbs: A source book of herbal remedies, chemical constituents, biological activities and usage.Jodhpur, IndiaAgrobios2010
     [Google Scholar]
  37. Eflora - Digital Flora of TaiwanAvailable from: http://www.efloras.org/florataxon.aspx?flora_id=100&taxon_id=111427
  38. Kew Science - Plant of the World OnlineAvailable from: https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:202958-1
  39. WuT. CuiH. ChengB. FangS. XuJ. GuQ. Chemical constituents from the roots of Elephantopus scaber L.Biochem. Syst. Ecol.201454656710.1016/j.bse.2013.12.012
     [Google Scholar]
  40. HoW.Y. KyH. YeapS.K. RahimR.A. OmarA.R. HoC.L. AlitheenN.B. Traditional practice, bioactivities and commercialization potential of Elephantopus scaber Linn.J. Med. Plants Res.200931312121221
     [Google Scholar]
  41. WangJ. LiP. LiB. GuoZ. KennellyE.J. LongC. Bioactivities of compounds from Elephantopus scaber, an ethnomedicinal plant from southwest China.Evid. Based Complement. Alternat. Med.20142014156959410.1155/2014/569594 24963325
     [Google Scholar]
  42. SuM. WuX. ChungH.Y. LiY. YeW. Antiproliferative activities of five Chinese medicinal herbs and active compounds in Elephantopus scaber.Nat. Prod. Commun.2009481025103010.1177/1934578X0900400802 19768977
     [Google Scholar]
  43. AhmadA. AlkarkhiA.F.M. HenaS. KhimL.H. Extraction, separation and identification of chemical ingredients of Elephantopus scaber L. using factorial design of experiment.Int. J. Chem.2009113610.5539/ijc.v1n1p36
     [Google Scholar]
  44. MendhulkarV.D. KharatS.N. HPLC assay, phytochemical, FTIR characterization and studies on antioxidant activity of Elephantopus scaber (Linn) using six different soxhlet leaf extract.Pharma Chem.20179231828
     [Google Scholar]
  45. Al-ShaheenM.R. Al ShaheenM.A. AboodM.F. Identify bioactive compounds by Gc-Ms from the highest antimicrobial extract from roots and leaves of Elephantopus scaber.Inter J. Pharmaceut. Qua Assur20191004619624
     [Google Scholar]
  46. Kumar ShuklaP. MisraA. KumarB. NiranjanA. SrivastavaS. Simultaneous RP-HPLC quantification of four phenolics in Elephantopus scaber L. and their in vitro pharmacological validation.Indian J. Pharma Edu Res.2020542ss368s37310.5530/ijper.54.2s.95
     [Google Scholar]
  47. Antro JennieX. Jenila BejadsX. Srinivasa KumarK.P. SrinivasK. RajeshM. Phytochemical studies and GC-MS analysis of the plant Elephantopus scaber.J. Glob. Trends Pharm. Sci.20134110531057
     [Google Scholar]
  48. WangaL. JianS. NanP. ZhongY. Chemical composition of the essential oil of Elephantopus scaber from Southern China.Z. Naturforsch. C J. Biosci.2004595-632732910.1515/znc‑2004‑5‑606 18998395
     [Google Scholar]
  49. GeethaB.S. NairM.S. LathaP.G. RemaniP. Sesquiterpene lactones isolated from Elephantopus scaber L. inhibits human lymphocyte proliferation and the growth of tumour cell lines and induces apoptosis in vitro.J. Biomed. Biotechnol.2012201211810.1155/2012/721285 22500104
     [Google Scholar]
  50. BitwellC. IndraS.S. LukeC. KakomaM.K. A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants.Sci. Am.202319e0158510.1016/j.sciaf.2023.e01585
     [Google Scholar]
  51. HossainM.B. LebelleJ. BirsanR. RaiD.K. Enrichment and assessment of the contributions of the major polyphenols to the total antioxidant activity of onion extracts: A fractionation by flash chromatography approach.Antioxidants201871217510.3390/antiox7120175 30486352
     [Google Scholar]
  52. SarmaM.D. High speed counter-current chromatography: A modern tool for selective and greener extraction of bioactive phytochemicals from rhubarb.Int. J. Pharm. Sci. Rev. Res.202277117217810.47583/ijpsrr.2022.v77i01.028
     [Google Scholar]
  53. PitchaiD. RoyA. IgnatiusC. In vitro evaluation of anticancer potentials of lupeol isolated from Elephantopus scaber L. on MCF-7 cell line.J. Adv. Pharm. Technol. Res.20145417918410.4103/2231‑4040.143037 25364696
     [Google Scholar]
  54. KharatS.N. SinghR. MendhulkarV.D. Quantitative analysis for “Diosgenin” content in Elephantopus scaber (Linn.) by HPTLC using successive solvent extraction method.Pharm. Lett.201575236244
     [Google Scholar]
  55. KrishnaV. MankaniK.L. ManjunathaB.K. VidyaS.M. ManoharaY.N. SinghS.J. Wound healing activity of the leaf extracts and deoxyelephantopin isolated from Elephantopus scaber Linn.Indian J. Pharmacol.200537423810.4103/0253‑7613.16570
     [Google Scholar]
  56. DaisyP. JasmineR. IgnacimuthuS. MuruganE. A novel Steroid from Elephantopus scaber L. an Ethnomedicinal plant with antidiabetic activity.Phytomedicine2009162-325225710.1016/j.phymed.2008.06.001 18693100
     [Google Scholar]
  57. JamalR.K. JoseV. Determination of phytochemicals by GC-MS in methanol extract of Elephantopus scaber L.J. Pharmacogn. Phytochem.201766807813
     [Google Scholar]
  58. PoliA. NicolauM. Oliveira SimõesC.M. Ribeiro-do-Valle NicolauR.M. ZaninM. Preliminary pharmacologic evaluation of crude whole plant extracts of Elephantopus scaber. Part I: In vivo studies.J. Ethnopharmacol.1992371717610.1016/0378‑8741(92)90005‑C 1453704
     [Google Scholar]
  59. LinC.C. TsaiC.C. YenM.H. The evaluation of hepatoprotective effects of Taiwan folk medicine ‘Teng-Khia-U’.J. Ethnopharmacol.199545211312310.1016/0378‑8741(94)01198‑9 7776660
     [Google Scholar]
  60. AndyS.N. PandyV. AliasZ. KadirH.A. Deoxyelephantopin ameliorates lipopolysaccharides (LPS)-induced memory impairments in rats: Evidence for its anti-neuroinflammatory properties.Life Sci.2018206456010.1016/j.lfs.2018.05.035 29792878
     [Google Scholar]
  61. DaisyP. PriyaC.E. Hypolipidemic and renal functionality potentials of the hexane extract fractions of Elephantopus scaber linn.Int. J. Biomed. Sci.20106324124510.59566/IJBS.2010.6241 23675198
     [Google Scholar]
  62. LinzaA. WillsP.J. AnsilP.N. PrabhaS.P. NithaA. LathaB. SheebaK.O. LathaM.S. Dose-response effects of Elephantopus scaber methanolic extract on N-nitrosodiethylamine-induced hepatotoxicity in rats.Chin. J. Nat. Med.201311436237010.1016/S1875‑5364(13)60053‑9 23845544
     [Google Scholar]
  63. HuangC.C. LoC.P. ChiuC.Y. ShyurL.F. Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice.Br. J. Pharmacol.2010159485687110.1111/j.1476‑5381.2009.00581.x 20105176
     [Google Scholar]
  64. VermaS.S. RaiV. AwastheeN. DhasmanaA. RajalaksmiD.S. NairM.S. GuptaS.C. Isodeoxyelephantopin, a sesquiterpene lactone induces ROS generation, suppresses NF-κB activation, modulates LncRNA expression and exhibit activities against breast cancer.Sci. Rep.2019911798010.1038/s41598‑019‑52971‑3 31784542
     [Google Scholar]
  65. HiradeveS. RangariV. Immunomodulatory study of different solvent extract of Elephantopus scaber Linn.Drug Res.201767423924310.1055/s‑0042‑124357 28158892
     [Google Scholar]
  66. KabeerF.A. PrathapanR. Phytopharmacological profile of Elephantopus scaber.Pharmacol.20145827228510.5567/pharmacologia.2014.272.285
     [Google Scholar]
  67. SagarR. SahooH.B. Evaluation of antiasthmatic activity of ethanolic extract of Elephantopus scaber L. leaves.Indian J. Pharmacol.201244339840110.4103/0253‑7613.96347 22701255
     [Google Scholar]
  68. LiuK. ZhangX. XieL. DengM. ChenH. SongJ. LongJ. LiX. LuoJ. Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy.Pharmacol. Res.202116410537310.1016/j.phrs.2020.105373 33316380
     [Google Scholar]
  69. ChanC.K. TanL.T.H. AndyS.N. KamarudinM.N.A. GohB.H. KadirH.A. Anti-neuroinflammatory activity of Elephantopus scaber L. via activation of Nrf2/HO-1 signaling and inhibition of p38 MAPK pathway in LPS-induced microglia BV-2 cells.Front. Pharmacol.2017839710.3389/fphar.2017.00397 28680404
     [Google Scholar]
  70. TamokouJ.D. KueteV. Toxic plants used in african traditional medicine.Toxicological Survey of African Medicinal Plants.Elsevier201413518010.1016/B978‑0‑12‑800018‑2.00007‑8
     [Google Scholar]
  71. Boukandou MounangaM. MewonoL. Aboughe AngoneS. Toxicity studies of medicinal plants used in sub-Saharan Africa.J. Ethnopharmacol.201517461862710.1016/j.jep.2015.06.005 26087230
     [Google Scholar]
  72. HoW.Y. YeapS.K. HoC.L. Abdul RahimR. AlitheenN.B. Hepatoprotective activity of Elephantopus scaber on alcohol‐induced liver damage in mice.Evid. Based Complement. Alternat. Med.201220121417953 22973401
     [Google Scholar]
  73. KabeerF.A. SreedeviG.B. NairM.S. RajalekshmiD.S. GopalakrishnanL.P. PrathapanR. Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells.Chin. Med.2014911410.1186/1749‑8546‑9‑14 24742378
     [Google Scholar]
  74. YulianiY. KhaleylaF. Anggorowati RahayuD. Potential of bioactive compound from Elephantopus scaber Linn. leaf as anti-cancer through in-silico test.J. Med. Chem. Sci.2023681773178210.26655/JMCHEMSCI.2023.8.6
     [Google Scholar]
  75. GuoY. LiM. ChenP. WuQ. GaoC. LuY. ZhangL. YuanD. FuH. A pair of new elemanolide sesquiterpene lactones from Elephantopus scaber L.Magn. Reson. Chem.201755767768110.1002/mrc.4567 27976412
     [Google Scholar]
  76. NeamsuvanO. RuangritT. A survey of herbal weeds that are used to treat gastrointestinal disorders from southern Thailand: Krabi and Songkhla provinces.J. Ethnopharmacol.2017196849310.1016/j.jep.2016.11.033 27956357
     [Google Scholar]
  77. GengH.W. ZhangX.L. WangG.C. YangX.X. WuX. WangY.F. YeW-C. LiY-L. Antiviral dicaffeoyl derivatives from Elephantopus scaber.J. Asian Nat. Prod. Res.201113766566910.1080/10286020.2011.584310
     [Google Scholar]
  78. RaghavanG.V. Comprehensive Medicinal Plants (Volume 3)Houston, TXStudium Press2011
     [Google Scholar]
  79. GhaniA. Medicinal Plants of Bangladesh: Chemical Constituents and Uses.2nd edBangladeshAsiatic Society of Bangladesh2003142145
     [Google Scholar]
  80. Useful tropical plants2024Available from: https://tropical.theferns.info/
  81. BhutyaR.K. Ayurvedic medicinal plants of india.IndiaScientific Publishers20111
     [Google Scholar]
  82. AvaniK. NeetaS. A study of the antimicrobial activity of Elephantopus scaber.Indian J. Pharmacol.200537212612810.4103/0253‑7613.15115
     [Google Scholar]
  83. JasmineR. DaisyP. SelvakumarB.N. Evaluating the antibacterial activity of Elephantopus scaber extracts on clinical isolates of β-lactamase producing methicillin resistant Staphylococcus aureus from UTI Patients.Int. J. Pharmacol.20073216516910.3923/ijp.2007.165.169
     [Google Scholar]
  84. BhaijiA. BhattamisraS.K. MandalP.K. SagarR. SahooH.B. A new weapon for memory power: Elephantopus scaber (Linn.).Int. J. Nutr. Pharmacol. Neurol. Dis.201441646810.4103/2231‑0738.124616
     [Google Scholar]
  85. SaivishalD. SwamyB.M.V. SwamyK.M.V. Cardioprotective effect of Elepahnopus scaber Linn. on the isolated rat heart in ischemia-reperfusion induced myocardial damage.Res. J. Pharm. Biol. Chem. Sci.201233778
     [Google Scholar]
  86. HoW.Y. LiewS.S. YeapS.K. AlitheenN.B. Synergistic cytotoxicity between Elephantopus scaber and tamoxifen on MCF-7-derived multicellular tumor spheroid.Evid. Based Complement. Alternat. Med.20212021111510.1155/2021/6355236 34712346
     [Google Scholar]
  87. HoW.Y. YeapS.K. HoC.L. RahaA.R. SurainiA.A. AlitheenN.B. Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis.J. Med. Plants Res.201152457415749
     [Google Scholar]
  88. SulistyaniN. Nurkhasanah, The cytotoxic effect of Elephantopus scaber Linn extract against breast cancer (T47D) cells.IOP Conf. Series Mater. Sci. Eng.2017259101200610.1088/1757‑899X/259/1/012006
     [Google Scholar]
  89. TsaiC.C. LinC.C. Anti-inflammatory effects of Taiwan folk medicine ‘Teng-Khia-U’ on carrageenan- and adjuvant-induced paw edema in rats.J. Ethnopharmacol.1998641858910.1016/S0378‑8741(98)00108‑1 10075126
     [Google Scholar]
  90. GongR.H. ChenJ.W. ShenL.S. LinY.S. YuH. ChenS. ChenG.Q. Assessing the therapeutic potential of Elephantopus scaber extract in hepatocellular carcinoma by inhibiting the PI3K/Akt pathway.J. Funct. Foods202411310600910.1016/j.jff.2024.106009
     [Google Scholar]
  91. HanJ. Traditional Chinese medicine and the search for new antineoplastic drugs.J. Ethnopharmacol.198824111710.1016/0378‑8741(88)90135‑3 3059066
     [Google Scholar]
  92. LeeW. Treatment of acne by topical herbal extract solution.US Patent 20050084473A12005
  93. HozumiT. MatsumotoT. OoyamaH. MambaT. ShirakiK. HattoriM. KurokawaM. KadotaS. Antiviral agent containing crude drug.US Patent 5411733A1995
  94. PortellaC.F.S. SilvaI.D.A. SimõesR.S. GhelmanR. BaracatE.C. JúniorJ.M.S. SorpresoI.C.E. An overview of systematic reviews of medicinal plants and herbal formulations for the treatment of climacteric symptoms.J. Herb. Med.20244510086310.1016/j.hermed.2024.100863
     [Google Scholar]
  95. ParkE.J. BaekS.E. KimM. KimA.R. ParkH.J. KwonO. LeeJ.H. YooJ.E. Effects of herbal medicine (Danggwijagyaksan) for treating climacteric syndrome with a blood-deficiency-dominant pattern: A randomized, double-blind, placebo-controlled pilot trial.Integr. Med. Res.202110310071510.1016/j.imr.2021.100715 33665100
     [Google Scholar]
  96. MinenkoI.A. BerihanovaR.R. ShakhmatovaS.A. Effect of the mixed herbal medicines extracts on menopausal symptoms: A randomized clinical trial study.Elect J. Gen. Med.2019163em13710.29333/ejgm/109435
     [Google Scholar]
  97. FrancoO.H. ChowdhuryR. TroupJ. VoortmanT. KunutsorS. KavousiM. Oliver-WilliamsC. MukaT. Use of plant-based therapies and menopausal symptoms: A systematic review and meta-analysis.JAMA2016315232554256310.1001/jama.2016.8012 27327802
     [Google Scholar]
  98. HuntleyA. Drug-herb interactions with herbal medicines for menopause.J. Br. Menopause Soc.200410416216510.1258/1362180042721067 15667753
     [Google Scholar]
/content/journals/npj/10.2174/0122103155352527250407055540
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Harnessing the Unexplored Therapeutic Essence of Elephantopus scaber L. for Menopausal Symptom Management
Natural Products Journal, The 16, E22103155352527 (2026); https://doi.org/10.2174/0122103155352527250407055540
/content/journals/npj/10.2174/0122103155352527250407055540
/content/journals/npj/10.2174/0122103155352527250407055540
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  • Article Type:     Review Article
Keyword(s): Elephantopus scaber; menopausal consequences; pharmacological properties; phytochemicals; phytoestrogens; traditional medicines

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