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2000
Volume 15, Issue 3
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163
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Abstract

Background

Fungi found in unique and competitive environments are abundant in bioactive compounds.

Objective

The objective of this study is to isolate and identify secondary metabolites from fungi of unique ecological niches and evaluate their cytotoxicity.

Methods

The compounds were isolated and purified using silica gel column chromatography, Sephadex LH-20 gel chromatography, and semi-preparative high-performance liquid chromatography (HPLC). The structures of the isolated compounds were determined using NMR and MS. The cytotoxic activities of these compounds were tested by the MTS assay.

Results

Three diphenyl ethers, dechlorodihydromaldoxin (), violaceol-I () and violaceol-II (), one quinolinone compound, 2-(2-heptenyl)-3-methyl-4(1)-quinolinone (), and one -pyrone nafuredin () were isolated from the fermented extracts of S161. Compound showed modest cytotoxicity against two human tumor cell lines A549 and MCF-7, with IC values of 87.12 and 51.07 μM, respectively.

Conclusion

Five compounds were isolated from the fungus S161. Compound showed moderate cytotoxicity. This study provided a basis for the development of antitumor drugs.

© 2025 The Author(s). Published by Bentham Science Publisher.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode.
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Cytotoxic Secondary Metabolites from the Ascomycetous Fungus Pseudogymnoascus roseus
Natural Products Journal, The 15, E060524229697 (2025); https://doi.org/10.2174/0122103155302795240430043401
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  • Article Type:     Research Article
Keyword(s): biological activities; diphenyl ethers; fungi; quinolinone; structure elucidation; α-pyrone

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