Skip to content
2000
Volume 5, Issue 1
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
file format pdf download PDF
file format text download EPUB
side by side viewer icon HTML

Abstract

Introduction

Ankylosing spondylitis (AS), also known as rheumatic pelvic spondylitis, is considered the primary condition in a group of chronic inflammatory rheumatic diseases collectively referred to as spondyloarthropathies.

Objectives

This study aimed to explore the association between ABCB1 C3435T polymorphism and the predisposition to ankylosing spondylitis (AS) in the Algerian population. The frequency of this polymorphism was compared between the group of AS and healthy subjects.

Methods

A case-control study involving 81 AS patients and 98 controls was conducted. DNA genotyping was done using predesigned probe-based allelic discrimination TaqMan® assays. Allele and genotype frequencies were compared between cases and controls, and statistical analyses were executed using SAS software (version 9.1, SAS Institute Inc., Cary, NC).

Results

No statistically significant differences were observed in the frequencies of ABCB1 genotypes and alleles between AS cases and the control group. In contrast, the recessive model (CC+CT/TT) (OR = 8.99 [11.97-40.99], = 0.004) was significantly associated with the mixed form of the disease, while the heterozygous 3435CT genotype provided protection against the axial form. Moreover, a positive association was also found between the ABCB1 C3435T polymorphism and BMI (OR: 5.19 [1.41-19.9], = 0.01).

Conclusion

This is the first study to explore the association of ABCB1 polymorphisms with susceptibility to ankylosing spondylitis in an Algerian population. It was determined that the ABCB1 C3435T SNP does not influence the risk of AS but rather affects the disease phenotype and body mass index (BMI).

© 2024 The Author(s).
© 2024 The Author(s). Published by Bentham Science Publishers. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
Loading

Article metrics loading...

/content/journals/nemj/10.2174/0102506882366282250314044806
2024-01-01
2025-10-31

  • From This Site

    /content/journals/nemj/10.2174/0102506882366282250314044806
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/nemj/5/1/NEMJ-5-E02506882366282.html?itemId=/content/journals/nemj/10.2174/0102506882366282250314044806&mimeType=html&fmt=ahah

References

  1. Rychlik-SychM. BarańskaM. DudarewiczM. SkrętkowiczJ. ŻebrowskaA. WoźniackaA. OwczarekJ. Orszulak-MichalakD. WaszczykowskaE. Haplotypes of ABCB1 1236C >T (rs1128503), 2677G >T/A (rs2032582), and 3435C >T (rs1045642) in patients with bullous pemphigoid.Arch. Dermatol. Res.2018310651552210.1007/s00403‑018‑1842‑829948283
     [Google Scholar]
  2. RobinsonW.P. van der LindenS.M. KhanM.A. RentschH.U. CatsA. RussellA. ThomsonG. HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients.Arthrit. Rheum.19893291135114110.1002/anr.17803209122789045
     [Google Scholar]
  3. BoughraraW. AberkaneM. FodilM. BenzaouiA. DorghamS. ZemaniF. DahmaniC. Petit TeixeiraE. BoudjemaA. Impact of MTHFR rs1801133, MTHFR rs1801131 and ABCB1 rs1045642 polymorphisms with increased susceptibility of rheumatoid arthritis in the West Algerian population: A case-control study.Acta Reumatol. Port.201540436337126922200
     [Google Scholar]
  4. BarańskaM. Rychlik-SychM. SkrętkowiczJ. DudarewiczM. Dziankowska-BartkowiakB. OwczarekJ. WaszczykowskaE. Genotype and haplotype analysis of ABCB1 at 1236, 2677 and 3435 among systemic sclerosis patients.Autoimmunity201750527728210.1080/08916934.2017.132942128534442
     [Google Scholar]
  5. PawlikA. WrzesniewskaJ. Fiedorowicz-FabrycyI. Gawronska-SzklarzB. The MDR1 3435 polymorphism in patients with rheumatoid arthritis.Int. J. Clin. Pharmacol. Ther.200442949650310.5414/CPP4249615487808
     [Google Scholar]
  6. De AngelisR. SalaffiF. GrassiW. Prevalence of spondyloarthropathies in an Italian population sample: A regional community‐based study.Scand. J. Rheumatol.2007361142110.1080/0300974060090424317454930
     [Google Scholar]
  7. IchiharaS. YamadaY. KatoK. HibinoT. YokoiK. MatsuoH. KojimaT. WatanabeS. MetokiN. YoshidaH. SatohK. AoyagiY. YasunagaA. ParkH. TanakaM. NozawaY. Association of a polymorphism of ABCB1 with obesity in Japanese individuals.Genomics200891651251610.1016/j.ygeno.2008.03.00418442890
     [Google Scholar]
  8. García-CarrascoM. Mendoza-PintoC. Macias DíazS. Vera-RecabarrenM. Vázquez de LaraL. Méndez MartínezS. Soto-SantillánP. González-RamírezR. Ruiz-ArguellesA. P-glycoprotein in autoimmune rheumatic diseases.Autoimmun. Rev.201514759460010.1016/j.autrev.2015.02.00625712147
     [Google Scholar]
  9. DahmaniC.A. BenzaouiA. AmrounH. MecabihF. SedikiF.Z. Zemani-FodilF. FodilM. BoughraraW. MechetiB. AttalN. MehtarN. Petit-TeixeiraE. BoudjemaA. Association of the HLA‐B27 antigen and the CTLA4 gene CT60/rs3087243 polymorphism with ankylosing spondylitis in Algerian population: A case–control study.Int. J. Immunogenet.201845310911710.1111/iji.1236929675891
     [Google Scholar]
  10. DahmaniC.A. BenzaouiA. AmrounH. Zemani-FodilF. Petit-TeixeiraE. BoudjemaA. Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population.Int. J. Immunogenet.201946643744310.1111/iji.1245431433132
     [Google Scholar]
  11. AsmaaA. AhmedB. HabibaA. AmiraD. ChahinezA. ElisabethP.T. AbdallahB. Characterization of ERAP1 rs30187 and rs10050860 polymorphisms and their association with ankylosing spondylitis in the algerian population association of ERAP1 in algeria.Egypt. Acad. J. Biol. Sci. C Physiol. Mol. Biol.2022142109120
     [Google Scholar]
  12. AmorB. DougadosM. MijiyawaM. Criteria of the classification of spondylarthropathies.Rev. Rhum. Mal. Osteoartic.199057285892181618
     [Google Scholar]
  13. AbbaA. NiasseM. DiabyL.M. AliH. Ankylosing spondylitis in Senegal: Epidemiological, diagnostic, therapeutic and progressive aspects at the Aristide LeDantec University Hospital Center in Dakar.Pan Afr. Med. J.2021401510.11604/pamj.2021.40.15.2952534733383
     [Google Scholar]
  14. CutoloM. VillaggioB. SerioloB. MontagnaP. CapellinoS. StraubR.H. SulliA. Synovial fluid estrogens in rheumatoid arthritis.Autoimmun. Rev.20043319319810.1016/j.autrev.2003.08.00315110231
     [Google Scholar]
  15. CascorbiI. GerloffT. JohneA. MeiselC. HoffmeyerS. SchwabM. SchaeffelerE. EichelbaumM. BrinkmannU. RootsI. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.Clin. Pharmacol. Ther.200169316917410.1067/mcp.2001.11416411240981
     [Google Scholar]
  16. JamroziakK. BalcerczakE. MłynarskiW. MirowskiM. RobakT. Distribution of allelic variants of functional C3435T polymorphism of drug transporter MDR1 gene in a sample of Polish population.Pol. J. Pharmacol.200254549550012593536
     [Google Scholar]
  17. NurmatovaS. KapralovaY. AbdurakhimovA. TurdikulovaS. DalimovaD. Determination of the frequency of ABCB1 gene polymorphisms (C1236T, C3435T) in the population of the Tashkent region of Uzbekistan.Biotechnol. Biochem. Res.20221011610.30918/BBR.101.21.023
     [Google Scholar]
  18. Menopause and Chronic Pain.2023Available from: https://www.healthcentral.com/condition/menopause/menopause-chronic-pain (Accessed on: 19 Sep 2023).
/content/journals/nemj/10.2174/0102506882366282250314044806
Loading
Association of the ABCB1 C3435T Polymorphism with the Mixed Form of Ankylosing Spondylitis in the Algerian Population: A Case-control Study
NEW Emirates Medical J 5, e02506882366282 (2024); https://doi.org/10.2174/0102506882366282250314044806
/content/journals/nemj/10.2174/0102506882366282250314044806
/content/journals/nemj/10.2174/0102506882366282250314044806
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): ABCB1; Algerian population; Ankylosing spondylitis; Association; Axial form; C3435T

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test