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2000
Volume 5, Issue 1
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Introduction

Iron-Deficiency Anemia (IDA) is a global burden affecting more than a billion individuals. It is most prevalent due to nutritional deficiencies. Researchers have linked Selenium (Se) to anemia and erythropoiesis.

Aim

This interventional-study was designed to investigate the plasma Se concentration and its supplementation impact in IDA patients receiving standard treatment.

Methodology

In the present study, a total of 215 IDA patients were enrolled from different departments of AIIMS, New Delhi, after getting ethical authorization from the Institutional-Ethical Committee. Iron supplements were administered to patients with only IDA, while a combination of iron and selenium supplements was given to patients with selenium-deficient IDA for 90 days. Parameters such as hemoglobin, hematocrit, RBC count, serum ferritin, transferrin, TIBC, and plasma Se levels were measured on the baseline and the 90th day.

Results

All blood parameters were significantly below the normal reference range on the 0th day. Se levels were found to be higher in the study population {57% (122/215) in IDA}. Further, in low plasma Se IDA patients 26% (55/215), treatment with iron and Se supplements for 90 days significantly improved all blood parameters and led to a subjective improvement of the patient’s well-being.

Conclusion

Selenium levels are variable in patients with IDA, and no correlation can be drawn for the benefit of selenium in the IDA. Further, the high prevalence of nutrition-related disorders such as IDA highlights the need to avoid blind Se supplementation along with iron. These combination in the form of nutritional supplements having Se are rampantly available and sold over the counter. So, supplements with Se shouldn’t be generalized to IDA patients..

Clinical Trial Registration No.

CTRI/2023/04/051405

© 2024 The Author(s).
© 2024 The Author(s). Published by Bentham Science Publishers. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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Prevalence and Impact of Selenium in Iron-deficiency Anemia: Insights from a Clinical Trial on Anemia Correction and Symptom Improvement
NEW Emirates Medical J 5, E02506882362987 (2024); https://doi.org/10.2174/0102506882362987250314044238
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  • Article Type:     Research Article
Keyword(s): Anemia; Clinical trial; Essential elements; Hematological parameter; Iron deficiency; Selenium

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