Improving Asymmetric Organocatalysts via Supramolecular Interactions

Since the rediscovery of proline as a catalyst in aldol reaction in 2000 by List, Barbas and Lerner and, soon after, the development of imonium catalysis by D. W. C. MacMillan, the emergence of Organocatalysis as an important instrument in Organic Synthesis is outstanding. Nowadays, one of the most important goals for chemist is the quest for new and more efficient catalysts. One emerging tool for improving existent organocatalysts consists in using additives which interact with the catalysts via supramolecular interactions such as hydrogen bonding. These interactions provide better catalysts in terms of activity and selectivity. The present review aims to cover and discuss the current evolution of this fast growing field.