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2000
Volume 21, Issue 10
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

Background

Owing to their extensive utilization as pesticides, heterocycles assume a fundamental role in the management of vector-borne diseases. Despite the presence of numerous heterocyclic compounds in commercial insecticides and larvicides, resistance to pesticides still demands novel strategies to current pest control methods. Considering these facts, this review aims to survey the synthesis and SAR of heterocyclic molecules with larvicidal activity against Linn.

Methods

Comprehensive searches across the major databases were conducted to identify heterocyclic compounds exhibiting larvicidal efficacy against with the goal to unveil the main characteristics that are essential for exhibiting larvicidal activity.

Results

Active compounds display LC values varying from 0.36 to 2907 µM. Fifteen heterocyclic compounds displayed larvicidal activities below 20 µM. Five-membered ring molecules containing nitrogen and oxygen have displayed larvicidal activity according to the position of heteroatoms in the ring. Molecules bearing 1,2,4-oxadiazole and 1,2-oxazole moieties have been shown to be more active than 1,3,4-oxadiazole derivatives. Compounds possessing the indole scaffold have proven to be more potent than isatin and pyrimidine derivatives. Structural characteristics other than a heterocyclic moiety, such as the presence of halogens and less ionized and polar molecules, may also play a role in determining the final larvicidal activity.

Conclusion

The rationale behind this review is to stimulate the discovery of innovative heterocyclic larvicides. Thus, it is important to continue synthesizing new scaffolds to comprehensively elucidate the structure-activity relationship for each heterocyclic moiety outlined in this investigation.

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/content/journals/mc/10.2174/0115734064345432241120101422
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Synthetic Strategies for the Development of Novel Heterocycles as Larvicides Targeting Aedes aegypti Linn.
Med. Chem. 21, 1033 (2025); https://doi.org/10.2174/0115734064345432241120101422
/content/journals/mc/10.2174/0115734064345432241120101422
/content/journals/mc/10.2174/0115734064345432241120101422
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  • Article Type:     Review Article
Keyword(s): activity; arboviruses; heterocyclics; indoles; isoxazoles; novel larvicides; oxadiazoles; pyrazolines; Pyrimidines; synthesis; Zika

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