Letters in Organic Chemistry - Volume 6, Issue 1, 2009

A green catalytic method for C-C and C-N bond forming via Michael addition of aromatic amines and indoles to electron-deficient olefins using Zirconium tetrakis(dodecylsulfate) in water under mild conditions with high yields and selectivity has been developed. The reusability of the catalyst has been successfully examined without any noticeable loss of its catalytic activity.

Regioselectivity is investigated in multi-component reaction of amino triazole, carbonyl compounds and α- cyano esters derivative and exclusive synthesis of triazolopyrimidines is developed in aqueous medium in excellent yields in shorter period using microwaves or ultrasonic waves. Path and mechanism of the reaction has also been discussed. The operational simplicity, environmental friendly conditions, regioselective formation of target product, high yield in significantly very short reaction time, are major benefits.