Letters in Organic Chemistry - Volume 2, Issue 7, 2005

The substituted 3,4-dihydropyrimidin-2(1H)-ones and their thione analogues have been prepared Via Biginelli condensation using aldehyde, 1,3-dicarbonyl compound and urea or thiourea under the catalyst of sulphamic acid (H2NSO3H). The method is simple, cost-effective, and gives good yields in a shorter reaction time.

Using 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopyranose 1 as a model thioglycosyl donor, four different synthetic routes were explored to produce several types of original monoterpenyl thioglycosides.