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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Squaramide-Catalyzed Enantioselective Michael Addition of Pyrazol-3-ones to ortho-Quinone Methides
- Source: Letters in Organic Chemistry, Volume 17, Issue 11, Nov 2020, p. 837 - 844
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- 01 Nov 2020
Abstract
A bifunctional squaramide catalyzed the enantioselective Michael addition of pyrazol-3- ones to ortho-quinone methides, generated in situ from 2-(1-tosylalkyl)phenols is presented. The corresponding chiral pyrazolones are obtained with good to excellent yields (27-98%) and enantiomeric excess (14-99% ee).
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