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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Scope of Chiral Cyclopropanations of Various α-functionalized Diazoketone Derivatives with Styrene Catalyzed by p-Nitro Ru(II)-diphenyl- Pheox Complex
- Source: Letters in Organic Chemistry, Volume 20, Issue 11, Nov 2023, p. 1055 - 1061
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- 01 Nov 2023
Abstract
Following the success of the first intermolecular cyclopropanations of diazo acetoxy acetone with olefins using a novel p-nitro-Ru(II)-diphenyl-Pheox catalyst, other α-functionalized diazoketones have synthesized using the same reaction conditions. Consequently, chiral cyclopropyl products were formed with excellent yield (up to 87% yield), high diastereoselectivity (up to 99:1), and high enantioselectivity (up to 90% ee).
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