β-CD/Lewis Acid Dual Catalytic System for Efficient Synthesis of Pyranopyrazoles in Aqueous Environment

A series of pyranopyrazoles were synthesized via a one-pot four-component approach. The reaction was catalyzed by a β-CD/Yb(OTf)3 dual catalytic system. The protocol demonstrated offers several advantages such as short reaction times, excellent yields, good functional group tolerance, ambient and environmentally benign conditions, scalability and simple purification. Such dual catalytic systems are an attractive alternative to regular catalysts and can be further explored for a diverse set of reactions.