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This research paper presents a green, safe and easy synthesis of trans-chalcones under ultrasound irradiation in the presence of anionic resins. Several trans-Chalcones have been obtained following an environmentally friendly methodology using Amberlyte IRA-410 and Amberlyte IRA-400 resins as heterogeneous and efficient catalysts. The products of the condensation reaction were generally synthesized in good yields and the analysis confirmed their structures well.