Synthesis and Biological Evaluation of 6-Substituted Mangiferin Derivatives as Antioxidant and Anti-cancer Agents

Esterified and alkyl amine derivatives of mangiferin were synthesized and evaluated for in vitro antioxidant and anticancer activities. The chemical structures of the derivatives were confirmed using elemental analysis and spectral data. The antioxidant activity was assessed using a 2,2-diphenyl-1-picrylhydrazy (DPHH) assay, and some derivatives displayed antioxidant activity better than mangiferin and standard drug ascorbic acid. Among the synthesized derivatives, few exhibited more enhanced anticancer activity against human breast (MDA-MB-231) cancer cell lines than the parent mangiferin.