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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Friedel-Crafts Benzylation of Unprotected Anilines with Indole-3- carbinols to Access Trifluoro-methyl(indolyl)phenylmethanes
- Source: Letters in Organic Chemistry, Volume 19, Issue 5, May 2022, p. 353 - 361
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- 01 May 2022
Abstract
An unprecedented protocol for the efficient and highly chemoselective alkylation of unprotected anilines with deactivated CF3-indole-3-carbinols promoted by In(OTf)3 has been developed. A series of diversified trifluoromethylated (indolyl)phenylmethanes were produced featuring the C-alkylation in moderate to high chemical yields and with high regioselectivities.
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